The invention discloses a cleaning machine for human wastes. The cleaning machine comprises a fully automatic processor which is provided with a dirt discharge barrel, a negative pressure device, a hot water device, a hot air device, a packing device, a positive pressure device and a control device, adaptive underwear which is matched with the fully automatic processor, is provided with a waste collecting region, a defecation discharge outlet, a hot water output tube and a hot air output tube and is made of a flexible fabric, and a corresponding pipeline which connects the fully automatic processor with the adaptive underwear. Compared with the conventional automatic defecation processing system, the cleaning machine for the human wastes has the advantages that: 1, nursing personnel do not need to contact the defecation, so that the working environment is improve greatly when the nursing personnel clean the dirt discharge barrel, and the development of nursing practice is facilitated; and 2, the adaptive underwear is taken as a toilet stool and is flexible and comfortable, so that a user can wear the adaptive underwear for a long time, put on or off the toilet stool without the help of the nursing personnel, and start the cleaning machine for the human wastes at any time to defecate, and the cleaning machine for the human wastes is convenient to use.