The invention discloses a traditional Chinese medicine preparation for preventing and treating coronary artery injury of a kawasaki disease. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 9 parts of root of kudzu vine, 6 parts of salviae miltiorrhizae and 6 parts of ligusticum wallichii. According to the pharmacological action of the primary chemical components of root of kudzu vine, salviae miltiorrhizae and ligusticum wallichii, the traditional Chinese medicine preparation is proved to have the functions of increasing coronary blood-flow volume, improving blood oxygen supply of myocardium, reducing the oxygen consumption of myocardium, improving microcirculation, reducing the surface activity of blood platelets, inhibiting platelet aggregation and preventing thrombogenesis. In traditional Chinese medicine, the root of kudzu vine is a medicine for relieving exterior disorder, and salviae miltiorrhizae and ligusticum wallichii are medicines for invigorating blood circulation and eliminating stasis. The root of kudzu vine, the salviae miltiorrhizae and the ligusticum wallichii are compatible. The preparation meets compatibility principles of various drugs. However, kawasaki disease is systematic vascular inflammation which primarily induces infantile coronary artery injury. The preparation facilitates the preventionand treatment of coronary artery disease of kawasaki disease. The traditional Chinese medicine preparation is reasonable in formula compatibility, remarkable in effect, low in cost, small in side effect, obvious in curative effect after clinical application and worth being popularized.