124 results about "Mannuronic acid" patented technology

The invention discloses a leaf fertilizer composition comprising sodium alginate oligosaccharide, which is characterized in that the composition comprises sodium alginate oligosaccharide, amino acid and microelements that can promote plant growth significantly, wherein sodium alginate oligosaccharide is also known as sodium alginate, sea-tangle glue and algin, is natural polysaccharide carbohydrate extracted from sea tangle, and is a copolymer comprising a-L-mannuronic acid (M), b-D-guluronic acid (G) connected with a-L-mannuronic acid (M) by 1,4-glycosidic bond, and different GGGMMM fragments; a molecular formula is (C6H7O6Na)n; the degree of polymerization is 2-10; the uronic acid constitution M/G is equal to 7:3; the uronic acid content is greater than 90%, and is 2-3% of the total content; the content of a microelement leaf fertilizer is 2-20%; and the microelement leaf fertilizer comprises at least two of sulfur, boron, ferrum, manganese, copper, zinc and molybdenum. The composition is mainly applicable to industrial crops, fruit and vegetable crops, grain crops, economic trees, flowers, lawns and the like.

The invention relates to application of mannuronic acid oligose with carboxyl at a 1-position of a reducing end and a derivative to treatment of a Parkinson's disease. The mannuronic acid oligose and the derivative are particularly a compound or a pharmaceutically acceptable salt expressed by the following structural formula (II) in the description, wherein n in the formula (II) is one or more integers from 0-20.

The present invention is directed to a composition comprising high mannuronic acid-containing alginate and a polycation having a polydispersity index of less than 1.5. The composition is particularly useful for making biocompatible microcapsules containing living cells for allo- or xeno-transplantation. Such microcapsules have enhanced durability and can maintain their structural and functional integrity over long periods of time compared to prior art alginate microcapsules.

The invention relates to application of sodium alginate oligose and a derivative to treatment of vascular dementia. The sodium alginate oligose and the derivative of the sodium alginate oligose are particularly mannuronic acid oligose or mannuronic acid oligose with a carboxyl at a 1-position of a reducing end and the derivative or a pharmaceutically acceptable salt, formed by connecting a beta-D-mannuronic acid through a 1,4-glucosidic bond.

The invention provides essence cream realizing repairing at night. The essence cream realizing repairing at night comprises allantoin, EDTA-2NA, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, hyaluronic acid, hydrogenated polyisobutene, cetyl ethyl hexanoate, glyceryl stearate/PEG-100 stearate, polydimethylsiloxane, C14-22 alcohol/C12-20 alkyl glucoside, shea butter oil, tocopherol acetate, polydimethylsiloxane/dimethiconol, methyl silanol mannuronic acid ester/sodium methyl hydroxybenzoate/sorbic acid/ propyl hydroxybenzoate, water/butanediol/1,2-hexanediol/beta-glucan/phenoxyethanol, water/phenoxyethanol/algae extract, nicotinamide, water/propylene glycol/flos buddlejae extract, and dipotassium glycyrrhizinate. The essence cream belongs to emulsified ointment essencewith the efficacies of repairing skin injuries and realizing the moisturizing effect. The essence cream system realizing repairing at night is stable, realizes permeation and absorption easily, is refreshing but not greasy, can effectively repair injuries caused to the skin by sunlight, can balance the skin color, can resist skin ageing, realizes effective moisturizing, and realizes regenerating and nursing at night.

This invention relates to an extraction process of brown algae polysaccharides in a field of pharmaceutical chemistry. This invention particularly discloses a process of extracting brown algae polysaccharides based on a microwave chemistry method and brown algae polysaccharides obtained by said process. The process of the invention comprises: 1) putting pulverized brown algae powder into a microwave reaction chamber, adding acid solution to conduct reaction; optionally concentrating the mixer, and then washing with organic solvent to remove excess acid; conducting grading alcohol precipitation after water extract to obtain mannuronic acid rich fragment (M rich) algin, fucoidan and/or laminaran respectively; and adding an alkali solution to the brown algae residue to conduct alkaline digestion, filtering the residue off, adjusting pH of the filtrate to neutral, conducting alcohol precipitation to obtain guluronic acid rich fragment (G rich) algin precipitates. The present invention has significant advantages like fast processing rate, high yield of polysaccharides, strong controllable polysaccharide degradation, using less organic acid and efficient recovery, small water consumption, low power consumption, etc., the active polysaccharides has high yield and content, better water-soluble, and good biological activities.

The invention discloses a method for in-vitro amplification of tumor stem cells. The method comprises the following steps of carrying out in-vitro three-dimensional culture on tumor cells by an alginate gel support, and adjusting and controlling the rigidity of the alginate gel support by a change of support preparation parameters such as alginate molecular weight, a ratio (GM) of guluronic acid content to mannuronic acid content, a calcium ion concentration and calcification time, so that hardness of an in-vitro matrix in different tumor tissue microenvironments is simulated and in-vitro amplification of tumor stem cells in different tissue is realized. The method can be operated simply, has a low cost and controllable performances, can be industrialized and is a good method for in-vitro amplification on tumor stem cells having different sources.

The invention provides a use of low-molecular weight oligomannuronate in preparation of a drug or a health care product for preventing or treating Parkinson's disease. According to the invention, marine acidic polysaccharose as a raw material is prepared into a water-soluble low-molecular weight mannuronic acid compound. An experiment proves that the low-molecular weight mannuronic acid can be used for preventing and treating or improving Parkinson's disease, has obvious pharmacological effects and no toxic or side effects on nerve cells and can be taken for a long time. The low-molecular weight mannuronic acid is a marine natural product, has the advantages of rich resources, easy industrialization, high safety, unique structure and good oral absorption, and has a wide market application prospect in prevention and treatment of Parkinson's disease.

The invention provides application of mannuronic acid oligomers in preparing medicines, health products or dietary supplements for preventing and treating alcoholic liver injury. Mannuronic acid oligomers with different molecular weights, which are obtained by degrading polymannuronic acid graded and purified from algin, can lower the hepatosomatic index increase caused by alcoholic injury, resist triglyceride and cholesterol increase caused by alcohol, effectively lower glutamic-pyruvic transaminase and glutamic oxaloacetic transaminase increase in serum caused by alcohol, enhance the total oxidation resistance and glutathione level of the serum, lower the mouse drunkenness rate, prolong the mouse drunkenness time, and shorten the sober-up time, thereby implementing the protective action and hangover alleviating function on alcoholic hepatic injury. The products provided by the invention are derived from marine natural products, have the advantages of abundant resources, high industrialization tendency, high safety, high effectiveness and the like, and have wide development and application prospects in the aspects of prevention and treatment of alcoholic hepatic injury, hangover alleviation and liver protection.

The invention discloses a quality breeding method for sargassum fusiforme. The method comprises the steps that 1, ripe sargassum fusiforme alga bodies are selected to serve as main weeds, the quality ingredients of the main weeds are determined, and the main weeds of which the quality ingredients are in accordance with the following requirements are selected for seedling culturing, wherein the polysaccharide content, by dry weight, of the main weeds is larger than or equal to 40%, and the proportion sum of fucose, guluronic acid and mannuronic acid is larger than or equal to 80% by dry weight of the polysaccharide content of the sargassum fusiforme; 2, after the main weeds which are in accordance with the quality requirements are collected, lower alga bodies of the main weeds are removed, upper and middle alga bodies are retained, a female plant and a male plant are combined into a pair and put in a seedling culturing pool to be cultured for five to eight days, sperms and eggs are released and fertilized to form young embryos, and the young embryos are collected. According to the quality breeding method for the sargassum fusiforme, the breeding effect of the sargassum fusiforme can be significantly improved, the sargassum fusiforme obtained through the breeding method is more uniform in quality and good in breeding effect, the main weeds can be randomly selected for breeding, and the breeding quality of the main weeds is stable.

The invention belongs to the field of natural medicine chemistry and quality control, and relates to a method for measuring the weight-average molecular weight and the content of soluble salt of mannuronic acid substances. Weight-average molecular weight and content results of acid sugar measured by an SEC-MALS (size exclusion chromatography with multi-angle laser scattering detector) are corrected by the aid of the metal ion content of soluble salt samples of the mannuronic acid substances. The weight-average molecular weight and the content of the soluble salt w of the mannuronic acid substances can be rapidly and accurately measured by the method.

The invention discloses a broad-spectrum flower and fruit protector for plants and application of the broad-spectrum flower and fruit protector. An active component of the broad-spectrum flower and fruit protector adopts alginic acid oligosaccharide or an alginic acid oligosaccharide derivative; the alginic acid oligosaccharide is oligosaccharide obtained by connecting mannuronic acid with guluronic acid through a beta-1,4-glucosidic bond, and the molecular weight of the alginic acid oligosaccharide is 300 to 10,000 Da; the alginic acid oligosaccharide derivative comprises an alginic acid oligosaccharide sulfuric acid derivative and an alginic acid oligosaccharide phosphorus-containing derivative. The broad-spectrum flower and fruit protector is applied to increasing the flower protection and fruit setting rate in growing and developing processes of vegetables and fruit trees; the broad-spectrum flower and fruit protector is applied to the vegetables and the fruit trees. By the use of the broad-spectrum flower and fruit protector, the fruit setting rate can be increased by 40 to 80 percent, and particularly, the fruit setting rate of the vegetables is increased by 30 to 80 percent. A drug with the alginic acid oligosaccharide serving as a main component has the advantages of safety, nontoxicity, low cost, small application amount, environment friendliness, durable effect and the like. The broad-spectrum flower and fruit protector for the plants is used for carrying out application, seed soaking, root dipping, root irrigation and the like on crops such as the fruit trees, so that the flower and fruit protection capacity of the crops can be improved, and the broad-spectrum flower and fruit protector has an outstanding effect on increase of the crop yield and improvement of the quality.

The invention provides oligomerization mannuronic acid and application of medicinal salts of oligomerization mannuronic acid in leucopenia prevention medicine. In in-vitro cell experiments, oligomerization mannuronic acid can obviously promote forming of colony-forming unit-granulocyte macrophage (CFU-GM), simultaneously can promote marrow stroma cells to breed and secrete CFU-GM and promote splenic lymphocytes to secrete interleukin-3. In vivo experiments further indicates that oligomerization mannuronic acid can obviously restrain reduction of white blood cells in mice caused by cyclophosphamide, increase the number marrow nucleated cell of the mice and promote forming of CFU-GM. Experiment results indicate that oligomerization mannuronic acid can be developed to be a clinical medicine capable of effectively preventing leucopenia.

The invention provides application of oligomeric mannuronic acid to preparation of a medicine for resisting influenza A virus subtype H1N1. Through experiment, the oligomeric mannuronic acid (OM) has a good function of protecting madin-darby canine kidney cells which are infected by influenza A virus subtype H1N1 in vitro, can effectively reduce virus reproduction, and has an effect equal to thatof a positive control medicine ribavirin. Moreover, OM can also reduce the death of mice which is caused by infection of influenza A virus subtype H1N1 obviously, and prolong the survival time. The oligomeric mannuronic acid (OM) has the advantages of high water solubility and stability, and safety and low toxicity and the like; and in an in vivo-in vitro experiment, the OM can resist influenza Avirus subtype H1N1 well, and the oligomeric mannuronic acid can be expected to be developed to the medicine for resisting influenza A virus.