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Algin oligose and derivative thereof and producing method and use thereof

A technology for oligosaccharides and derivatives of alginate, applied in the directions of oligosaccharides, drug combinations, pharmaceutical formulations, etc., can solve problems such as difficulty in obtaining oligosaccharides, application limitations and the like

Active Publication Date: 2009-07-08
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical degradation methods used for sugar degradation mainly include acid hydrolysis and oxidative degradation. However, because the conventional acid hydrolysis is carried out at normal temperature and pressure, it is difficult to obtain oligosaccharides with a molecular weight below 4000, which limits its application.

Method used

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  • Algin oligose and derivative thereof and producing method and use thereof
  • Algin oligose and derivative thereof and producing method and use thereof
  • Algin oligose and derivative thereof and producing method and use thereof

Examples

Experimental program
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Embodiment Construction

[0041] (1) Preparation of alginate oligosaccharides:

[0042] Weigh 1g of polymannuronic acid sodium salt (weight average molecular weight 8,235Da, provided by Lantai Pharmaceutical Co., Ltd., Ocean University of China), add distilled water to make a 1% solution, adjust the pH value to 4 with hydrochloric acid, and place in an autoclave , heated at 110°C for 4 hours. After taking it out and cooling it, adjust the pH value to 7 with NaOH solution, while stirring, slowly pour the filtrate into industrial alcohol 4 times the volume of the filtrate, let it stand still, and alcohol settle overnight. The alcohol-precipitated substance was suction-filtered to dryness, washed and dehydrated with absolute ethanol, and the obtained white filter cake was dried in an oven at 60°C to obtain crude algin oligosaccharides.

[0043] Take the crude product of alginate oligosaccharides, make a 10% solution, use 95% ethanol solution to precipitate, wash the precipitate with absolute ethanol, dry i...

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PUM

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Abstract

The present invention provides algin oligosaccharides having polymerized degree of 2-22 and the derivatives thereof, such algin oligosaccharides are made of mannuronic acid bonded by [proportional to]-1,4 glycosidic bond. The derivatives which the reduced terminal in position-1 is carboxyl radical can be obtained by oxidation. The invention also provides the manufacture of algin oligosaccharides and the derivatives thereof, which includes the alginate solution in water reacts in the reactor under the condition of high press, 100-120 DEG C, pH2-6, for 2-6 hours, after the reaction completed, its pH value was adjusted to 7. The result oligosaccharides are oxidated in presence of the oxidant, and then produces the oxidated products. The algin oligosaccharides and the derivatives thereof of the invention can be used in the manufacture of medicaments for preventing Alzheimer's dementia and diabetes.

Description

technical field [0001] The invention relates to a kind of algin oligosaccharide and its derivatives, their production method and their application in the treatment of senile dementia and diabetes. Background technique [0002] Senile dementia and diabetes are frequently-occurring and common diseases that seriously endanger human health at present. Especially with the increasing number of elderly people in the world, their incidence is increasing year by year. Therefore, the prevention and treatment of senile dementia and diabetes is becoming more and more important. more important. [0003] Drugs currently used for the prevention and treatment of senile dementia include central stimulants, substances that improve cholinergics, agents that improve cerebral blood circulation, Chinese herbal medicines, and pyrrolidone compounds, etc. Most of them have inaccurate curative effects, low specificity, or large toxic and side effects. Oral absorption is poor, it is not easy to pass ...

Claims

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Application Information

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IPC IPC(8): A61K31/702C08B37/00C07H3/06A61P25/28A61P3/10
Inventor 耿美玉辛现良孙广强管华诗杨钊
Owner OCEAN UNIV OF CHINA
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