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Drug coating stent based on HIV protease inhibitor saquinavir as well as preparation method and application thereof

A protease inhibition and drug coating technology, applied in the field of bioengineering, can solve the problem that the incidence of peripheral vascular restenosis is not significantly reduced, and achieve the effects of inhibiting the proliferation of vascular smooth muscle, inhibiting matrix degradation, and inhibiting immunity

Inactive Publication Date: 2015-06-17
袁洪 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the use of the current antiproliferative drug-coated stent, the restenosis of coronary vessels has been improved, and the restenosis rate has dropped from 30-50% to 15%, but the incidence of peripheral vascular restenosis has not been significantly reduced

Method used

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  • Drug coating stent based on HIV protease inhibitor saquinavir as well as preparation method and application thereof
  • Drug coating stent based on HIV protease inhibitor saquinavir as well as preparation method and application thereof
  • Drug coating stent based on HIV protease inhibitor saquinavir as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A drug-coated stent of the present invention, such as figure 1 As shown, it includes a base stent 2 (the base stent is a hole-type metal stent, and the number of holes on the base stent is 600) and a drug coating 1 coated on the surface of the base stent 2; the drug coating 1 contains the drug saquinavir and the matrix methacrylic resin, the thickness of the drug coating 1 is 100 μm, and the mass ratio of the drug saquinavir to the methacrylic resin in the drug coating 1 is 1:1.

[0031] The preparation method of the above-mentioned drug-coated stent, the main steps are: weigh 40g of methacrylic acid resin and 40g of saquinavir, add 40g of water (add 1g of concentrated HCL to the water) and mix evenly to prepare a uniform sol; The drug-coated stent is obtained by soaking in the prepared sol, drying and curing to form a film.

[0032] The drug-coated stent in this implementation was applied in vascular interventional surgery, and carotid filaments were injured at the ca...

Embodiment 2

[0039] A drug-coated stent of the present invention, such as figure 1 As shown, it includes a base stent 2 (the base stent is a hole-type metal stent, and the number of holes on the base stent is 600) and a drug coating 1 coated on the surface of the base stent 2 . Drug coating 1 contains drug saquinavir, drug rapamycin and matrix methacrylic acid resin, the thickness of drug coating 1 is 100 μm, drug saquinavir and drug rapamycin in drug coating 1 The mass ratio of the total mass to the methacrylic resin is 1:1.

[0040] The preparation method of the above-mentioned drug-coated stent includes the following steps: weighing 40 g of methacrylic acid resin, 20 g of saquinavir and 20 g of rapamycin, adding 40 g of water (adding 1 g of concentrated HCL to the water) and mixing uniformly to obtain a uniform Sol; and then soak the base stent in the prepared sol, and after drying and curing to form a film, the drug-coated stent is obtained.

[0041] Applying the drug-coated stent of...

Embodiment 3

[0043] A drug-coated stent of the present invention, such as figure 1 As shown, it includes a base stent 2 (the base stent is a hole-type metal stent, and the number of holes on the base stent is 600) and a drug coating 1 coated on the surface of the base stent 2 . Drug coating 1 contains drug saquinavir and matrix polylactic acid, the thickness of drug coating 1 is 100 μm, and the mass ratio of drug saquinavir and polylactic acid in drug coating 1 is 1:2.

[0044]The preparation method of the above drug-coated stent comprises the following steps: weighing 40g of polylactic acid and 20g of saquinavir, adding 40g of water and mixing uniformly to obtain a uniform sol; then soaking the matrix stent in the prepared sol, and curing by drying After film formation, the drug-coated stent is obtained.

[0045] Applying the drug-coated stent of this embodiment in vascular interventional surgery can control vascular inflammation and prevent the occurrence of intravascular restenosis; th...

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Abstract

The invention discloses a drug coating stent based on HIV protease inhibitor saquinavir. The drug coating stent comprises a base support and a drug coating which coats the surface of the base support, wherein a drug and a base material are contained in the drug coating; the drug comprises saquinavir. The invention also discloses a preparation method of the drug coating stent: adding the polymer base material and the drug to water, and uniformly mixing to prepare uniform colloidal sol; then soaking the base support in the colloidal sol, and then forming a film through drying and curing to obtain the drug coating support. The drug coating stent based on HIV protease inhibitor saquinavir is applied to endovascular intervention operations, and can control vascular inflammation and prevent the occurrence of vascular restenosis.

Description

technical field [0001] The invention belongs to the field of bioengineering, and in particular relates to a drug-coated stent based on HIV protease inhibitor saquinavir and a preparation method and application thereof. Background technique [0002] Endovascular surgery, such as endarterectomy, peripheral arterial interventional angioplasty, coronary angioplasty, and stenting, is widely used to treat arterial occlusive disease, often due to in-stent restenosis leading to re-occlusion of the blood vessel. Long-term effects of surgery significantly decreased. These vascular interventional procedures can easily lead to endothelial denudation, vascular intima damage, and cause a large amount of local inflammation. This inflammation is caused by mononuclear cell infiltration leading to the production of inflammatory mediators and growth factors, resulting in the accumulation of vascular smooth muscle cells and deposition of extracellular matrix, intimal hyperplasia, and vascular ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16
Inventor 袁洪蔡菁菁提摩西·罗伯特·彼尼尔陈丰原陆瑶肖婷钟华
Owner 袁洪
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