93 results about "In utero" patented technology

The invention relates to methods for reducing a condition associated with fetal alcohol syndrome in a subject who is exposed to alcohol in utero with an ADNF polypeptide (e.g, ADNF I polypeptides, ADNF III polypeptides, or mixtures of ADNF I and ADNF III polypeptides). In one embodiment, the present invention relates to methods for reducing a condition associated with fetal alcohol syndrome in a subject who is exposed to alcohol in utero with a mixture of ADNF I and ADNF III polypeptides. The present invention further relates to methods for reducing neuronal cell death by contacting neuronal cells with a mixture of ADNF I and ADNF III polypeptides. Still further, the present invention relates to a pharmaceutical composition comprising a mixture of ADNF I and ADNF III polypeptides.

The present invention is a method and apparatus for applying a focused, directed audio beam at a fetus to stimulate the fetus in utero. An ultrasound signal is amplitude modulated with an audio range signal, and directed to an ultrasound transducer positioned on the abdomen of a pregnant woman. A focused beam from the ultrasound transducer is directed at the head of a fetus, wherein the resultant audio signal stimulates the middle ear, causing the fetus to move. Motion of the fetus can be tracked to test hearing in individual ears or to test the general health of the fetus. Furthermore, the focused beam can be successively directed at the fetus to cause to the fetus to move to a selected location in the womb for clinical testing or delivery.

A method for achieving a chronobiologic effect on a circadian rhythm in a human infant or fetus in utero is described. The method involves the administration of melatonin or dose-equivalent melatonin analogue or melatonin receptor agonist to an infant by administering melatonin or dose-equivalent melatonin precursor, melatonin analogue or melatonin receptor agonist to the infant's breast-feeding mother or wet nurse, and to a fetus by administration of melatonin or dose-equivalent melatonin precursor, melatonin analogue or melatonin receptor agonist to the pregnant woman. Alternatives wherein melatonin or dose-equivalent melatonin analogue or melatonin receptor agonist is administered directly to the infant, such as in formula or in expressed breast milk, are also provided.

An method and apparatus for using polymerizable hydrogels to cause tracheal obstruction (TO) for treatment of pulmonary hypoplasia disorders to improve lung development in-utero. Use of the compound can cause effective TO for the purposes of inducing lung growth.

Described herein are methods of preparing human amniotic membrane tissue grafts derived from the placenta. The grafts are composed of three layers as seen in the amniotic membrane in utero. These grafts are processed using physiologic solutions, lyophilized and terminal sterilized (via gamma irradiation in a frozen state) that thereby preserves the graft in such a manner as to retain the naturally occurring biological properties of the amniotic membrane and offer a sterile graft for transplantation. By dehydration via lyophilization and terminal sterilization in a frozen state, the graft has the advantage of storage at ambient temperatures for prolonged periods of time prior to transplantation.

The invention relates to Lactobacillus reuteri DSM 17938, and compositions comprising Lactobacillus reuteri DSM 17938, for promoting the healthy development and / or repair of the enteric nervous system in mammals. Humans or animals and, in particular, a foetus, pre-term or term-born infant, toddler or child may benefit from the invention. The invention may be especially beneficial to those infants having experienced IUGR, or having a low, or very low birth weight, and / or suffered from enteric nervous system growth retardation either in utero or, during or after birth. The administration of to Lactobacillus reuteri DSM 17938 promotes normal and healthy neuronal and glial development. It also ensures healthy neuronal differentiation in the peripheral nervous system.

A compact fetal sound system delivers high-fidelity sound to a fetus in utero through a miniature, abdominally mounted driver with a convex diaphragm. No gel is necessary at the interface between the diaphragm and the mother's abdomen. Digital signal processing shapes the frequency spectrum of the sound transmitted to the fetus, so that after traveling through the attenuative tissue of the expectant mother the desired volume of sound and frequency content reach the ears of the fetus. As the term of pregnancy progresses, the frequency shaping provided by the digital signal processing automatically varies to compensate for changes in uterine lining thickness and the like. Preferred embodiments also include a microphone attached to the abdomen of the mother and signal processing to correct for frequency and amplitude distortions of sound eminating from the womb. Embodiments also include an elastic belt to maintain the transducer and microphone against the abdomen.

The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin. The present invention further relates to the use of such animals as models of various liver diseases, including viral invention. Such embodiments are based on the discovery that transplanted human hepatocytes in chimeric livers were found to be susceptible to Hepatitis B virus and Hepatitis C virus infection.

The invention discloses a fetal brain age estimation and anomaly detection method and device based on deep learning. The brain age estimation and anomaly detection method comprises the following steps: firstly, establishing a data set of T2 weighted magnetic resonance images of the brain of a normal fetus by utilizing T2 weighted images in the uterus of a pregnant woman, which are collected clinically and conventionally; secondly, segmenting the brain of the fetus from the uterus by using a U-shaped network, predicting the brain age of the fetus by using a deep residual network based on an attention mechanism, and generating the uncertainty of the brain age and the credibility of the estimation of the brain age of the fetus; and finally, constructing a classifier according to the difference, uncertainty, credibility and other indexes of the actual fetal age and the predicted brain age, and judging whether the brain development of the fetus is abnormal or not. According to the method, the brain age of the fetus can be estimated at the same time, indexes such as uncertainty and estimation credibility are generated to be used for detecting the fetus with abnormal brain development, and the method and device have high accuracy and precision and high clinical application prospect and value.

The invention discloses an intelligent baby crib, which comprises a bed body, a bed board and supporting legs, wherein the bed body is in an ellipsoid shape with an opening in the upper portion. The lower end of the bed body is connected with the bed board; a memory mattress is laid on the bed board and used for simulating the environment of a baby in uterus amniotic fluid. The baby crib is further provided with a sound sensor used for monitoring sounds made by a baby, a music player with voice recording and playing functions and a camera. Music for simulating blood flow in the uterus and multiple types of music customized corresponding to various states of the baby are preset in the music player. The sound sensor and the camera are used for acquiring the posture of and the made sound of the baby respectively and uploading the data to the server to analyze the posture type and crying type of the baby; and the server controls the music player to enter different sleep inducing working modes through big data of baby postures and cry types, and corresponding music preset in the music player is played. The baby crib has the function of automatically pacifying the baby, and time of family members is saved.