177 results about "Gamma irradiation" patented technology

The invention relates to a product comprised of specific combinations of cell lines intended for use as an allogeneic immunotherapy agent for the treatment of prostate cancer in humans. The heterogeneity of the immunotherapeutic matches the heterogeneity of the antigenic profile in the target prostate cancer and immunises the recipients with many of the potential TAA and TSA which are expressed at various stages of the disease. The invention discloses a vaccine comprising a combination of three different cell lines prepared from primary or metastatic prostate cancer biopsy material. The cell lines are lethally irradiated utilising gamma irradiation at 50-300 Gy to ensure that they are replication incompetent.

Scintillator material comprising nanoparticles (nanocrystals) comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) wherein the nanoparticles exhibit room-temperature scintillation under gamma irradiation. The scintillator nanoparticles can comprise Pb₃O₂I₂. The scintillator nanoparticles can comprise PbIOH in generally equiatomic proportions or non-equiatomic variants thereof that exhibit scintillation under gamma irradiation. The scintillator nanoparticles have a particle dimension in the range of about 5 to about 100 nm. Microparticles (microcrystals) also are provided comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) grown in a nanoparticle colloidal solution over time to a particle dimension greater than 0.1 μm, such as about 2 microns. A heterogeneous scintillator material is provided comprising core/shell nanoparticles having a highly hygroscopic or deliquescent halide-based core activated with trivalent Ln³⁺ or divalent Ln²⁺ lanthanide ions (Ln=La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and a stable non-hygroscopic shell thereon. The heterogeneous nanoparticles can comprise highly hygroscopic lanthanide halide (LaBr₃, LuI₃) cores protected with stable non-hygroscopic LaF₃ shells. The heterogeneous nanoparticles can comprise deliquescent alkaline earth halide (SrI₂, BaI₂) cores protected with stable non-hygroscopic (SrF₂, BaF₂) shells.

The present invention provides a method sterilizing butyl rubber/styrene butadiene rubber (SBR) articles used in syringes or medical containers, comprising irradiating the butyl rubber/SBR elastomeric copolymer rubber article with gamma irradiation, wherein the SBR elastomeric copolymer comprises about 5% to about 50% of the rubber composition on a basis of total weight of the composition; and then exposing the irradiated rubber composition to a sterilizing gas for a time period sufficient to sterilize the rubber composition. The irradiated, sterilized rubber composition of the present invention is capable of maintaining superior performance standards with respect to sealability, recoverability from stress and elasticity.

The invention relates to the field of drug development against acute radiation injury caused by exposure to high-energy electromagnetic waves (X-rays, gamma rays) or particles (alpha particles, beta particles, neutrons). To date, there is no effective drug to ameliorate radiation injury after accidental exposure to ionizing irradiation. The invention provides a method of treating radiation injury of a subject in need thereof comprising administering to the subject a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids. Furthermore, the invention provides use of a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids for the production of a pharmaceutical composition for the treatment of a subject suffering from or believed to be suffering from radiation injury. In particular, the invention provides anti-radiation peptides having a dose reduction factor (DRF) against acute gamma irradiation of at least 1.10, said DRF determinable by testing which dose of radiation results in 50% mortality at 30 days (LD50/30) after whole body radiation (WBI) in a test group of mice treated with said peptide at 72 hours after WBI and, testing which dose of radiation results in 50% mortality at 30 days (LD50/30) after whole body radiation (WBI) in a control group of mice treated only with the vehicle of said peptide at 72 hours after WBI and wherein the DRF is calculated by dividing the LD50/30 of the peptide-treated animals by the LD50/30 of the vehicle-treated animals.

A method for inhibiting adverse reaction of the contents of a prefilled container during a radiation sterilization procedure is disclosed. In the method, a container which is made of a material including a radiation stable polyolefin is prefilled with a medium prior to being subjected to a gamma irradiation sterilization treatment. By using a radiation stable polyolefin material as the container, such as a polyolefin with a radiation stabilizer additive, and by prefilling the container prior to the gamma irradiation treatment, the container can be effectively sterilized without adversely affecting its contents.

Described herein are human amniotic membrane tissue grafts derived from the placenta. The grafts are composed of three layers as seen in the amniotic membrane in utero. These grafts are processed using physiologic solutions, lyophilized and terminal sterilized (via gamma irradiation in a frozen state) that thereby preserves the graft in such a manner as to retain the naturally occurring biological properties of the amniotic membrane and offer a sterile graft for transplantation. By dehydration via lyophilization and terminal sterilization, the graft has the advantage of storage at ambient temperatures for prolonged periods of time prior to transplantation.

The invention discloses a medicinal low-temperature-resistant toughening anti-gamma ray impact-resistant transparent polypropylene material and a preparation method thereof. The medicinal low-temperature-resistant toughening anti-gamma ray impact-resistant transparent polypropylene material is prepared by completely mixing a base material, a flexibilizer, a gamma shielding auxiliary agent, a transparent nucleating agent, an antioxidant, a lubricant, a brightening agent and a molecular weight regulator according to the proportion, wherein homopolymerized polypropylene serves as the base material. An ethylene-octylene-propylene ternary random copolymer is adopted, so the medicinal low-temperature-resistant toughening anti-gamma ray impact-resistant transparent polypropylene material has excellent toughness and impact resistance and low-temperature resistance, is transparent, and fundamentally solves the problem that a medicinal polypropylene material is not transparent. A reactive type hindered amine stabilizing agent is grafted on a polypropylene molecular chain by a reaction extrusion method, so the gamma ray resistance is improved. After the medicinal polypropylene material prepared by the method is subjected to 25-kilojoule gamma irradiation, the yellowing index is less than 1; and then a moulding part is placed in a 70-DEG C baking oven for 8 weeks, the yellowing index is 3, the comprehensive mechanical property is reduced by 5 percent, and the transparency maintains over 90 percent.

A mushroom and cordyceps militaris extract flavoring and a preparation method thereof. The mushroom and cordyceps militaris extract flavoring comprises monosodium glutamate, mushroom submicron powder, maltodextrin, yeast extract, disodium 5'-ribonucleotide, hydrolyzed vegetable protein, disodium succinate, powdered oil and the like. The preparation method comprises the following steps of cleaningmushrooms and cordyceps militaris extract, drying them by an oven, sieving the dried mushrooms and the cordyceps militaris extract, crushing the sieved mushrooms and the cordyceps militaris extract into superfine powder having the size less than 10 micrometers, mixing well the superfine powder and other crushed materials with stirring, granulating by rotation, drying by a fluidized bed, grading by vibration, packaging automatically, and carrying out sterilization by gamma irradiation at a dose of 3KGy. The preparation method adopts ultra-microprocessing of mushrooms and cordyceps militaris extract to realize that taste-producing substances and nutrient components are released fully, and thus a delicate flavor is increased and an absorption rate of nutrients is improved. Through reasonableproportions and interaction of superfine powder and powdered oil, a unique delicious taste is obtained. Through a fluidized bed drying technology, materials are heated uniformly; heating time is short; temperature-sensitive components in a condiment are retained; energy consumption is low; and product quality is stable. Through irradiation sterilization, a shelf-life of two years can be realized.

The invention relates to the field of medical biological dressings, in particular to a GelMA hydrogel human acellular amniotic membrane three-dimensional two-layer dressing preparation method which isa method for preparing a GelMA hydrogel/human acellular amniotic membrane three-dimensional two-layer dressing through integration of electrostatic spinning and photo-crosslinking. The method includes: subjecting gelatin to MA (methylacrylic acid) graft modification to form GelMA, covering D-HAM (decellularized human amniotic membrane) with GelMA in a porous fiber form through electrostatic spinning to obtain the three-dimensional two-layer bioactive dressing, and subjecting the dressing to photo-crosslinnking with a photoinitiator Irgacure2959; lyophilizing the dressing subjected to photo-crosslinnking, performing gamma irradiation sterilization, and packaging under sterile conditions. Great anti-inflammation and anti-infection effects and high biocompatibility are achieved, and quick healing of oral mucous wounds can be promoted.

A broad spectrum disinfectant includes a quaternary ammonium halogen, an alkaline agent, a chelating agent, a nonionic surfactant coupler, at least one alkoxylated nonionic surfactant, and water or any aliphatic alcohol. The disinfectant composition is phenol-free, is effective in eradicating microorganisms such as various fungi, and is stable to gamma-irradiation.

Disclosed are freeze-dried plasma formats specifically designed for the trauma care field. Blood plasma is subjected to a glucose removal step, a protein fraction up-concentration step and addition of stabilizers prior to freeze-drying. Preferable stabilizers are glutamine dipeptides, glutamine and glycine. The glutamine based formulation is added direct to plasma and serves three main purposes: 1) Increases stability of plasma proteins and stabilizes pH in freeze-dried state; 2) Increases stability of plasma proteins against Gamma Irradiation and thus allows for the application of a terminal sterilization step; 3) Introduces supplements beneficial to the trauma patient.

The present invention relates generally to methods of sterilizing elastomeric articles in a manner that prevents and/or reduces degradation to the articles, particularly degradation that may be caused and/or accelerated by sterilization techniques such as gamma irradiation, x-ray irradiation, and electron-beam processing. The methods include packaging the elastomeric articles in order to improve their resistance to degradation. In certain aspects of the invention, packaged elastomeric articles, optionally containing one or more antidegradants, such as antioxidant and/or antiozonant compounds, are also provided. The methods of providing degradation-resistant elastomeric articles in accordance with the present invention may also be used to reduce the occurrence of cracking and discoloration in elastomeric articles, regardless of whether they are subjected to sterilization.

Scintillator material comprising nanoparticles (nanocrystals) comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) wherein the nanoparticles exhibit room-temperature scintillation under gamma irradiation. The scintillator nanoparticles can comprise Pb₃O₂I₂. The scintillator nanoparticles can comprise PbIOH in generally equiatomic proportions or non-equiatomic variants thereof that exhibit scintillation under gamma irradiation. The scintillator nanoparticles have a particle dimension in the range of about 5 to about 100 nm. Microparticles (microcrystals) also are provided comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) grown in a nanoparticle colloidal solution over time to a particle dimension greater than 0.1 μm, such as about 2 microns.

The invention discloses an array-type gamma irradiation dosimeter of a FBAR structure on a diaphragm. The array-type gamma irradiation dosimeter comprises a detection element, a composite thin film, and a Si substrate. The detection element is disposed on the upper part of the composite thin film, and the composite thin film is used to support the detection element, and the Si substrate is disposed on the lower part of the composite thin film. The detection element comprises a plurality of FBAR, which are in an array-type arrangement, and are disposed on the composite thin film. Each of the FBAR comprises, from bottom to top, a bottom electrode, a piezoelectric layer, and a top electrode sequentially. An irradiation sensitive layer is disposed between each of the piezoelectric layers and each of the bottom electrodes, or is disposed between each of the piezoelectric layers and each of the top electrodes, and the bottom electrodes are tightly attached to the upper surface of the composite thin film. The Si substrate is provided with a plurality cavities, which are respectively corresponding to the irradiation sensitive layers in a vertical direction. The cavities are used to form the volume acoustic wave reflection interfaces, and the composite thin film areas corresponding to the cavities are the composite thin film suspension areas. The array-type gamma irradiation dosimeter has advantages of small size, high sensitivity, good temperature stability, good manufacturability, and ability of detecting irradiation dose distribution.