A production formula of health-care wine includes distilled wine and traditional Chinese medicine raw materials. The distilled wine is prepared from wheat, corn, sorghum, black rice, buckwheat, oat, highland barley and dried sweet potato. The traditional Chinese medicine raw materials include ginseng, pilos antler, radix angelica sinensis, wolfberry, jujube, tortoise plastron, glossy privet fruit,ganoderma lucidum, honey, radix puerariae, rhizoma polygonati, radix astragali, ophiocordyceps sinensis, arillus longan, eucommia ulmoides, radix salviae miltiorrhizae, ligusticum wallichii, preparedrehmannia root, rock candy, and penis cervi. The preparation method of the health-care wine comprises three steps. The whole materials of the distilled wine do not contain substances harmful to a human body, and the quality and the drug efficacy of the finished product can be guaranteed. The product is prepared by adding distilled wine to various traditional Chinese medicine raw materials being harmless and non-toxic to the human body and then soaking is easy to drink, lower in alcoholicity, sweet and fragrant in taste and suitable for all ages. After health-care wine is drunk, the health-care wine can play a health-care effect on the body, can obviously improve the human immunity, enhances metabolism mechanism and enhances the human vitality.