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38 results about "Fetal brain" patented technology

System and method for fetal brain monitoring

A system for monitoring a brain wave response of a fetus in utero, comprises removably connecting an auditory transducer, including at least one biosensor electrode, producing pulsed auditory sounds to a mother's abdomen to detect brain wave activity in a fetus. The transducer is pulsed with one of rectangular waves and tone pips of a selected frequency to emit pulsed audible sounds at predetermined times. The at least one biosensor electrode, including connected amplifier, detects brain stem auditory responses (BAER) of the fetus. For each pulsed audible sound a series of voltage oscillations corresponding to BAER of the fetus are time-locked to the corresponding audible sound. BAER analog output is converted to BAER digital data. A computer-based QEEG (Quantitative EEG) system improves a signal to noise ratio of the BAER digital data using an adaptive optimum filtering algorithm and analyzes the BAER digital data relative to a reference database.
Owner:NEW YORK UNIV

Formula milk powder containing arachidonic acid for pregnant and parturient women and preparation method thereof

ActiveCN102488011AGood for brain and optic nerve developmentImprove the deficiency of essential fatty acidsMilk preparationVegetable oilPhysiology
The invention relates to formula milk powder containing arachidonic acid for pregnant and parturient women and a preparation method thereof. The formula milk powder is composed of the following components in percentage by weight: 40-50% of skimmed milk, 10-14% of desalinated whey, 8-12% of carbohydrate, 8-12% of milk protein, 6-10% of white granulated sugar, 4-7% of vegetable oil, 3-6% of fructooligosaccharides, 0.5-1% of mineral matter, 0.5-1% of water-soluble vitamin premix, 0.5-1% of soybean phosphatide, 0.5-1% of essence, 0.3-0.6% of docosahexaenoic acid, 0.1-1% of arachidonic acid, less than 0.1% of taurine and 0.01-0.04% of fat-soluble vitamin premix. According to the invention, the formula milk powder is richer in nutrition, is favorable for the development of the fetal brain and optic nerve, and can improve the phenomenon of essential fatty acid deficiency caused by pregnancy and lactation of mothers.
Owner:AUSNUTRIA DAIRY CHINA

Image processing method for automatically judging fetal hydrocephalus from ultrasonic images

The invention provides an image processing method for automatically judging fetal hydrocephalus from ultrasonic images, comprising the following steps: firstly extracting skull ellipse of a new fetal brain image on the second plane, lateral ventricle horizontal plane; establishing a space histogram pyramid in the interior zone of the ellipse in the image; respectively calculating the distances among the space histogram pyramids of the given fetal ultrasonic image, the normal fetal brain images in the same gestational week and the image of hydrocephalus in the brain on the lateral ventricle horizontal plane in the same gestational week; and setting a threshold and giving the possibility of fetal hydrocephalus from judgment according to the relationship between the distances among the space histogram pyramids and the threshold.
Owner:SHENZHEN MATERNITY & CHILD HEALTHCARE HOSPITAL +1

Device for recording ultrasound-induced fetal eeg, and method of use

A portable device utilizes an ultrasound probe, which is placed on the abdomen of a mother and allows ultrasound video and pictures, as well as Doppler heartbeat detection of the fetus. It is also capable of recording fetal brain activity induced by constant-wave or pulsed-wave ultrasound stimuli; and analyzing the fetal EEG measurements. The electrical brain waves are detected by a sensor, amplified, digitized, and analyzed in one portable device, using analog and / or digital filters to improve the signal / noise ratio. The portable computer uses augmented reality imaging and quantitative EEG analysis software to compare the data from the fetus to normative data or to prior states of the fetus' own data. The EEG signals are recorded for an extended period of time and can be analyzed in real time or at a later time for rhythmicity patterns indicative of epilepsy or other developmental brain disorders.
Owner:KIRALY MARIANNA

Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
Owner:KIRIN PHARMA +1

Ultrasound and photoacoustic systems and methods for fetal brain assessment during delivery

Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (US) and photoacoustic (PA) signals between the probe device and fetal brain, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.
Owner:WAYNE STATE UNIV

Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
Owner:KIRIN PHARMA

Method for positioning three axial positions of fetal brain through nuclear magnetic resonance

The invention relates to a method for positioning three axial positions of a fetal brain through magnetic resonance. The method is used for further rapidly, accurately and normatively positioning an image of the three axial positions of the fetal brain on the basis of the traditional nuclear magnetic resonance scanning and positioning technology and providing a more accurate and normative cross-section image for clinical medicine. Because the position and the direction of a fetus in a parent are possibly changed at any time, the standard three axial positions of only a few fetuses can be directly positioned through the standard three axial positions of the parent; in many cases, the position of the fetus in the parent is changeable; the standard image of the three axial positions cannot be obtained through the traditional technology; when the standard three axial positions of the parent cannot be given or the standard three axial positions of the fetus cannot be better given, a series of images of various positions can be obtained by rotating and positioning in 360 DEG through a haste sequence, namely a heavy T2 weighted line; and the image closest to the standard fetal position is selected from the series of images and served as the standard to position the brain.
Owner:THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA

Electronic device for promoting fetal brain development and method thereof

The invention relates to an electronic device for promoting fetal brain development and a method thereof, the device comprises a housing, a CPU, a memory module, an image decoding module, a display screen, buttons, an audio decoding module, a digital volume control circuit, a digital filter circuit, a sound effect module, a manual adjustment volume control circuit, a power amplifier module and a speaker, wherein the memory module, the image decoding module and the audio decoding module are in connection and communication with the CPU, and the display screen is connected with the image decoding module; the audio decoding module, a digital sound effect module-digital filter module or the digital filter module-the digital sound effect, the sound effect module, the power amplifier module and the speaker are serially connected; and the audio decoding module, the manual adjustment volume control module, the power amplifier module and the speaker are serially connected. The method uses the device for realizing fetal education, including input of pregnancy data by a user, selection of items of the fetal eduction, calling of the fetal eduction data by the device for processing audio signals and output of audio and video, and a pregnant woman can operate according to the prompts of the video. The electronic device can better meet the requirements of fetal auditory development on volume and frequency of music stimulation, ensure the effectiveness and the safety of the fetal education and be simple and convenient to use.
Owner:孟奇志

Microencapsulated peony seed oil, compound composition and preparation method of microencapsulated peony seed oil

InactiveCN106900885AHigh yield of microencapsulationGood storage stabilityFood freezingFood shapingDiseaseAnimal science
The invention provides microencapsulated peony seed oil, compound composition and a preparation method of the microencapsulated peony seed oil. The microencapsulated peony seed oil is prepared from a peony seed oil core material and a Maillard product wall material and has good antioxidant effect. The microencapsulated peony seed oil is taken as a raw material and compounded with folic acid and xylooligosaccharide for further preparation of a product which has better antioxidant property, is high in storage stability and meets special physiological needs of pregnant women in the gestation period. The compound product has the better antioxidant property, is high in storage stability, meets physiological characteristics of the pregnant women in the gestation period and needs of growth and development of fetuses, can promote fetal brain development, guarantee normal development of fetal organs, relieve constipation of the pregnant women in the gestation period, improve organism immunity of the pregnant women and reduce blood pressure, blood fat and blood sugar, and reduces incidence rate of diseases such as hypertension, diabetes mellitus and the like in the gestation period.
Owner:BIOLOGY INST OF SHANDONG ACAD OF SCI

Fetal brain age estimation and anomaly detection method and device based on deep learning

The invention discloses a fetal brain age estimation and anomaly detection method and device based on deep learning. The brain age estimation and anomaly detection method comprises the following steps: firstly, establishing a data set of T2 weighted magnetic resonance images of the brain of a normal fetus by utilizing T2 weighted images in the uterus of a pregnant woman, which are collected clinically and conventionally; secondly, segmenting the brain of the fetus from the uterus by using a U-shaped network, predicting the brain age of the fetus by using a deep residual network based on an attention mechanism, and generating the uncertainty of the brain age and the credibility of the estimation of the brain age of the fetus; and finally, constructing a classifier according to the difference, uncertainty, credibility and other indexes of the actual fetal age and the predicted brain age, and judging whether the brain development of the fetus is abnormal or not. According to the method, the brain age of the fetus can be estimated at the same time, indexes such as uncertainty and estimation credibility are generated to be used for detecting the fetus with abnormal brain development, and the method and device have high accuracy and precision and high clinical application prospect and value.
Owner:ZHEJIANG UNIV

Construction method of brain corpus callosum segmentation prediction image for corpus callosum state evaluation

The invention discloses a construction method of a brain corpus callosum segmentation prediction image for corpus callosum state evaluation, which comprises the following steps: drawing a corpus callosum initial contour line from an acquired fetal brain ultrasonic image, and calculating a key point offset of the corpus callosum initial contour line; and cutting a brain corpus callosum segmentation prediction image from the fetal brain ultrasound image according to the initial contour line of the corpus callosum and the key point offset. According to the deep neural network model for fetal ultrasound image state analysis, the blank of brain ultrasound image brain corpus callosum state analysis is filled, and a method for evaluating the brain corpus callosum state through a brain ultrasound image is created for the first time.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

System for detection and analysis of material uterine, material and fetal cardiac and fetal brain activity

The present invention presents a method and apparatus for recording and analyzing uterine electrical activity, or electromyography (EMG), from the surface of the abdomen, vagina, or cervix of a patient for the purpose of diagnosing contractile patterns of the uterus in pregnant and non-pregnant women. The method and apparatus described include methods for the systematic detection, analysis, characterization and communication of infomation about electrical signals recorded from the abdominal / vaginal / cervical surface. The present invention provides data analysis techniques for analyzing the electrical data measured from the surface of a patient to characterize their uterine, abdominal, and cardiac muscle activity, as well as cardiac and brain activity of the fetus simultaneously or separately. These techniques and apparatus are appropriate for use in a clinic or through landline or wireless communication for use as a remote or home uterine / fetal monitoring system.
Owner:REPRODIVE HEALTH TECH

Compound edible oil for pregnant women and preparation method thereof

The invention discloses the technical field of edible oil and specifically relates to compound edible oil for pregnant women and a preparation method thereof. Raw materials of the compound edible oilcomprise: camellia seed oil, refined sesame oil, walnut oil, purple perilla seed oil and a DHA emulsion. The camellia seed oil and purple perilla seed oil have a good regulating effect on the heart and cerebral vessels, digestion, reproduction, neuroendocrine and immune system of pregnant women, and effectively reduce the occurrence of hypertensive symptoms during pregnancy. Refined sesame oil isrich in vitamin E, and has a flavor-enhancing effect. Vomiting and loss of appetite are prone to occur for pregnant women in the early stage of pregnancy. Refined sesame oil makes the compound edibleoil for pregnant women taste delicious so as to effectively improve the appetite of pregnant women. Walnut oil and the DHA emulsion promote the development of fetal brain. The DHA emulsion is preparedfrom DHA algae oil as a raw material. With the addition of the emulsifier, stability of DHA algae oil is increased so as to increase stability of the compound edible oil for pregnant women and make the compound edible oil to be easily stored.
Owner:浙江健达农业开发有限公司

Method and system for imaging fetal brain channeling three-dimensional image in ultrasonic image

The invention discloses a method for imaging fetal brain channeling three-dimensional image in an ultrasonic image, which aims to quickly and visually evaluate the development condition of fetal brainchanneling by adopting an artificial intelligence method through three-dimensional volume data of fetal brain. The method comprises the following steps: obtaining a large amount of three-dimensionalultrasonic volume data of fetal brain; inputting volume data to an intelligent imaging processing system, and manually marking brain channeling so as to obtain fetal craniocerebral three-dimensional brain channeling volume image data; inputting the fetal craniocerebral three-dimensional brain channeling volume image data into a trained 3D FCN network to obtain voxels of a fetal craniocerebral three-dimensional brain channeling volume image; automatically reconstructing a fetal craniocerebral channeling three-dimensional image by using voxels of the fetal craniocerebral three-dimensional channeling volume image, and outputting the fetal craniocerebral channeling three-dimensional image. The method can solve the technical problems that an existing clinician cannot reconstruct a fetal brain channeling three-dimensional image, the reconstruction steps are complex, the reconstruction individual difference is large, an objective analysis basis is lacked, and the result repeatability is poor.
Owner:SHENZHEN MATERNITY & CHILD HEALTHCARE HOSPITAL

Three-dimensional ultrasound imaging method and device

A three-dimensional ultrasonic imaging method and a three-dimensional ultrasonic imaging device. The three-dimensional ultrasonic imaging method includes the following steps: transmitting ultrasonic waves to the fetal head; receiving ultrasonic echoes to obtain ultrasonic echo signals; obtaining a three-dimensional volume of the fetal head according to the ultrasonic echo signals. Data; according to the characteristics of the mid-sagittal section of the fetal head, the mid-sagittal section is detected from the three-dimensional volume data; the orientation of the fetal head in the mid-sagittal section is determined; according to the orientation of the fetal head, the mid-sagittal section Displayed as an image suitable for observation. The mid-sagittal section image is processed and displayed as an image conforming to human observation habits, which makes it easier for doctors to identify and observe the situation of the mid-sagittal section of the fetal brain.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD

Whey yak milk protein powder for postpartum women in confinement and preparation method thereof

The invention discloses whey yak milk protein powder for postpartum women in confinement and a preparation method thereof and belongs to the technical field of nutritious and health-care food. The whey yak milk protein powder can be used for women in pregnancy and postpartum confinement. A formula of the whey yak milk protein powder involves a large number of nutrient substances including proteins, vitamins, minerals and the like which are required by women in pregnancy and childbirth; lactoferrin can resist bacteria and viruses and regulate the absorption of iron by the gastrointestinal tract; folic acid can help the normal development of fetal brains and nervous systems and promote the formation of red blood cells; docosahexaenoic acid (DHA) can help children develop intelligence. The whey yak milk protein powder is a new product prepared from various high-quality nutrient components, has the advantages of being high in purity and absorption and utilization rate, free of toxic or side effects, convenient to take and remarkable in effect, and is particularly suitable for pregnant and lying-in women.
Owner:北京雪域圣肽生物科技有限公司

All-purpose nutrient biscuits suitable for early-pregnancy consumption

The invention provides all-purpose nutrient biscuits suitable for early-pregnancy consumption. The all-purpose nutrient biscuits suitable for early-pregnancy consumption are prepared from the following raw materials in parts by mass: 100 parts of milk powder for pregnant women, 20 parts of sweet milk powder, 50 parts of wheat flour, 50 parts of eggs, and water. The formulated milk powder for the pregnant women is rich in proteins, vitamins, minerals, DHA and other essential fatty acids, as well as appropriate in calcium-phosphorus ratio, so that calcium absorption is facilitated; the DHA is anessential fatty acid which is capable of promoting development of fetal brain and nervous system; and the sweet milk powder is capable of adjusting taste of the biscuits so as to increase appetite. Thus, the prepared all-purpose nutrient biscuits suitable for early-pregnancy consumption are rich in nutrients, higher in content of proteins, vitamin A, vitamin B and minerals compared with common biscuits, and enriched with essential fatty acids such as the DHA. The biscuits provide nutrients and energy to pregnant women, and are simple in production processes and common in raw material source;finished products of the biscuits are convenient to carry, crispy in taste and unique in milk aroma, so that the biscuits can be accepted by the pregnant women during early pregnancy. Moreover, the biscuits are beneficial for relieving vomiting during pregnancy, as well as capable of improving nutritional status of the pregnant women and fetuses; and thus, the biscuits are suitable as an extra-meal food for the pregnant women.
Owner:SHANDONG SHANDA HOSPITAL FOR REPRODIVE MEDICINE

Quick fetal MR image brain extraction method based on multi-scale neural network

The invention discloses a quick fetal MR image brain extraction method based on a multi-scale neural network, and belongs to the technical field of medical images. The method comprises the following steps: carrying out the multi-scale learning of fetal MR image features; fusing the fetal MR image multi-scale features by using a channel attention model; performing brain extraction on the fetal MR image based on the multi-scale features; according to the method, the MR image containing the fetal brain is quickly extracted by using the full convolutional network, and the extracted multi-scale features are fused by using a channel attention mode, so that an accurate fetal brain extraction result is obtained.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

Method and device for fetal brain age estimation and abnormal detection based on deep learning

The invention discloses a method and device for estimating fetal brain age and abnormality detection based on deep learning. In the method of brain age estimation and abnormality detection, firstly, a data set of normal fetal brain T2-weighted magnetic resonance images is established by using T2-weighted images of pregnant women collected routinely in clinic. Secondly, the U-shaped network is used to segment the fetal brain from the uterus, and then the deep residual network based on the attention mechanism is used to predict the fetal brain age, and the uncertainty of the brain age and the reliability of the fetal brain age estimation are generated. Finally, a classifier is constructed based on the differences between actual gestational age and predicted brain age, uncertainty, and reliability to determine whether fetal brain development is abnormal. The present invention can estimate the age of the fetal brain at the same time, and generate indicators such as uncertainty and estimation reliability to detect fetuses with abnormal brain development, and has high accuracy and precision as well as high clinical application prospects and value .
Owner:ZHEJIANG UNIV

Treatments and prevention of opioid neonatal abstinence syndrome

Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves administering to the pregnant subject a composition comprising an opioid antagonist in an amount effective to reduce or prevent fetal opioid dependence, wherein the opioid antagonist a) is orally available or delivered systemically and reaches the circulation of the pregnant subject, b) is substantially excluded from the subject's brain by the blood brain barrier, and c) penetrates the placenta and enters the fetal brain. The method also includesadministering the opioid antagonist to the neonate in increasing amounts to facilitate weaning the neonate from continued opioid maintenance.
Owner:OHIO STATE INNOVATION FOUND

Formula milk powder containing arachidonic acid for pregnant and parturient women and preparation method thereof

ActiveCN102488011BGood for brain and optic nerve developmentImprove the deficiency of essential fatty acidsMilk preparationVegetable oilPhysiology
The invention relates to formula milk powder containing arachidonic acid for pregnant and parturient women and a preparation method thereof. The formula milk powder is composed of the following components in percentage by weight: 40-50% of skimmed milk, 10-14% of desalinated whey, 8-12% of carbohydrate, 8-12% of milk protein, 6-10% of white granulated sugar, 4-7% of vegetable oil, 3-6% of fructooligosaccharides, 0.5-1% of mineral matter, 0.5-1% of water-soluble vitamin premix, 0.5-1% of soybean phosphatide, 0.5-1% of essence, 0.3-0.6% of docosahexaenoic acid, 0.1-1% of arachidonic acid, less than 0.1% of taurine and 0.01-0.04% of fat-soluble vitamin premix. According to the invention, the formula milk powder is richer in nutrition, is favorable for the development of the fetal brain and optic nerve, and can improve the phenomenon of essential fatty acid deficiency caused by pregnancy and lactation of mothers.
Owner:AUSNUTRIA DAIRY CHINA

Secreted neural apoptosis inhibiting proteins

A novel neuroprotectant was identified by microarray analysis that is differentially expressed between the ventricular zone and the cortex of human adult and fetal brain. The secreted protein antagonizes Wnt action in Xenopus embryos. Methods are described for modulating free radical neurotoxicity by contacting cells with the protein, treating neuronal diseases associated with free radical-mediated cell death by administering the protein, determining neuroprotective genomic targets associated with select free radical toxicity pathways by screening with the protein and using the protein to identify other compounds that modulate the biological activity of the secreted protein and the cell machinery that reacts to the secreted protein.
Owner:AVENTIS PHARMA INC

Method for building hiPSCs source autism-like model

PendingCN111254107AEliminate the disadvantages of cultivating oversimplifiedInfluence favors direct observationNervous system cellsArtificial cell constructsMedicineMedicinal chemistry
The invention relates to a method for building an hiPSCs source autism-like model. The method mainly comprises the steps of (1) preparing a micro-column array chip; (2) inducing a brain organoid on the chip; and (3) performing VPA treatment on a 3D brain organoid in the early period of the induction stage. According to the method, stem cells and tissue engineering are mainly combined to generate 3D brain organoid tissues; and VPA (sodium valproate) conforming to the physiological concentration is applied to simulate the influence on fetal brain development after VPA is taken by a pregnant woman with bidirectional affective disorder or epilepsy, so that a pathological mechanism of occurrence of autism is explored. The model is a novel autism in vitro model; the morphological changes of theVPA on the fetal brain development can be observed; and meanwhile, the pathogenic mechanism of the VPA increasing the fetal autism risk is explored by various measures of molecular biology and the like. Therefore, the species difference caused by animal experiments, the simplicity of cell experiments and the defects of 2D conditions can be eliminated, and a novel model and thought are provided forexploring the occurrence of autism.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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