47results about How to "Increase and decrease level" patented technology

Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating a wound to a surface tissue or a symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

This invention provides a method for obtaining a gene involved in regulation of cartilage differentiation, in which a transcription factor, preferably Runx2/Cbfa1, is forcedly expressed in a cell that is deficient such transcription factor, preferably in a Runx2/Cbfa1-deficient chondrocyte, and the gene, the expression of which is thereby induced, is selected using DNA chip analysis, subtraction, or other means as well as a Runx2/Cbfa1-deficient chondrocyte useful for carrying out such method. The invention also provides a polynucleotide obtained by such method, a polypeptide encoded by such polynucleotide, an antibody against such polypeptide, a recombinant vector comprising such polynucleotide, a transformant comprising such recombinant DNA vector, a cell expressing such polypeptide, a transgenic animal of such polynucleotide, an animal model of a bone and/or joint disease (preferably osteoarthritis), a method for screening for a therapeutic agent and/or prophylactic agent for a bone and/or joint disease (preferably osteoarthritis) using the aforementioned objects, a candidate compound for a therapeutic agent and/or prophylactic agent selected by such method, a pharmaceutical composition for a bone and/or joint disease (preferably osteoarthritis), and a method for diagnosing such disease.

The present invention provides polynucleotides and related polypeptides of the class of genes involved in maize secondary wall (ZmSCW) formation. The invention provides genomic sequence for the ZmSCW genes. ZmSCW are responsible for controlling plant growth, secondary cell wall development and yield in crop plants.

A microphone and a method for operating a Microphone are disclosed. In an embodiment the microphone includes a transducer and a mode controller. The microphone has a normal operating mode (M_O) and a collapse mode (M₁). The mode controller switches to the collapse mode (M₁) when an output signal of the transducer reaches or exceeds a predefined threshold value and switches to the normal operating mode (M_O) when the output signal reaches or falls below a predefined further threshold value (S₁).

The invention relates to an electromagnetic radiation absorber for a preselected frequency range, comprising:

• • an absorbent sheet (10) located such that said electromagnetic radiation falls on it, and
  • a conductive base (20) located under said absorbent sheet, wherein said absorbent sheet:
  • has a total thickness e exceeding λ/(ε)^1/24, where λ is the wavelength of the incident electromagnetic radiation, and
  • is made up of a dielectric material containing amorphous magnetic microwires, the magnetic permeability of which in the preselected frequency range has an imaginary part μ″ which is at least 100 times greater than the corresponding real part μ′, said microwires being distributed in a volume having a thickness e₂ of at least λ/(ε)^1/216, where ε is the dielectric constant of the absorbent sheet and said volume is located a distance e₃ from the conductive base that is not less than λ(ε)^1/28.

The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosme (5hmC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.

The present invention relates to the use of molecular risk marker profiles for diagnosis of Parkinson's disease. More particularly, the invention provides methods for diagnosis of Parkinson's disease in an individual, utilizing certain profiles established based on the expression levels of certain genes, which together form a gene panel, in the peripheral blood of said individual, as well as kits for carrying out these methods. The profile encompass ALDH1A1.

Systems and methods are provided for dynamically allocating and accessing hosting server resources to users of hosting services. The system may include one or more servers that provide multiple levels of access to the hosting server resources, and an administration server configured with one or more migration paths that allow the user to migrate the account between two levels while the account remains accessible to all entities authorized to access the account. The hosting server resources may be divided according to virtual partitions that are resizable by the administration server. The system may include a migration interface stored on and accessible to the user from the administration server. The migration interface provides the user with options to migrate the account between the levels of access. The system may include an application programming interface that provides access to the administration server for changing the account's level of access.

The present application affords control over tyrosine bonding in a variety of applications through the use of peroxidase enzymes, preferably wheat peroxidase 1, free radical scavengers, polyhydric alcohols, and protease. Methods of the present invention find utility in the bonding of polymers and proteins and are especially useful in the baking industry wherein the present invention will assist in consistently producing products of optimum quality.

The present disclosure relates to the identification of genes and gene combinations that are correlated with patients having or being predisposed to developing pancreatic ductal adenocarcinoma (PDAC). In some instances, methods herein utilize panels of 5 or 10 genes to accurately diagnose PDAC, determine the likelihood of developing PDAC, or determine the severity/stages of PDAC. These panels may be used in a molecular diagnostic test.

The present invention concerns a method for modifying the growth characteristics of plants by modulating expression in a plant of a nucleic acid sequence encoding a metallothionein and/or modulating activity in a plant of a metallothionein. The invention also relates to transgenic plants having modified growth characteristics, which plants have modulated expression of a nucleic acid encoding a metallothionein.

A method for improving the yield of a plant is presented. The method uses genetic engineering techniques for transformation of plants to introduce expression cassettes for over- or under-expression of genes involved in photoperiodic control of floret differentiation and degradation. Such methods provide for increased yield at harvest when compared to wild-type plants.

A system for controlling access to hosted services using computer generated question answer sets is described. The question answer sets are generated and include relationships which are designed to distinguish between human and automated system interpretation through the inclusion of a dynamically established transformation of characteristics in relation to objects described in the question answer sets. The dynamically established transformation provides an additional defense against malicious neural networks used to overcome mechanisms for distinguishing between humans and automated systems. Corresponding methods and devices are contemplated. In an additional embodiment, a decoy set of answer sets are also established to maintain a blacklisted set of suspected automated systems.

The invention is directed to a use of a polymer composition comprising an ethylene polymer for producing a crosslinked pipe, a process for producing a crosslinked pipe and to a crosslinked pipe comprising a crosslinked polymer composition which comprises a crosslinked ethylene polymer.

This invention provides means for altering the harvest index of crop plants by modulating the expression of transgenic genes using dimerization domain and component stacks, thereby modulating plant architecture. The transgene/dimerization domain stacks are provided in a single transformation vector unit and are used to modulate plant growth, yield, and harvest index in plants.