Tissue-specific wound dressing as well as preparation method and application thereof

Abstract

The invention relates to the technical field of wound dressings, in particular to a tissue-specific wound dressing as well as a preparation method and application thereof. The tissue-specific wound dressing comprises an extracellular matrix extracted from tissue and a gelling material, wherein the tissue is an organ or an animal organ or tissue corresponding to the organ or tissue to which the dressing is applied, and the gelling material can crosslink and cure the extracellular matrix, so that the extracellular matrix has high adhesion to wet tissue and can be quickly adhered to a wound to stop bleeding. According to the tissue-specific wound dressing, the extracellular matrix and the gelling material are matched, so that compared with a common wound dressing, the tissue-specific wound dressing can shorten wound healing and tissue repairing time remarkably, has good hemostatic and wound healing effects, and can be used for massive hemorrhage or visceral hemorrhage. The tissue-specificwound dressing fills the blank that the extracellular matrix is used as a wound dressing.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a tissue-specific wound dressing and its preparation method and application. Background technique [0002] Wound dressings are articles for dressing wounds, materials used to cover acne, wounds or other damages. The types of wound dressings include: passive dressings (traditional dressings), which passively cover the wound and absorb exudate, providing limited protection for the wound; interactive dressings, where there are various forms of interaction between the dressing and the wound, Such as absorbing exudate and toxic substances, allowing gas exchange, thereby creating an ideal environment for healing; barrier outer structure, preventing microbial invasion in the environment, preventing cross-infection of wounds, etc.; bioactive dressings (occlusive dressings). [0003] At present, there are the following problems in the application of wound dressings: the main repa...

AI Technical Summary

Problems solved by technology

[0003] At present, there are the following problems in the application of wound dressings: the main repairing material in the dressing is non-natural extracellular matrix components. After dressing, cells need to undergo cell migration and degradation to gradually generate extracellular matrix components. The process is relatively long. For The effect of hemostasis is relatively poor, and it is difficult to be used for bleeding and wet tissue adhesion hemostasis

However, the wrong secretion of extracellular matrix (for example, myofibroblasts secrete a large amount of collagen-rich extracellular matrix at the wound site) often leads to changes in tissue mechanics and mechanical properties, scar formation, and ultimately loss of tissue functionality

[0005] There is no report on the application of acellular extracellular matrix in wound repair and wound hemostasis in the prior art. The main problem is that although natural extracellular matrix materials can guide wound repair well, their mechanical strength is low, making it difficult to quickly and effectively Adhesive to the wound, unable to achieve a good hemostasis and wound healing effect, poor adhesion to wet tissue, difficult to use for bleeding or visceral bleeding

It is difficult to achieve such an effect with pure extracellular matrix

[0006] In the patent with the publication number CN201510447495.7, a chitosan-extracellular matrix tissue repair membrane and its preparation method are disclosed, which mixes chitosan and extracellular matrix tissue and applies it to the tissue repair membrane, which uses the shell Glycan and extracellular matrix are pre-mixed to form a film, which is only suitable for the slow repair of tissue damage, and cannot be used for hemostasis and repair of acute wounds

Images