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Polycinnamic alcohol injection and its prepn

A technology of injection preparation and lauryl alcohol, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as deep ulcers, insignificant elimination of varicose veins, etc. The effect of ensuring product quality

Active Publication Date: 2006-03-01
SHAANXI TIANYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] SM has been used to treat esophageal variceal bleeding for many years, but it is rarely used in foreign countries because of side effects such as chest pain, deep ulcer, and fever after injection of SM, which are higher than other sclerosing agents, and there are also reports that the varicose veins are not obviously eliminated.

Method used

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  • Polycinnamic alcohol injection and its prepn

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Embodiment Construction

[0025] In the process of preparing lauromacrogol injection, the lauromacrogol injection prepared is:

[0026] Generic name of the drug: lauromacrogol injection

[0027] English name: Lauromacrogol Injection

[0028] Previously used names: Ethoxysclerotin Injection, Polydocanol Injection

[0029] Main ingredients of this product: Lauromacrogol

[0030] Chemical name: polyoxyethylene lauryl ether

[0031] Molecular formula: C 12 h 25 (OCH 2 CH 2 )n0H(n=9)

[0032] Molecular weight: 582.8

[0033] 1. Lauromacrogol injection prescription and preparation method:

[0034] ① Prescription:

[0035] Lauromacrogol 1g

[0036] Ethanol 5ml

[0037] Add water for injection to 100ml

[0038] ②Key points of detailed process operation:

[0039] Add 1g of lauromacrogol to the alcohol container, then add 5ml of ethanol, stir to dissolve the lauromacrogol completely, then add water for injection to 100ml; Add 0.05-0.3% activated carbon for needles, heat to boil with steam, and the...

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Abstract

The present invention relates to one kind of polycinnamic alcohol injection and its preparation. The polycinnamic alcohol injection is used mainly in treating esophagus varication hemorrhage and esophagus varication cirrhosis under endoscope. The polycinnamic alcohol injection contains in each 100 ml polycinnamic alcohol 1 g and alcohol 5 ml. Alcohol can dissolve polycinnamic alcohol easily and has slight narcosis, so that the polycinnamic alcohol injection has no pain caused, low viscosity for easy injecting, no side effect and less complication.

Description

1. Technical field: [0001] The invention relates to a lauromacrogol injection and a preparation method thereof. 2. Background technology: [0002] Currently, liver disease ranks second in the mortality rate of malignant diseases, with at least 300,000 newly discovered patients and 110,000 liver disease patients dying each year. There are no less than 3 million patients with liver cancer and severe liver cirrhosis in the country, and about one-third of patients will develop esophageal varices; there are about 250,000 patients with esophageal varices, which are caused by gastric cancer, esophageal cancer and portal hypertension. There are about 300,000 people with gastrointestinal bleeding, and about 500,000 patients with gastric bleeding caused by other reasons. [0003] In response to the rapid increase in the incidence of gastrointestinal hemorrhage, hospitals in various provinces, municipalities, and autonomous regions across the country have been exploring to find more e...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61K9/08A61P1/16
Inventor 杨军营
Owner SHAANXI TIANYU PHARMA
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