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Method for preparing squalene based on tobacco as raw material

A technology of squalene and tobacco, applied in the chemical field, achieves the effect of convenient operation, high promotion value, and prolonging the industrial chain of the tobacco industry

Inactive Publication Date: 2011-08-24
GUANGDONG BRANCH OF CHINA TOBACCO GENERAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to fill up the technical deficiency of existing squalene preparation technology and tobacco waste recycling technology, provide a new method for preparing squalene, extract squalene from the resource of tobacco waste, to meet Market demand for squalene, especially the new demand for squalene in the field of cigarette production, and at the same time solve the problem of waste disposal of tobacco dust waste in tobacco companies

Method used

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  • Method for preparing squalene based on tobacco as raw material
  • Method for preparing squalene based on tobacco as raw material
  • Method for preparing squalene based on tobacco as raw material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] After the tobacco waste in the cigarette production workshop is dried, it is pulverized with a pulverizer and passed through a 60-mesh sieve, and the unsifted tobacco leaves are pulverized by the pulverizer until all of them pass through the 60-mesh sieve.

[0035] Take 100g of tobacco waste dry powder passed through a 60-mesh sieve into a 1000mL conical flask, add 300mL of ethyl formate and 60mL of distilled water, use the cold soaking method, shake once every 1h, extract at room temperature for 8h, filter, collect the filtrate, and filter the residue again Add 300 mL of ethyl formate and 60 mL of distilled water to extract again, repeat this 3 times, combine the 3 extraction filtrates, separate the layers of the filtrate with a separatory funnel, collect the ethyl formate layer, and distill off the solvent under reduced pressure to obtain squalene-containing The crude extract 3.7g, after testing the squalene content is 45%.

[0036] Take 1g of squalene crude extract a...

Embodiment 2

[0038] Take 100g of tobacco waste dry powder passed through a 60-mesh sieve into a 1000mL conical flask, add 288mL of ethyl formate and 72mL of distilled water, use the cold soaking method, shake once every 1h, extract at room temperature for 8h, filter, collect the filtrate, and filter the residue again Add 288mL of ethyl formate and 72mL of distilled water to extract again, repeat this 3 times, combine the 3 extraction filtrates, separate the layers of the filtrate with a separatory funnel, collect the ethyl formate layer, and distill off the solvent under reduced pressure to obtain squalene-containing The crude extract is 3.3g, and the squalene content is 35% after testing.

[0039] Take 1g of squalene crude extract and add it to silica gel chromatography (22×200mm) with 20g of silica gel, elute with petroleum ether (30-60°C), collect the colorless part of the washing solution, and remove it by vacuum distillation Petroleum ether, that is, 0.35g of squalene fine product, co...

Embodiment 3

[0041] Take 100g of tobacco waste dry powder crushed through a 60-mesh sieve into a 1000mL conical flask, add 300mL of petroleum ether (60-90°C) and 50mL of distilled water, use cold soaking method, shake once every 1h, extract at room temperature for 10h, filter, Collect the filtrate, add 300mL petroleum ether (60-90℃) and 50mL distilled water to extract the filter residue again, repeat this 3 times, combine the 3 extraction filtrates, separate the layers of the filtrate with a separatory funnel, collect the petroleum ether layer, and distill under reduced pressure Remove solvent, obtain the crude extract 4.0g that contains squalene, after testing squalene content is 40.9%.

[0042] Take 1g of the crude extract and add it to silica gel chromatography (22×200mm) equipped with 20g of silica gel, elute with n-hexane, collect the colorless part of the eluate, remove n-hexane by vacuum distillation, and obtain the fine squalene 0.38g, containing 98% squalene after testing.

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Abstract

The invention provides a method for preparing squalene based on tobacco as a raw material. The method comprises the following steps: smashing dried tobacco leaves, leaching out fat-soluble substances with an organic solvent, and removing the organic solvent in the fat-soluble substances so as to obtain crude tobacco squalene; passing the crude tobacco squalene through a silica gel chromatograohiccolumn, eluting with the organic solvent, collecting eluent, and removing the organic solvent by using a decomposition distillation method so as to obtain the fine squalene. The content of the squalene in the crude squalene is more than 35%, the content of the squalene in the fine squalene is more than 95%. Tobacco resources are abundant and can meet industrial requirement; in the method, waste tobacco and cigarette fine waste in the cigarette production can be fully utilized to prepare the squalene; and according to the invention, a technical basis is provided for development and utilizationof the tobacco squalene, especially for the application of the tobacco squalene in the aspect of cigarette production. Thus, the social benefits and economic benefits are great.

Description

technical field [0001] The invention belongs to the technical field of chemistry, and in particular relates to a method for preparing high-purity squalene from tobacco. Background technique [0002] Squalene is a lipid unsaponifiable substance, a polyunsaturated olefin (tricosahexaene), originally discovered from shark liver oil, named Squalene in 1914, and its chemical name is 2, 6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, which is an open-chain triterpene, also known as cod liver oil terpene, participates in the synthesis of cholesterol in the human body and can It promotes metabolism, has many physiological functions such as increasing the activity of superoxide dismutase (SOD) in the body, enhancing the body's immunity, anti-aging, anti-fatigue, anti-tumor, etc. It is a non-toxic marine organism with the effect of preventing and curing diseases active substance. [0003] Squalene widely exists in animals and plants. Among animals, the liver of deep-sea ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C11/21C07C7/12A24B15/18
Inventor 陈泽鹏江定心罗福命李茂军陈伟明王军张丹丹万树青
Owner GUANGDONG BRANCH OF CHINA TOBACCO GENERAL
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