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Composition for restoring skin barrier and preparation method and application thereof

A technology for repairing skin and composition, applied in the field of cosmetics, can solve problems such as insufficient attention to skin barrier correlation and lack of skin barrier, improve skin immunity and tolerance, facilitate popularization and application, and achieve remarkable efficacy Effect

Active Publication Date: 2018-09-14
广东卓明仕生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing cosmetics on the market for repairing the skin barrier mainly improve the moisture and barrier function of the skin by simulating real skin keratin lipids. Although they have certain effects, they cannot fundamentally solve the problem of skin barrier loss
[0004] The barrier function of the skin is closely related to the tolerance of the skin. The enhancement of skin immunity helps to improve the tolerance of the skin. Numerous cells in the skin play an important role in the immune response. Langerhans cells are tree A part of dendritic cell is an important immune cell in the epidermis, which has the function of antigen presentation, but its correlation with the skin barrier has not received enough attention

Method used

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  • Composition for restoring skin barrier and preparation method and application thereof
  • Composition for restoring skin barrier and preparation method and application thereof
  • Composition for restoring skin barrier and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 A kind of composition (I) for repairing skin barrier

[0026] A composition for repairing the skin barrier, comprising the following components in parts by weight: moisturizing agent 55, β-glucan 15, ceramide 10, wild soybean seed extract 3, Polygonum cuspidatum root extract 5, transparent Bone grass extract 5, amino acid 4, acetyl hexapeptide-8 1, carnosine 1, dipotassium glycyrrhizinate 0.5, sodium hyaluronate 0.5, and other appropriate adjuvants such as p-hydroxyacetophenone, 1,2- Hexylene glycol, ethylhexylglycerin, etc.

[0027] The moisturizing agent is a composition of glycerin, 1,3-propanediol and butanediol, and its weight ratio is 1:1:1.

[0028] The amino acid is a composition of glutamic acid, glycine, arginine, alanine, aspartic acid, leucine and serine, and its weight ratio is 6:6:4:3:2:2:1.

[0029] The sodium hyaluronate includes macromolecular sodium hyaluronate and small molecular sodium hyaluronate, the molecular weight of the macromole...

Embodiment 2

[0034] Example 2 A composition (II) for repairing the skin barrier

[0035] A composition for repairing the skin barrier, made of the following components in parts by weight: moisturizing agent 55, β-glucan 15, ceramide 12, wild soybean seed extract 4, knotweed root extract 4 , Scutellaria extract 4, amino acid 3, acetyl hexapeptide-8 1, carnosine 1, dipotassium glycyrrhizinate 0.5, sodium hyaluronate 0.5, and other appropriate adjuvants such as p-hydroxyacetophenone, 1, 2-hexanediol, ethylhexylglycerin, etc.

[0036] The moisturizing agent is a composition of glycerin, 1,3-propanediol and dipropylene glycol, and its weight ratio is 2:2:1.

[0037] The amino acid is a composition of glutamic acid, glycine, arginine, alanine and lysine, and its weight ratio is 10:5:3:3:1.

[0038] The sodium hyaluronate includes macromolecular sodium hyaluronate and small molecular sodium hyaluronate, the molecular weight of the macromolecular sodium hyaluronate is in the range of 1,000,000 D...

Embodiment 3

[0041] Example 3 A composition (Ⅲ) for repairing the skin barrier

[0042] A composition for repairing the skin barrier, made of the following components in parts by weight: moisturizing agent 50, β-glucan 20, ceramide 10, wild soybean seed extract 3, Polygonum cuspidatum root extract 5 , Scutellaria extract 5, amino acid 2, acetyl hexapeptide-8 2, carnosine 2, dipotassium glycyrrhizinate 0.8, sodium hyaluronate 0.2, and other appropriate adjuvants such as p-hydroxyacetophenone, 1, 2-hexanediol, ethylhexylglycerin, etc.

[0043] The moisturizing agent is a composition of glycerin, butanediol and 1,2-hexanediol, and its weight ratio is 20:30:1.

[0044] The amino acid is a composition of glutamic acid, leucine, alanine and serine, and its weight ratio is 10:4:2:1.

[0045] The sodium hyaluronate includes macromolecular sodium hyaluronate and small molecular sodium hyaluronate, the molecular weight of the macromolecular sodium hyaluronate is in the range of 1,000,000 Da to 2,0...

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Abstract

The invention provides a composition for restoring a skin barrier and application thereof. The composition is prepared from, by weight, 20-80 parts of wetting agent, 5-30 parts of beta-glucan, 1-15 parts of ceramide, 1-10 parts of wild groundnut seed extract, 1-10 parts of polygonum cuspidatum root extract, 1-10 parts of garden balsam stem extract, 0.5-5 parts of amino acid, 0.1-3 parts of acetylhexapeptide, 0.1-3 parts of carnosine, 0.1-1 part of dipotassium glycyrrhizinate and 0.05-1 part of sodium hyaluronate. It is proved through experiments that all the components of the composition forrestoring the skin barrier achieve a remarkable synergistic effect, synthesis of intercellular lipid of the skin can be effectively promoted, the damaged skin is restored, and the skin barrier is rebuilt. The function of improving skin immunity and tolerance is achieved on the skin in a sub-health status and the skin which just restores to be normal; the effects of replenishing and keeping moisture, smoothening wrinkles and improving gloss are achieved on the healthy skin.

Description

technical field [0001] The invention relates to the field of cosmetics, and mainly relates to a composition for repairing skin barrier and its application. Background technique [0002] The skin is the first physiological barrier of the human body. A healthy skin barrier can resist external harmful substances, irritants and sunlight, and also has moisturizing and regulating functions. However, due to factors such as environment, diet and wrong skin care, the skin barrier is easily damaged, which makes the skin's own defense ability insufficient, leading to skin problems such as skin sensitivity, aging, dryness, and desquamation. [0003] The skin barrier function is closely related to its lipids. The lipids on the skin surface can be divided into sebaceous gland lipids and intercellular lipids according to their sources and components. Lamellar body is a special organelle formed in epidermal spinous cells. It is closely related to the formation of intercellular lipids. It c...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61K8/68A61K8/64A61K8/44A61K8/63A61Q19/00A61Q19/08
CPCA61K8/44A61K8/63A61K8/64A61K8/68A61K8/73A61K8/735A61K8/9789A61K2800/82A61Q19/00A61Q19/08
Inventor 陈庆生朱灿黄倩龚盛昭毛昭庆
Owner 广东卓明仕生物科技有限公司
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