Glycyrrhizic acid, biogastrone acid or its salt, derivative temperature sensing gel rubber, preparation method and application thereof

A technology of glycyrrhetinic acid salt and glycyrrhetinic acid, which is applied in the direction of drug combination, drug delivery, and medical preparations of non-active ingredients, etc., which can solve the problems of difficulty in achieving the desired therapeutic effect, short residence time of water preparations, and inconvenience in administration, etc. question

Inactive Publication Date: 2008-10-29
WUHAN WORLDNER UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used drug preparations for local mucosal administration are water and gel, but the water is difficult to achieve the desired therapeutic effect due to the short local residence time, and the drug waste is huge; and the gel is too thick, making the extremely inconvenient to administer

Method used

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  • Glycyrrhizic acid, biogastrone acid or its salt, derivative temperature sensing gel rubber, preparation method and application thereof
  • Glycyrrhizic acid, biogastrone acid or its salt, derivative temperature sensing gel rubber, preparation method and application thereof
  • Glycyrrhizic acid, biogastrone acid or its salt, derivative temperature sensing gel rubber, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024]Embodiment 1: according to the weight percent example of 0.5% poloxamer, 10% carboxymethyl chitosan, 0.001% glycyrrhizic acid and surplus water, the poloxamer is added with water and stirred evenly, and carboxymethyl chitosan is added Chitosan is stirred evenly, and after defoaming, glycyrrhizic acid is added into the gel, stirred to disperse and dissolve, hot-pressed to sterilize, filled and sealed to obtain a temperature-sensitive gel. The gelling temperature of the gel is 35.5° C., and the gelling time is 5 minutes. (pH7.4 value)

Embodiment 2

[0025] Embodiment 2: according to the weight percent example of 30% poloxamer, 0.2% carboxymethyl chitosan, 8% sodium glycyrrhizinate and surplus water, the poloxamer is added with water and stirred evenly, and carboxymethyl chitosan is added base chitosan, stir evenly, after defoaming, add sodium glycyrrhizinate into the gel, stir to disperse and dissolve, heat-press sterilize, fill and seal to obtain the temperature-sensitive gel. The gelling temperature of the gel is 35° C., and the gelling time is 5 minutes. (pH 8.0)

Embodiment 3

[0026] Embodiment 3: by the weight percentage example of the poloxamer 407 of 20wt%, the poloxamer 188 of 17wt%, the carboxymethyl chitosan of 2%, the triammonium glycyrrhizinate of 1% and surplus water, will Poloxamer is added with water and stirred evenly, carboxymethyl chitosan is added, stirred evenly, after defoaming, triammonium glycyrrhizinate is added into the gel, stirred to disperse and dissolve, sterilized by hot pressing, filled and sealed to obtain a temperature-sensitive gel. The gelling temperature of the gel is 32° C., and the gelling time is 1 min. (pH8.0 value)

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Abstract

The invention relates to glycyrrhizic acid, glycyrrhetinic acid or glycyrrhetate, or derivative thermosensitive gel thereof, including 10-40 percent of poloxamer, 0.1-10 percent of carboxymethyl chitosan, 0.0001-10 percent of the glycyrrhizic acid, the glycyrrhetinic acid, the glycyrrhetate, the glycyrrhetinic acid salt or the derivative of the glycyrrhetinic acid, and 40-90.9 percent of water. The preparation method is as follows: the poloxamer is stirred evenly by adding water, the carboxymethyl chitosan is added to be stirred evenly as well, after the defoaming, the gel is added into the mixture until scattered and dissolved by stirring, and then the thermosensitive gel can be obtained by high-pressure sterilizing, filling and sealing; the medicine is the glycyrrhizic acid, the glycyrrhetinic acid, the glycyrrhetate and the glycyrrhetinic acid salt or the derivative of the glycyrrhetinic acid thereof. The invention can be used as a mucosa dosage preparation and an injection dosage preparation and can treat inflammatory bowel disease, stomatitis, oral ulcer, ocular inflammation and intracoelomic inflammations. The invention is convenient for clinical application, which can reduce the frequency of drug administration, improve the patient compliance, enhance the effectiveness of treatment and reduce toxicity and side effects.

Description

technical field [0001] The present invention relates to thermosensitive gel and its preparation method and application, more specifically to glycyrrhizic acid or glycyrrhetinic acid or its salt or its derivative thermosensitive gel and its preparation and medical application. Background technique [0002] The roots and rhizomes of licorice contain triterpenoid saponin Glycyrrhizic acid (Glycyr-rhi zicacid), that is, glycyrrhizin (Glycyrrhizin), which is the diglucuronide of glycyrrhetinic acid (Glycyrrhetinic acid, Glycyrrhetic acid). The chemical structure and molecular formula are as follows: [0003] [0004] Glycyrrhizic acid Molecular formula C 42 h 62 o 16 . [0005] [0006] Glycyrrhetinic acid Molecular formula C 30 h 46 o 4 [0007] Glycyrrhizic acid and glycyrrhetinic acid have anti-inflammatory and anti-ulcer effects. Our study also found that glycyrrhizic acid and glycyrrhetinic acid have obvious curative effects on inflammatory bowel disease (IBD),...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/704A61K31/56A61K47/34A61K47/38A61P1/00A61P29/00A61K47/10A61K47/36
Inventor 丁虹陈竹
Owner WUHAN WORLDNER UNITED PHARMA
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