49results about How to "Prevent excretion" patented technology

This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardiovascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.

The present invention relates to a preparation method and an application of a hyaluronic acid-antitumor drug conjugate and composite nanoparticle composition with characteristics of active targeting antitumor effect and biodegradability. The preparation method is characterized by comprising: (1) a synthesis method for conjugating an antitumor drug and a spacer and conjugating a targeting ligand hyaluronic acid or an ammonium salt thereof and the antitumor drug-spacer; and (2) a new technology for assembling the hyaluronic acid-antitumor drug conjugate and amphiphilic polyester block copolymer composite nanoparticles. The composition has effects of substantially increased drug loading, efficacy improving, in vivo long-circulating effect achievement, active tumor targeting property and drug toxic-side effect reduction. The macromolecular conjugate and complex nanoparticle composition can be used for injection administration, oral administration or mucosal administration. In addition, the preparation method has characteristics of mature process and high yield, and is suitable for industrial production.

An absorptive product comprising a front part, a rear part, an inside leg part, a waist opening, a pair of leg circumference openings, and a liquid-impermeable back sheet, wherein disposed on the inner side of the back sheet are a urinal front absorber and a feces rear absorber, with a take-out port formed for taking out these absorbers.

The invention relates to a nanomicelle of magnetic tumor double-targeting polymer and a preparation method thereof. The nanomicelle of magnetic tumor double-targeting polymer is a nuclear shell structure; the surface of an outer shell is connected with targeted ligand, an inner core is enclosed with nano-particles of super paramagnetic ferriferrous oxide and anticarcinogen with hydrophobic property; in virtue of the physical effect of an external magnetic field and induction of the targeting ligand, the tumor double-targeting function of the nanomicelle is realized. The invention also provides the preparation method of the nanomicelle of magnetic tumor double-targeting polymer: polyethylene glycol with end capping by folacin, and poly Epsilon-caprolactone or sandwich copolymer of poly propiolactone are taken as raw materials and enclosed with the nano-particles of super paramagnetic ferriferrous oxide and the anticarcinogen with hydrophobic property, and then dialysed to obtain the nanomicelle of magnetic tumor double-targeting polymer. The drug carrier system of the nanomicelle reinforces the treatment effect of the anticarcinogen with hydrophobic property on tumor, prolongs the circulating time of the anticarcinogen in human body, intensifies the targeting action of drugs, improves the release efficiency and partial concentration of drugs, and reduces the dosage and toxic and side effect of drugs.

The invention belongs to the fields of polymer chemistry and medicinal preparations, and particularly relates to a method for synthesizing an active targeted hyaluronic acid-polylactic acid carrier, a method for preparing an anti-tumor medicinal micelle of the active targeted hyaluronic acid-polylactic acid carrier and an application thereof. By adopting a novel self-assembly technology, amphipathic PEG (polyethylene glycol) block polyester copolymer and tumor targeted ligand hyaluronic acid-polylactic acid copolymer are self-assembled by means of the electrostatic interaction to form a multifunctional composite micelle; the solubility of insoluble tumor medicaments and the drug loading capacity and encapsulation efficiency of water-soluble anti-tumor medicines can be remarkably improved by virtue of the anti-cancer drug-loaded micelle and composite micelle composition, the medicines can be biodegraded in a body, phagocytosis of a reticuloendothelial system (RES) and excretion of a kidney can be avoided. The active targeted hyaluronic acid-polylactic acid carrier has a long-circulating effect, the multifunctional composition has a prominent advantage of tumor active targeting effect, and parameters of pharmacodynamics in vitro and in vivo of the micelle are remarkably superior to those of common anti-tumor injections. Clinically acceptable administration means of the micelle includes injection administration or mucosal administration, and preparations of the micelle can be injection, transfusion, injection lyophilized powder injections or dry powder inhalation.

By blending glycyrrhizin with an ester mixture comprising a C6-18 fatty acid glycerol ester with a C6-18 fatty acid macrogol ester, glycyrrhizin can be efficiently absorbed via mucosae, in particular, digestive mucosae to achieve a therapeutically effective plasma glycyrrhizin concentration.

The invention discloses a preparation method of fresh kiwi fruit slices. The preparation method comprises the following steps: taking fresh high-quality kiwi fruits of which the hardness is between 9.0 kg / cm<2> and 11.0 kg / cm<2> as standard raw materials, putting slices into distilled water after washing, peeling and cutting the kiwi fruits, pumping ozone until the concentration is 0.8 to 1.0 mg / L, and carrying out ultrasonic assisted sterilization for 5 to 8 minutes; then, adding the slices into a kiwi fruit mixed color protecting solution which is prepared from 0.2 percent of ZnCl2, 0.25 percent of EDTA (Ethylene Diamine Tetraacetic Acid)-2Na, 0.10 percent of ascorbic acid and 0.1 percent of citric acid for carrying out color protection, and infiltrating by using 0.5 to 2.0 percent of PEG (Polyethylene Glycol)-chitosan edible coating film after dewatering; finally, packaging by using a PP (Propene Polymer) pallet and a PE (Poly Ethylene) film, and storing at low temperature. The fresh kiwi fruit slices prepared through the preparation method have the characteristics that the appearance color is well kept, browning is not easy to cause, the bacteria inhibiting and fresh keeping effects are good, the storage period is long, and the quality is stable.

The invention discloses a preparation method of non-thermal-processed kiwi fruit juice. The preparation method of the non-thermal-processed kiwi fruit juice comprising the following steps: taking fresh kiwi fruits as raw materials; carrying out washing, removing hairs from the washed kiwi fruits, and carrying out first juicing; filtrating the juice, adding a compound enzyme preparation into the filtrated kiwi fruit residues so as to carry out enzymatic hydrolysis; carrying out second juicing so as to effectively improving juice yield and production efficiency by adopting a method combining two-time squeezing and enzymatic hydrolysis; adjusting pH value of the kiwi fruit juice to 3-4, adding 0.04% of chitosan into the pH-value-adjusted kiwi fruit juice so as to achieve the purposes of clarifying and removing astringency, and providing the best bacteriostatic conditions to the chitosan; and finally, further carrying out enzyme-inactivation and sterilization on the juice by utilizing an ultrahigh-pressure sterilizing technology for 15-25 minutes, wherein the pressure is 400-600Mpa. Combination of the ultrahigh-pressure sterilizing technology and the chitosan bacterium-inhibiting technology makes the prepared kiwi fruit juice clear, free of astringency, stable in color and luster as well as few in nutrient loss; moreover, storage life of the kiwi fruit juice is up to 30 days.

The invention belongs to the technical field of culture machinery and discloses an automated-cleaned sheep house. The automated-cleaned sheep house comprises a bottom board, a house top board and lateral plates, wherein the house top board is located above the bottom board, and the lateral plates are located between the bottom board and the house top board; a plurality of excretion strip holes are formed in a board face of the bottom board at intervals, a guide rail is arranged on the house top board, a gear rack is arranged on a bottom face of the guide rail, a roller is mounted in a guiding groove in a side face of the guide rail and is in running fit with a connecting plate, a brush holder is fixed at the lower end of the connecting plate, and a driving gear is mounted in the middle of the connecting plate through a rolling bearing and is engaged with the gear rack; and a sloping plate is mounted at one side of the bottom board, a moving plate which faces the sloping plate is mounted on the brush holder, the distance between the moving plate and the board face of the bottom board is 2-10cm, and a brusher which is opposite to the sloping plate is mounted at the lower end of the brush holder and is in contact with the board face of the bottom board. According to the automated-cleaned sheep house, during the cleaning of sheep manure, sheep flocks are not required to be released, the cleaning is quick and efficient, and the labor cost is low.

This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardio-vascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.

An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect.The present invention provides a compound represented by the general formula (I):(wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and / or improving symptoms thereof, containing them as an active ingredient.

The invention discloses a drain-off device for preventing generation of steam locking favorably. The drain-off device comprises a left valve deck and a right valve deck. A condensate water accommodation chamber is arranged between the left valve deck and the right valve deck; an inlet tube and an outlet tube are arranged on the left valve deck and the right valve deck; a floating ball is arranged in the condensate water accommodation chamber. The drain-off device also comprises an emptier. The emptier comprises a thermal static metal piece, a sealing ball and a steam locking discharging runner; the front end and the back end of the steam locking discharging runner are connected with the condensate water accommodation chamber and the outlet tube respectively; the sealing ball is fixed on the thermal static metal piece, and directly faces the front end of the steam locking discharging runner; the section of the thermal static metal piece is a diamond; the sealing ball is positioned in the apex angle of the diamond. By applying the drain-off device, automatic discharging of non-condensable gas can be realized, and the service life is long.

An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect.The present invention provides a compound represented by the general formula (I):(wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and / or improving symptoms thereof, containing them as an active ingredient.

An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect.The present invention provides a compound represented by the general formula (I):(wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and / or improving symptoms thereof, containing them as an active ingredient.

The invention discloses a garbage drying device for garbage disposal, which comprises a main hollow shell with support legs fixed at the bottom, a drying space is arranged in the center of the main hollow shell, and a drying space at the bottom of the main hollow shell. A first motor is fixed at the center, the first motor shaft of the first motor runs through the main hollow casing, and the end is located inside the drying space, and a stirring blade is fixed at the end of the first motor shaft, The side of the main hollow shell is provided with a garbage discharge pipe integrated with it at the bottom of the dry space. The invention can dry and deodorize the garbage, use the resistance wire heating technology to effectively heat the incoming air, and perform effective garbage drying treatment under the condition of constantly turning the garbage, thereby effectively speeding up the working efficiency , In addition, the device can effectively prevent the air odor caused by drying from being discharged into the external space, and has strong practicability.

It is an object of the present invention to provide an ABC transporter inhibitor whereby the multi-drug resistance against anticancer drugs caused by amplification and expression of MDR1 gene, which is the most serious problem in chemotherapy for cancer, or the resistance against antifungal agents in mycotic diseases can be overcome. The present invention relates to an ABC transporter inhibitor containing enniatin or its analog as the active ingredient. The ABC transporter inhibitor of the present invention, being capable of inhibiting transport / excretion of a drug, especially an anticancer drug or an antifungal agent, from inside to outside of cells, is useful in preventing, suppressing, or inhibiting acquisition of resistance against various drugs.

The invention belongs to the technical field of cultivation machinery and discloses a sheep cot cleaning device. The sheep cot cleaning device is installed in a sheep cot and comprises a base plate, a sheep cot top plate above the base plate, and a surrounding plate located between the base plate and the sheep cot top plate, wherein multiple discharge strip holes are formed in the surface of the base plate at intervals, an oblique plate is installed on one side of the base plate, and a guide rail is arranged on the sheep cot top plate and connected with a vertical connecting rod in a sliding mode; a mane brush in contact with the base plate is fixed to the lower end of the connecting rod, a ball screw is installed on the surrounding plate, a screw body of the ball screw is parallel to the guide rail, one end of the screw body is fixedly connected with the connecting rod, the other end of the screw body is supported by the surrounding plate, and a driven gear is welded to the outer circle of a nut of the ball screw; the driven gear is meshed with a driving gear installed on the surrounding plate, and the driving gear is driven by a rotary motor. Compared with a traditional sheep bed, the device has the advantages that sheep do not need to be out during sheep manure cleaning, the whole process is achieved automatically without man power required, cleaning speed is high, and the device is suitable for centralized management type farms.

The invention discloses a green ecological roof structure. The green ecological roof structure comprises a roof body, fan blades, flowerpots, solar photovoltaic panels and a PLC. The roof body is in an inverted V shape, and the top of the roof body is in a convex arc shape. The top end of the roof body is provided with a wind wheel, and the fan blades are installed on the wind wheel. The wind wheel is connected with a transmission gear box through a connecting shaft. The transmission gear box is in shaft connection with an electric generator. One side of the electric generator is provided witha storage battery. The two sides of the roof body are provided with planting areas, and each planting area is internally provided with three bamboo plates transversely and fixedly. A water leaking hole is formed in the bottom of each flowerpot. The bottoms of the flowerpots are connected with first water pipes. The first water pipes communicate with water tanks. The water tanks are arranged on the lower portions of the solar photovoltaic panels. A second water pipe communicates with the side, close to an eave, of each water tank. The tail end of each second water pipe extends out from the eave of the roof body. Green plants are planted through the flowerpots, so that the beauty is not only increased, but also coolness is brought to the interior of a room; and the green ecological roof structure is reasonable in design, practical, feasible and suitable for use and popularization.

The invention provides a power distribution type lightning arrester preventing sparks in a pressure release process. When thunder and lightning and overvoltage occur, an overvoltage arc release path is formed by arc control panels under the point effect, overvoltage is rapidly released, and accordingly, lines and the lightning arrester are protected; by means of semi-ring grooves and longitudinalgrooves in the surfaces of upper electrodes, lower electrodes and intermediate electrodes, recombination of the electrodes and a casing is facilitated, adhesive force of the electrodes and the casingcan be improved, damp air is prevented from entering the casing, the risk of flash explosion is reduced, overall mechanical strength can be improved when the upper electrodes, the lower electrodes andthe intermediate electrodes are combined with components such as resistor discs, the casing and the like, bending resistance and torsional strength of the lightning arrester are improved, and the probability of disassembly of the lightning arrester in a pressure release process is greatly reduced; the electrodes are made of stainless steel instead of common aluminum or aluminum alloys, the electrode melting point is increased to 1,360 DEG C or higher from about 660 DEG C, and the probability of melt dropping of the electrodes is reduced.

The invention discloses a photovoltaic integrated solar light condensation device which comprises a shell and is characterized in that a light following mechanism is arranged at the bottom end of the shell, a cutting mechanism is arranged below the light following mechanism, a light condensation mechanism is arranged at the top end of the shell, and a driving mechanism is arranged on the periphery of the upper plate part of the shell. Extrusion bags are arranged below the two ends of the light gathering mechanism, a first air cylinder is arranged in the light gathering mechanism, a first piston is slidably connected into the first air cylinder in a sleeved mode, a push rod is welded to the top end of the first piston, a photovoltaic assembly is fixed to the top end of the push rod, and first flexible bags are arranged on the two sides of the top end of the light gathering mechanism; and an expansion bag is arranged in the first flexible bag, heat conduction balls are arranged at the two ends of the expansion bag and arranged outside the first flexible bag, and a collecting lens is connected to the top end of the first flexible bag in a penetrating mode.

The invention discloses a microporous membrane-coated controlled-release trelagliptin succinate pellet and a preparation method thereof. The microporous membrane-coated controlled-release trelagliptin succinate pellet sequentially comprises a drug-containing pellet core and a controlled-release coating layer from inside to outside, wherein the drug-containing pellet core is prepared from a primary material and an auxiliary material at the ratio of (5%-20%):(80%-95%). According to the microporous membrane-coated controlled-release trelagliptin succinate pellet, a bitter taste can be coated, the effective ingredients can be dissolved out, constant long-acting plasma concentration is ensured, and the defect that a drug is discharged along with excrement before not completely released is avoided.

The present invention relates to a preparation method and an application of a hyaluronic acid-antitumor drug conjugate and composite nanoparticle composition with characteristics of active targeting antitumor effect and biodegradability. The preparation method is characterized by comprising: (1) a synthesis method for conjugating an antitumor drug and a spacer and conjugating a targeting ligand hyaluronic acid or an ammonium salt thereof and the antitumor drug-spacer; and (2) a new technology for assembling the hyaluronic acid-antitumor drug conjugate and amphiphilic polyester block copolymer composite nanoparticles. The composition has effects of substantially increased drug loading, efficacy improving, in vivo long-circulating effect achievement, active tumor targeting property and drug toxic-side effect reduction. The macromolecular conjugate and complex nanoparticle composition can be used for injection administration, oral administration or mucosal administration. In addition, the preparation method has characteristics of mature process and high yield, and is suitable for industrial production.

The invention relates to a bird thorn capable of being hung on an overhead ground wire, in particular to a hanging type anti-falling bird thorn, and belongs to the technical field of power transmission safety protection. The hanging type anti-falling bird thorn comprises a plurality of bird pricking needles, one ends of the plurality of bird pricking needles are scattered and are arranged in a radial shape, and the other ends of the bird pricking needles are fixed through a bundle cylinder; the bundle cylinder is arranged above a connecting plate; two bolt holes I are formed in the connectingplate below the bundle cylinder; the connecting plate between the two bolt holes I is set as an arc-shaped positioning end matched with an overhead ground wire; a fixed plate is also arranged below the bundle cylinder; bolt holes II corresponding to the two bolt holes I are formed in the upper portion and the lower portion of the fixed plate respectively, an arc-shaped fixing end corresponding tothe arc-shaped positioning end is arranged between the bolt holes II, the fixed plate and the connecting plate are fixed through bolt assemblies penetrating through the bolt holes I and the bolt holesII, and the bottom of the connecting plate is connected with a shockproof hammer. The hanging type anti-falling bird thorn is simple in structure, reasonable in design, capable of reducing occurrenceof bird droppings flashover accidents after being used and high in practicability.

The invention discloses a small molecule polypeptide stock solution. The small molecule polypeptide stock solution is prepared from the following components in parts by weight: 16-36 parts of sodium hyaluronate, 8-28 parts of hyaluronic acid, 0.5-5 parts of a vitamin B12, 2-15 parts of silk peptide powder, 2-14 parts of hydrolyzed collagen, 2-13 parts of polyglutamic acid and 0.5-5 parts of ceramide 3. The invention further discloses a preparation method of the small molecule polypeptide stock solution. The small molecule polypeptide stock solution and the preparation method have the followingprominent effects that the excellent beauty and anti-wrinkle health care function is achieved, the moisturizing effect is good, skin nutrition supply and waste excretion can be promoted, thus skin aging is prevented, and beauty and skin nourishing effects are achieved; repairing and prevention effects of skin damage are achieved; excellent lubrication property and film-forming property are achieved, when the small molecule polypeptide stock solution is applied to skin, a thin film can be formed on the surface of the skin, so that the skin produces a good feeling of smoothness and moisture, and the protection effect on the skin is achieved.

The invention relates to the technical field of food processing, and discloses a rice airing device which comprises a supporting ring, the top of the supporting ring is rotationally connected with a rotary disc, the top of the rotary disc is fixedly connected with a telescopic column, the surface of the telescopic column is fixedly connected with an elastic piece, a working mechanism and a discharging mechanism are arranged on the surface of the elastic piece, a collecting box is clamped to the surface of the rotary disc, a limiting plate is fixedly connected to the surface of the rotary disc, a rotating plate is rotatably connected to the inner wall of the rotary disc, and a plurality of balls are welded to the inner wall of the rotary disc and the top of the rotary plate. When birds want to eat rice, the birds can fall over the elastic piece or an upper elastic plate, at the moment, the elastic piece and the upper telescopic plate can form a net shape to prevent the birds from eating the rice, meanwhile, the elastic piece can be pressed to move downwards under the weight of the birds to drive a connecting plate to impact the elastic piece, the birds fly away when feeling impact, and the birds are prevented from staying above to cause excretion.

The invention discloses an automobile rain sheltering device. The automobile rain sheltering device comprises a sliding pole, a gear, a rain tent, a positioning rod, a humidity sensor, a motor and a controller, wherein an accommodating groove for allowing the motor, the gear and the sliding pole to be accommodated therein is formed in the top of an automobile frame; the motor is laterally and fixedly arranged in the accommodating groove; an output shaft of the motor is fixedly connected with the gear; the lower edge of the sliding pole is mutually meshed with the gear; the positioning rod is fixedly arranged in the accommodating groove; the sliding pole is laterally slidingly connected to the middle end of the positioning rod; the left end of the rain tent is fixedly connected with the positioning rod, and the right end of the rain tent is fixedly connected with the right end of the sliding pole; and the controller is electrically connected with the humidity sensor and the motor. According to the automobile rain sheltering device disclosed by the invention, through the humidity sensor, the humidity is detected; the controller controls the motor to work; the rain tent is driven by the sliding pole to extend to a position above a front automobile window of an automobile, so that rain sheltering for the automobile is realized, a driver can see clearly the road surface, and the safety of the driver is guaranteed; and when the situation that animals including birds and the like are pressed on the automobile is detected by the pressure sensor, the controller controls a loudspeaker to whistle for frightening the birds away, so that the cleanness and neatness of the vehicle are guaranteed to a certain extent.