49 results about "Tocophersolan" patented technology

An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.

This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.

A formulation to deliver a full-spectrum of Vitamin E isomers for improved antioxidant capacity, bioavailability, dissolution and efficacy. The formulation includes dl-α-tocopheryl acetate or dl-α-tocopheryl succinate (synthetic Vitamin E), natural Vitamin E and mixed tocopherols, such as α-, β-, γ- and δ-tocopherol, as well as four isomers (α, β, γ and δ) of tocotrienols. This formulation is designed to deliver at least 17-times the antioxidant capacity of synthetic Vitamin E (dl-α-tocopheryl acetate), and at least twice the antioxidant capacity of natural Vitamin E (d-α-tocopherol) as measured by oxygen radical absorbance capacity (ORAC) assay. The potent antioxidant capacity of this formula affords protection against oxidative damage of cell membranes, heart disease, cancer and eye and skin disease.

The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of α-tocopheryl acetate; α-tocopheryl acetate and about 0.5% aqueous component; or α-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.

The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of α-tocopheryl acetate; α-tocopheryl acetate and about 0.5% aqueous component; or α-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.

The invention relates to an environmental response type anti-tumor nanometer medicine with high medicine loading capacity, a carrier and a preparation method thereof. The nanometer medicine comprisesan amphiphilic polymer carrier and a medicine prodrug; the amphiphilic polymer carrier comprises a hydrophilic segment and a hydrophobic segment which are connected mutually; the hydrophilic segment comprises polyethylene glycol or poly(N-(2-hydroxypropyl)methacrylamide); the hydrophobic segment comprises D-alpha-tocopherol succinate; the medicine prodrug comprises a medicine for treating tumor aswell as a hydrophobic chain segment which is connected with the medicine through a chemical bond; and the hydrophobic chain segment comprises D-alpha-tocopherol succinate. The nanometer medicine hasthe characteristics of high medicine loading capacity, environmental responsiveness and adjustable and controllable grain size, and can achieve the properties that the tumor penetration ability is high, the tumor cell multidrug resistance is achieved, drug-resistant cells are killed in advance, tumor related fibroblast is not killed and tumor stem cells can be killed effectively according to composition of different polymers and the loaded prodrug molecule types.

The invention provides a less-harmful nontoxic rubber vehicle sealing strip which has excellent processability and physical properties and belongs to an environment friendly sulfidizing system. Main raw materials are as follows: 200 plus or minus 10 portions of ethylene propylene diene methylene, and 150 plus or minus 10portions of carbon black; 20 plus or minus 2 portions of light super fine calcium carbonate and 30 plus or minus 3 portions of talc as fillers; 20 plus or minus 2 portions of high-flash paraffin oil or styrene / Alpha-methyl styrene / vinyl toluene terpolymer as a softener; 10 plus or minus 1 portions of aluminum hydroxide as a flame retardant; 5 plus or minus 0.5 portions of zinc oxide and 2 plus or minus 0.2 portions of stearic acid as active agents together; 4 plus or minus0.4 portions of polyethylene glycol of a hydroxyl polar group as an additive; 5 plus or minus 0.5 portions of calcium oxide as a neutralizer; 4 plus or minus 0.4 portions of nitrogen-free sulfidationmaterial which is mainly sulphur; and 0.3 plus or minus 0.03 portion of Alpha-tocopherol as an inhibitor. The less harmful nontoxic rubber vehicle sealing strip can not only reduce environmental pollution, but also maintain reasonable cost.

The invention relates to the field of skin care products, in particular to a mineral spring rejuvenating lotion and a preparation method thereof. The mineral spring rejuvenating lotion comprises water, 1,3-propylene glycol, glycerinum, trehalose, nicotinamide, cyanocobalamin, phenoxyethanol, allantoin, sodium hyaluronate, 3-o-ethyl ascorbic acid, panthenol and hydrolyzed collagen. Through a synergistic effect of multiple vitamins of the nicotinamide, 3-o-ethyl ascorbic acid, panthenol, cyanocobalamin and tocopherol, in cooperation with raw materials such as hydrolyzed collagen, trehalose and sodium hyaluronate, the mineral spring rejuvenating lotion is prepared, skin pores are purified, convenience is provided for the skin to absorb nutrient components, the water flocculation texture of the skin is restored, the translucent feeling and softness of the cuticle are maintained, and a mineral spring skin care lotion is supplemented, so that the skin feels active, moisturized and transparent; the vitamin B12 and sodium hyaluronate supplement each other, the skin metabolism is improved, absorption is promoted, the self-protection force of the substrate is effectively improved, and the conditions of dull skin and lowered elasticity are reduced; the spots are faded, the skin color is balanced, whiting and shining are achieved, the skin is transparent and free of speckles, and the skinis lustrous, transparent, bright and white.

Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:{X—OOC—[(CH2)n—COO]m}p—Y  (I)wherein:X is a residue of a hydrophobic moiety,Y is a residue of a hydrophilic moiety,p is 1 or 2,m is 0 or 1, andn is an integer greater than or equal to 0are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is α-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.

The present disclosure relates to antioxidant compositions comprising a high amount of stabilized neohesperidin dihydrochalcone. The antioxidant compositions may further include additional antioxidants, such as ferulic acid, and tocopherols. The compositions include at least 20 wt. % of one or more water-soluble solvents, such as propanediol, which contribute to the surprising solubility and stability of the compositions. The antioxidant properties of the compositions make them particularly effective for treating and protecting the skin. For example, the compositions are useful for protecting the skin from environmental insult.

The present invention relates to a deterioration preventive for a flavor component, which is an oil-in-water and / or -polyhydric alcohol type emulsion, comprising an extracted tocopherol, wherein d-δ-tocopherol is contained in an amount of 45% by weight or more of a total tocopherol, ferulic acid and / or a derivative thereof, and a polyglycerol fatty acid ester; a deterioration preventive for a flavor component, which is an oil-in-water and / or -polyhydric alcohol type emulsion, comprising (A) the above-mentioned extracted tocopherol, (B) ferulic acid and / or a derivative thereof, and (C) an emulsifying agent having an HLB of 9 or more; a flavor for foodstuff, comprising the above-mentioned deterioration preventive; an emulsion flavor for foodstuff, comprising the above-mentioned extracted tocopherol, a catechin; and a polyglycerol fatty acid ester; and foodstuff comprising the above-mentioned deterioration preventive for a flavor component, the above-mentioned flavor for foodstuff, or the above-mentioned emulsion flavor for foodstuff.