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Method of enhancing bioavailability of DHA and other lipid-soluble nutrients

A nutrient and fat-soluble technology, applied in application, pharmaceutical formulation, food science, etc., can solve problems such as not improving the bioavailability of α-tocopherol

Inactive Publication Date: 2015-12-23
ABBOTT LAB INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although replacement of long-chain triglycerides with medium-chain triglycerides improved fat digestion by up to 10%, MCT inclusion did not improve alpha-tocopherol bioavailability
Thus, the high bioavailability of fat-soluble nutrients is unlikely to be due to higher breast milk fat digestion alone

Method used

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  • Method of enhancing bioavailability of DHA and other lipid-soluble nutrients

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Embodiment

[0067] Table 2 below shows a list of materials used to produce 1,000 lbs (approximately 454 kg) of powder that can be reconstituted into infant formula and used according to the methods of the present disclosure. The nutritional product may be prepared by any known or otherwise effective manufacturing technique for the product form selected for manufacture. For any given product form, such as nutritional liquids and nutritional powders, many such techniques are known and can be readily applied to the nutritional products described herein by one of ordinary skill in the nutritional and formulation arts.

[0068] For example, a liquid, milk or soy-based nutritional liquid can be prepared by first forming an oil and fiber blend containing all formulated oil (fat), any emulsifiers, fiber, Fat-soluble nutrients and other fat-soluble (fat-soluble) vitamins. Additional slurries (usually carb and two protein slurries) are prepared separately by mixing together carbs and minerals and ...

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Abstract

A method of enhancing the bioavailability of a lipid-soluble nutrient, such as DHA, arachidonic acid, tocopherol, and carotenoids, in a newborn or preterm infant is disclosed. In this method, the lipid-soluble nutrient is administered in a nutritional product (such as an infant formula) to a preterm or newborn infant. The nutritional product comprises (a) an effective amount of the lipid-soluble nutrient; and (b) a fatty component comprising a combination of: (i) at least 6 g / l predigested fat, wherein the predigested fat includes at least one of: monoglycerides, free fatty acids, or a combination of monoglycerides and free fatty acids, and (ii) at least 1.44 g / l phospholipid. A method of enhancing cognition in newborn or preterm infants utilizing the nutritional product is also disclosed.

Description

[0001] Cross References to Related Applications [0002] This application claims priority and any benefit to US Provisional Application No. 61 / 779,006, filed March 13, 2013, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure relates to nutritional products and methods of using those products to enhance the bioavailability of fat-soluble nutrients such as DHA. Background technique [0004] Various fat-soluble nutrients, such as docosahexaenoic acid (DHA), arachidonic acid (AA), vitamin A, vitamin E, vitamin D, and vitamin K, and carotenoids, such as lutein, tomato Erythrin, beta-carotene, beta-cryptoxanthin and zeaxanthin, are well known in the art and serve important nutritional functions in the body. For example, DHA is a major structural component of the human brain's cerebral cortex, sperm, testes, and retina. In fact, it is the most abundant omega-3 fatty acid in the brain and retina. It regulates carrier...

Claims

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Application Information

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IPC IPC(8): A23L1/30A23L1/29A61K9/00A23L33/00
CPCA23L33/40A23L33/105A23L33/115A23L33/12A23V2002/00
Inventor C-S.赖R.布丁顿J.莱斯肯
Owner ABBOTT LAB INC
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