The invention relates to protein allergy-resisting and nutritious infant formula milk powder. The milk powder is prepared from the following raw materials in part by ton weight: 1,000 parts of fresh milk (115 parts of dried substance), 500 parts of demineralized whey powder, 235 parts of refined vegetable oil, 45 parts of lactose, 50 parts of whey small peptide with the molecular weight of less than 10,000 daltons, 20 parts of fructooligosaccharide, 6 parts of arachidonic acid (ARA), 5 parts of docosahexaenoic acid (DHA), 0.42 part of nucleotide, 0.45 part of taurine, 0.42 part of choline, 0.06 part of L-carnitine, 0.012 part of beta-carotene, 2.5 parts of complex vitamin, 3.5 parts of amino acid common trace element chelate and 1.5 parts of selenium-enriched yeast powder. The formula milk powder has the advantages that: the formula milk powder contains the whey small peptide with the molecular weight of less than 10,000 daltons, has the effects of regulating immunity and resisting protein allergy, has the characteristics of high water solubility, high absorptivity, no stimulus on stomach and intestine and the like, and can meet the requirements of human bodies on the supplement of trace elements and amino acid.