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Glycyrrhetic acid and phospholipid composites of glycyrrhetate and process for preparing same

A technology of phospholipid complex and glycyrrhizinate, which is applied in the direction of edible phospholipid composition, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of poor absorption of glycyrrhizic acid in the digestive tract, poor curative effect, and side effects major issues

Active Publication Date: 2005-03-16
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of chronic liver diseases, the curative effect of oral preparations of glycyrrhizic acid is obviously not as good as that of injections, and the side effects are also large. The main reason is that glycyrrhizic acid or its salts are highly polar and hydrophilic macromolecules, which are poorly absorbed in the gastrointestinal tract.
[0005] Diammonium glycyrrhizinate is obtained by refining glycyrrhizic acid after two-step ammonification. Improves the characteristics of poor absorption of glycyrrhizic acid in the digestive tract, but the effect is limited

Method used

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  • Glycyrrhetic acid and phospholipid composites of glycyrrhetate and process for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0073] Add 100g of soybean lecithin to 1000ml of methanol-water (6:1) mixed solution, heat to 80°C, reflux and dissolve, then add 100g of diammonium glycyrrhizinate passed through a 60-mesh sieve, stir and reflux to make the solution clear, The solvent is recovered under reduced pressure, dried, pulverized, and passed through a 60-mesh sieve.

Embodiment 2

[0075] Add 10g of soybean lecithin to 300ml of ethanol, heat to 40°C, let it reflux to dissolve, add 100g of diammonium glycyrrhizinate passed through a 60-mesh sieve, stir and reflux to make the solution clear, recover the solvent under reduced pressure, dry, and pulverize. Pass through a 60-mesh sieve.

Embodiment 3

[0077] Add 2000g of soybean lecithin to 1500ml of acetone, heat to 60°C, reflux and dissolve, then add 100g of diammonium glycyrrhizinate passed through a 60-mesh sieve, stir and reflux to clarify the solution, recover the solvent, dry, pulverize, pass through 60 Mesh sieve, that is.

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Abstract

The invention provides a glycyrrhetic acid and phospholipid composites of glycyrrhetate and process for preparing same by forming phospholipid compound in suitable dissolvent from glycyrrhizinic acid and its salts with a definite quantity of lecithin, thus converting the physical and chemical property, and improving the bioavailability of the glycyrrhizic acid and its salts.

Description

technical field [0001] The invention relates to a phospholipid complex of glycyrrhizic acid and its salt and a preparation method thereof. Background technique [0002] The root of the natural plant medicine Glycyrrhiza Uralensis mainly contains glycyrrhizic acid in 18-β configuration and a very small amount of glycyrrhizic acid in 18-α configuration. The chemical name of glycyrrhizic acid is 20β-carboxy-11-oxo-normal Aranane-12-ene-3β-yl-2-O-β-D-glucopyranuronyl-α-D-glucopyranuronic acid, the structural formula is as follows: [0003] [0004] Through a certain reaction, the glycyrrhizic acid in the 18-β configuration can be converted into the glycyrrhizic acid in the 18-α configuration, see Chinese Patent Publication No. CN1381462A. At present, some preparations of glycyrrhizic acid and its salts have been listed at home and abroad. Foreign preparations with monoammonium glycyrrhizinate as the main component include compound glycyrrhizin tablets, such as "Glycyron" (G...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K47/24A61P1/16A61P31/12C07F9/10
Inventor 张来芳夏春光张喜全
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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