A method of treating a disorder of a patient, such as a neurological disorder, is provided. The method comprises intravascularly delivering at least one of a stimulation lead and a sensing lead within the head of the patient. For example, one or both of the leads can be delivered into the patient's head via the circulatory system (e.g., vein or artery) or the ventricular system (e.g., through the intrathecal space of the spine). The method further comprises sensing a physiological event associated with the disorder (e.g., physiological electrical activity, a blood parameter, or intracranial pressure) using the sensing lead, and stimulating neural tissue with the stimulation lead in response to the sensed physiological event.