33 results about "Normal blood flow" patented technology

A multiple-sided medical device comprises a closed frame of a single piece of wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration that comprises a self-expanding stent. The stent is pushed from a delivery catheter into the lumen of a duct or vessel. One or more barbs are attached to the frame of the device for anchoring or to connect additional frames. A covering of fabric or other flexible material such as DACRON, PTFE, or collagen, is sutured or attached to the frame to form an occlusion device, a stent graft, or an artificial valve such as for correcting incompetent veins in the lower legs and feet. A partial, triangular-shaped covering over the lumen of the device allows the valve to open with normal blood flow and close to retrograde flow.

A method and system for non-invasive measurements in a patient's body in which several measurement sessions are performed on a measurement location. Each measurement session includes applying an external electromagnetic field to the measurement location, detecting at least two responses of the measurement location, and generating data indicative of the detected response. These responses are characterized by at least two different values of a controllable parameter. The measurement sessions include at least two measurement sessions carried out at a normal blood flow in the measurement location and at least two measurement sessions carried out at a condition of artificial kinetics in the measurement location. The first and second measured data are processed to determine a first relation between the first time variations and a second relation between the second time variations for the different parameter. that can be used to determine the at least one blood related parameter.

A method and system for measuring time variations of a response of a blood perfused fleshy medium to an external electromagnetic field is provided. The response of the medium to the external electromagnetic field can be a photo-acoustic signal, obtained in response to the exciting light, and / or impedance of the medium, in response to the applied ac electromagnetic field. Measurements of the time variations of the response of the medium are carried out when the condition of artificial kinetics is created and maintained over a certain time period by applying primary over-systolic pressure to a certain location at the medium with normal blood flow, so as to achieve a state of temporary blood flow cessation at the medium downstream of the certain location. When required, the control of the condition of the artificial kinetics can be further achieved by applying a perturbation of secondary pressure to the fleshy medium.

The invention discloses a covered stent, which comprises a support structure and a tectorial membrane unit, and is characterized in that: the tectorial membrane unit comprises an inner-layer tectorial membrane and an outer-layer tectorial membrane which coats the support structure; the outer-layer membrane coats on the outer side of the inner-layer tectorial membrane; the inner-layer tectorial membrane is a biological membrane with good blood compatibility, and the outer-layer tectorial membrane is a biological membrane which is easy to induce the formation of thrombus; the inner-layer tectorial membrane contacting blood has good blood compatibility, can effectively reduce the formation of the thrombus, and maintains normal blood flowing channels; and the outer-layer tectorial membrane can induce the formation of the thrombus in aneurysm or thrombus of bleeding parts, promotes the aneurysm to be quickly activated and reduced, reduces the mass effect in vivo, simultaneously effectively adheres endothelial cells, promotes differentiation and proliferation of cells, quickens the endothelialization of lesion parts of vessels, and can more effectively treat vascular diseases such as the aneurysm and the like.

A cannulation system (10) for perfusing a patient's circulatory system, includes an inflow cannula (14) having a first end adapted to be connected to said circulatory system and a second end adapted to be connected to a blood pump (19), an outflow cannula (23) having a first end adapted to be connected to the blood pump (19) and a second end adapted to be connected to said circulatory system at a location downstream of the first end of the inflow cannula. The flow of blood from the pump (19) is in series with the normal blood flow of the circulatory system of the patient and creates a localized region of hypertension.

An apparatus to minimize and / or eliminate the effects associated with reperfusion injury consisting of an external pump, heat exchanger and control unit creating a flow loop whereby blood is moved from the body via a pump, cooled by an external heat exchanger and reintroduced into a specific location, thereby locally cooling the surrounding tissue and inducing localized hypothermia to minimize tissue injury resulting from ischemia and the effects associated with reperfusion injury as an obstruction is removed and normal blood flow is restored and including the ability to locally measure pressure and temperature in the body.

The present invention relates to a vascular filter including a coiled wire formed of a shape memory material for implantation into a vessel. The vascular filter captures particulates within the blood flow in the vessel, without substantially interfering with the normal blood flow. Prior to implantation, the coiled wire is generally elongated and thereafter it reverts to a predetermined shape that is suitable for filtering the blood flow. The predetermined shape of the vascular filter includes a plurality of loops coaxially disposed about a longitudinal axis and has a conical portion and a cylindrical portion.

A blood pumping system for supplementing distal blood perfusion comprising a blood pressure altering device in the form of a blood pump (1) having an inlet (10) and an outlet (9) which also includes an upstream end (2) and a downstream end (4). The blood pressure altering device (1) cooperates with a circulatory system of a patient (15) to promote blood flow throughout at least one or more distal regions including limbs, a brain region of a patient by altering vascular blood pressure. The blood pressure altering device (1), when in use, is positioned in series with the normal blood flow of the circulatory system of a patient (15).

A method and system for non-invasive measurements in a patient's body in which several measurement sessions are performed on a measurement location. Each measurement session includes applying an external electromagnetic field to the measurement locations, detecting at least two responses of the measurement location, and generating data indicative of the detected response. These responses are characterized by at least two different values of a controllable parameter. The measurement sessions include at least two measurement sessions carried out at a normal blood flow in the measurement location and at least two measurement sessions carried out at a condition of artificial kinetics in the measurement location. The first and second measured data are processed to determine a first relation between the first time variations and a second relation between the second time variations for the different parameter that can be used to determine the at least one blood related parameter.

A device comprising a single closed loop of elastic filament configurable between (i) a first configuration for movement along a blood vessel; and (ii) a second configuration for lodging within a blood vessel, the second configuration providing a single flow-restricting face sized and configured to cover the mouth of the aneurysm and obstruct blood flow to the aneurysm while permitting substantially normal blood flow through the blood vessel, with the degree of obstruction at the mouth of the aneurysm being such that the aneurysm thromboses when the face is positioned over the aneurysm, the flow-restricting face comprising a plurality of lengths of the closed loop of filament disposed in close proximity to one another in a switchback configuration, and at least one leg for holding the flow-restricting face adjacent the mouth of the aneurysm, the leg configured so as to maintain substantially normal blood flow through the blood vessel.

The invention discloses a blood flowing detection device and method. The detection device comprises an inflation pressure binding belt, a detection host, as well as a temperature sensor and a humidity sensor which are connected with the detection host; and the detection host comprises a control button, a switching voltage-stabilized power supply circuit, a singlechip microcomputer central control-processing unit, a preamplifier, an A / D (analog-to-digital) conversion circuit, a display and a buzzer. The detection method comprises the following steps: releasing restriction after a blood flow atthe proximal end of a heart is restrained for a certain period of time; measuring changes of skin temperature and humidity on a position at a distal end of the heart, and comparing the changes with the standard parameters of people with a normal blood flowing condition; determining whether a testee has vascular endothelial dysfunction or not; and evaluating the severity of early symptoms of cardiovascular sclerosis and hemodynamics of the testee. The detection device has the advantages of simple structure, low cost and convenience for operation, causes no trauma or pain, and can be used for routine physical examination and community general examination.

A method and system for measuring time variations of a response of a blood perfused fleshy medium to an external electromagnetic field is provided. The response of the medium to the external electromagnetic field can be a photo-acoustic signal, obtained in response to the exciting light, and / or impedance of the medium, in response to the applied ac electromagnetic field. Measurements of the time variations of the response of the medium are carried out when the condition of artificial kinetics is created and maintained over a certain time period by applying primary over-systolic pressure to a certain location at the medium with normal blood flow, so as to achieve a state of temporary blood flow cessation at the medium downstream of the certain location. When required, the control of the condition of the artificial kinetics can be further achieved by applying a perturbation of secondary pressure to the fleshy medium.

An over-systolic pressure is applied to a patient's blood perfused fleshy medium. The pressure causes a state of temporary blood flow cessation within a time period insufficient for irreversible changes in the fleshy medium. Release of the over systolic pressure causes a state of transitional blood flow terminating with the normal blood flow. At least two sessions of measurement, separated in time, are executed and at least one of these sessions is selected within the time period including the state of temporary blood flow cessation and the state of transitional blood flow. Optical non-invasive measurement of the concentration of at least one blood constituent are successively performed at these at least two sessions, and respective values of the concentration are obtained.

The invention discloses an intravascular multilayer bare stent system, and relates to the technical field of medical equipment. According to the technical points, a support body is composed of a firstframework and a second framework, and the first framework and the second framework are of a cylindrical net structure formed by weaving framework lines made of memory alloy or biodegradable polymer materials, overlapped with each other and opposite in spiral rotation direction. Rotary connecting rings are arranged at the upper sections, the middle sections and the lower sections of the first framework and the second framework; metal wires are connected to the inner wall of the rotary connecting ring; a hole-sealing strip-shaped film is connected to the side wall of the metal wire. The mesh sealing of the multilayer bare stent can be adjusted, so that the aneurysm cavity and the interlayer are isolated from normal blood flow, normal blood flow is prevented from leaking into the aneurysm cavity and the interlayer, blood flow in the aneurysm cavity and the interlayer is restrained, blood clots or thrombi are promoted to be formed in the aneurysm cavity and the interlayer to atrophy the aneurysm, the pressure in the aneurysm cavity is reduced, the potential risk that the aneurysm is increased and ruptured is reduced, and stable and guaranteed treatment purpose is achieved.

The invention belongs to the technical field of medical instrument implants, and particularly relates to a covering film type clamp for repairing the valve. The covering film type clamp comprises a first clamp body and a second clamp body, the first clamp body and the second clamp body conduct clamping to form a clamping tool, the clamping tool is provided with a covering film, the covering film comprises an inner layer covering film body and an outer layer covering film body, the inner layer covering film body wraps the clamping part of the clamping tool, and the outer layer covering film body wraps the outer surface of the clamping tool. By using the good blood compatibility of the inner layer covering film body and blood compatibility of good contact between the outer layer covering film body and the blood, forming of thromboses can be effectively reduced, and the performance of a normal blood flow biofluid environment is guaranteed.

A device comprising a single closed loop of elastic filament configurable between (i) a first configuration for movement along a blood vessel; and (ii) a second configuration for lodging within a blood vessel, the second configuration providing a single flow-restricting face sized and configured to cover the mouth of the aneurysm and obstruct blood flow to the aneurysm while permitting substantially normal blood flow through the blood vessel, with the degree of obstruction at the mouth of the aneurysm being such that the aneurysm thromboses when the face is positioned over the aneurysm, the flow-restricting face comprising a plurality of lengths of the closed loop of filament disposed in close proximity to one another in a switchback configuration, and at least one leg for holding the flow-restricting face adjacent the mouth of the aneurysm, the leg configured so as to maintain substantially normal blood flow through the blood vessel.

An apparatus to minimize and / or eliminate the effects associated with reperfusion injury consisting of an external pump, heat exchanger and control unit creating a flow loop whereby blood is moved from the body via a pump, cooled by an external heat exchanger and reintroduced into a specific location, thereby locally cooling the surrounding tissue and inducing localized hypothermia to minimize tissue injury resulting from ischemia and the effects associated with reperfusion injury as an obstruction is removed and normal blood flow is restored and including the ability to locally measure pressure and temperature in the body.

A cannulation system (10) for perfusing a patient's circulatory system, includes an inflow cannula (14) having a first end adapted to be connected to said circulatory system and a second end adapted to be connected to a blood pump (19), an outflow cannula (23) having a first end adapted to be connected to the blood pump (19) and a second end adapted to be connected to said circulatory system at a location downstream of the first end of the inflow cannula. The flow of blood from the pump (19) is in series with the normal blood flow of the circulatory system of the patient and creates a localised region of hypertension.

The invention discloses a vascular stent with absorbable films. The vascular stent comprises a tubular stent and a film unit. The tubular stent is of a flexible tubular structure and comprises a proximal end, a middle portion and a distal end which are sequentially arranged; the film unit is coated on the tubular stent; the film unit is made of degradable high-polymer materials. The vascular stenthas the advantages that the film unit can be absorbed by biological tissues, accordingly intimal hyperplasia and restenosis risks can be reduced, normal blood flow channels can be kept, and vascularstenosis can be effectively treated.

The invention discloses a driving circuit of a transistor and a pressure wave balloon angioplasty treatment system. The transistor controls a corresponding capacitor in the marx generator to perform parallel charging and series discharging, and the marx generator is applied to a high-voltage pulse power supply host in the pressure wave balloon angioplasty treatment system and used for treating andeliminating calcified plaques in a vascular wall so as to recover normal blood flow in a blood vessel; and the driving circuit comprises an isolation circuit and a main control circuit. When the maincontrol circuit receives an instruction of series discharge of the corresponding capacitor in the marx generator, the main control circuit sends out an instruction to control the isolation circuit tobe switched on. The isolation circuit receives a target electric signal when being conducted, and outputs a driving signal to a position between the gate and the source of the transistor, so that thetransistor is kept conducted. According to the driving circuit, when the capacitors of all levels in the marx generator are connected in series for discharging, the driving signal is output under thecondition that the gate-source voltage of each transistor floats, conduction of the transistors is maintained, and the stability and reliability during discharging of the marx generator are improved.

Method for sealing a stent graft in an endovascular aneurysm repair. Includes following steps / procedures. Positioning the stent graft to extend across an aneurysm in aneurysmatic host vessel. Introducing and placing a balloon catheter in the host vessel at a location distal to the graft distal end. Inflating balloon to pressure configured for unconstrained balloon expansion with maximal balloon diameter equal to or greater than smallest inner diameter of host vessel, thereby occluding normal blood flowing thereacross. Infusing contrast enhancing material through balloon catheter for allowing radiographic visualization of endoleakage between stent graft and a host vessel wall. Deflating and repositioning balloon to another location within stent graft. Pressurizing balloon to another pressure configured for plastically expanding selected section of stent graft from a smaller diameter to a fixed enlarged diameter.

Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroD1 to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroD1, wherein the nucleic acid encoding NeuroD1 is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroD1 such that NeuroD1 is expressed in a mammalian cell.

The disclosure is related to a system and method for operating a traction device to detect blood flow patterns in a subject for managing neuropathy related conditions through intraneural facilitation (INF). According to an embodiment, the INF system and method rely on the traction device for positioning the subject in one or more positions, and a processing device for processing intervening signals obtained by a probe positioned on the subject. The signals received from the probe may be used to determine a two dimensional (2D) plane blood flow pattern. Detected changes in the measured blood flow may be used to determine if further traction device positions are required to ensure that the intervening signals demonstrate normal blood flow patterns with improvements to the neuropathy condition. The 2D flow pattern may calculate at least one of Volume Flow (VF) and Pulsatility Index (PI) for each set of signals received.

The invention belongs to the technical field of orthopedic treatment, and in particular relates to an external traditional Chinese medicine composition for treating orthopedic diseases. The external traditional Chinese medicine composition comprises the following main components: 1-3 parts of borneol, 2-5 parts of radix angelicae sinensis, 4-6 parts of radix plygoni multiflori, 5-20 parts of radixclematidis, 5-10 parts of garden balsam stem, 10-15 parts of rhizoma paridis, 10-30 parts of semen strychni, 1-3 parts of musk, 1-3 parts of crab bone, 12-18 parts of rhizoma drynariae, 5-10 parts ofmyrrh, 2-5 parts of ant eggs, 1-3 parts of native copper, 100-150 parts of ethanol, and 15-35 parts of a medical pressure-sensitive adhesive. The external traditional Chinese medicine composition fortreating orthopedic diseases not only can effectively repair damaged bone joints and improve the repair speed, but also can reduce the pain of a patient, has the functions of promoting blood circulation and removing blood stasis, can effectively prevent extravasated blood caused by blood blockage, and reduces the influence on the normal blood flow.

The invention discloses a covered stent, which comprises a support structure and a tectorial membrane unit, and is characterized in that: the tectorial membrane unit comprises an inner-layer tectorial membrane and an outer-layer tectorial membrane which coats the support structure; the outer-layer membrane coats on the outer side of the inner-layer tectorial membrane; the inner-layer tectorial membrane is a biological membrane with good blood compatibility, and the outer-layer tectorial membrane is a biological membrane which is easy to induce the formation of thrombus; the inner-layer tectorial membrane contacting blood has good blood compatibility, can effectively reduce the formation of the thrombus, and maintains normal blood flowing channels; and the outer-layer tectorial membrane can induce the formation of the thrombus in aneurysm or thrombus of bleeding parts, promotes the aneurysm to be quickly activated and reduced, reduces the mass effect in vivo, simultaneously effectivelyadheres endothelial cells, promotes differentiation and proliferation of cells, quickens the endothelialization of lesion parts of vessels, and can more effectively treat vascular diseases such as the aneurysm and the like.

The invention discloses an ultrasonic blood detection method and device. The method comprises: adopting a high-frequency miniature linear array transducer with functions of beam deflection emission and beam synthesis emission to transmit ultrasonic waves and receive ultrasonic echo signals; The ultrasonic echo signal calculates the red blood cells in the blood of the test subject as the average spacing of the scattering elements, and compares it with the normal blood flow to evaluate the concentration of red blood cells in the blood of the test subject. The present invention utilizes the characteristics of deflection and emission of linear array transducers to realize accurate and effective measurement of blood flow velocity (macroscopic characteristics), utilizes the characteristics of beam forming of linear array transducers to improve the signal-to-noise ratio of echo signals, and utilizes high-frequency ultrasonic spatial resolution High characteristics realize the characterization (microscopic characteristics) of the average distance between red blood cells in blood, so as to deduce the change of blood concentration; two characteristics of flowing blood can be obtained at the same time: flow velocity and concentration, which provides more information for blood evaluation.

Provided is a guiding catheter inserted into the closest part of a target vessel to easily perform various operations when an intervention is operated in the vessel, and including a circular hole for blood circulation to secure normal blood flow of a target organ when a blood flow occlusion phenomenon due to reduction in inner diameter of the vessel occurs.

The invention belongs to the field of a medical care article, and particularly relates to a special auxiliary stent for an aneurysm liquid suppository. The special auxiliary stent comprises a stent body, a coating film and an opening, wherein the stent body is of a cylindrical tubular structure with openings at two ends; meshes are formed in the side wall of the cylindrical tubular structure; the coating film coats the side wall of the stent body; and the opening is formed in the coating film, and is used for passing a catheter used for injecting the liquid suppository. The special auxiliary stent for the aneurysm liquid suppository provided by the invention can well prevent the occurrence of reflux error thrombosis and superfluid error thrombosis; the normal blood of the human body cannot be blocked since a sealed saccule does not need to be used; and side effects caused by human tissue ischemia are avoided.

The invention relates to a device for an extracorporeal blood treatment, comprising a blood treatment unit (1) which has at least one compartment (4). The invention additionally relates to a method for determining a hemodynamic parameter during an extracorporeal blood treatment using an extracorporeal blood treatment device. In order to determine the hemodynamic parameter, the conveying directionof the blood pump (10) is reversed from a "normal" blood flow to a "reversed" blood flow. In practice, it has been shown that with a reversal of the flow direction of the blood pump for a measurementto detect a hemodynamic parameter, there is a risk that blood clots ends up in the patient even though the dialyzer retains blood clots. The blood treatment device has an input unit (23) for inputtinga time interval which the user can specify while taking into consideration the patient-specific and system-specific factors. The control and analysis unit (12) of the blood treatment device is configured such that the operation of the blood pump (10) in the operating mode with a reversed blood flow is released only within the time interval entered using the input unit, wherein the start of the time interval is determined by the time at which the blood treatment begins.