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39 results about "Genetic Change" patented technology

Genetic Change. The genetic code undergoes several changes during the process of evolution. However, despite such changes, there is preservation of the majority of characteristics of the species.

Use of chimeric nucleases to stimulate gene targeting

Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases.
Owner:CALIFORNIA INST OF TECH

Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer

InactiveUS7361474B2Aggressive diseaseAggressive treatmentMicrobiological testing/measurementPeptide preparation methodsSerum igeGenetic Change
The present invention provides methods for detecting, diagnosing or prognosticating prostate cancer by measuring the levels of macrophage migration inhibitory factor (MIF) in the serum of an individual. The assay for MIF can be an immunoassay, such as ELISA, or a nucleic assay, such as Nouthern blot. Genetic changes within MIF gene can predict patients that express high levels of MIF.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Blood test to monitor the genetic changes of progressive cancer using immunomagnetic enrichment and fluorescence in situ hybridization (FISH)

Amplification and overexpression of theHER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between the primary tumor and metastases. Therefore, patients with HER-2 negative primary tumors will rarely receive anti-HER-2 antibody therapy. A very sensitive blood test is used to capture circulating tumor cells (CTC's) and evaluate their HER-2 gene status by FISH evaluation. The HER-2 status of the primary tumor and corresponding CTC's is used to assess the ratio of CTC's as a reliable surrogate marker. HER-2 expression of 10 CTC's is sufficient to make a definitive diagnosis of the HER-2 gene status for the whole population of CTC's in patients with recurrent breast cancer.
Owner:JANSSEN DIAGNOSTICS LLC

Hepatocellular chimeraplasty

The present invention concerns compositions and methods for the introduction of specific genetic changes in endogenous genes of the cells of an animal. The genetic changes are effected by oligonucleotides or oligonucleotide derivatives and analogs, which are generally less than about 100 nucleotides in length. The invention provides for macromolecular carriers, optionally incorporating ligands for clathrin coated pit receptors. In one embodiment the ligand is a lactose or galactose and the genetic changes are made in hepatocytes. By means of the invention up to 40% of the copies of a target gene have been changed in vitro. Repair of mutant genes having a Crigler-Najjar like phenotype and Hemophilia B phenotype were observed.
Owner:ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV +1

Compositions and methods for diagnosing, evaluating and treating cancer

The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.
Owner:DANA FARBER CANCER INST INC +3

Methods and mechanisms involving hyperpigmentation particularly for african american skin

Sets of genes are identified that show modulated activity in hyperpigmented sun-exposed (HE) and non-hyperpigmented sun-exposed (NHE) skin, when compared to non-hyperpigmented non-exposed (NHNE) skin. The modulated sets of genes reveal important information about the genetic changes that take place in skin as a result of environmental exposure and damage. The modulated sets of genes may be used to fabricate custom DNA microarrays for evaluating patients with skin diseases or disorders. The microarrays may also be used to screen new substances for treating skin diseases and disorders. The modulated gene sets, and substances that target them, may also be used to develop therapies for individuals who suffer from hypopigmentation, such as those with Fitzpatrick type I skin or vitiligo.
Owner:HAMPTON UNIVERSITY

Vaccine composition

InactiveUS20060216307A1UpregulationReducing lipid A toxicityAntibacterial agentsSenses disorderProtective antigenBacteroides
The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
Owner:GLAXOSMITHKLINE BIOLOGICALS SA

Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer

The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR / CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and / or chemotherapy who may benefit from ATR / CHEK1 pathway inhibition, as well as methods of treating said patients.
Owner:UNIVERSITY OF PITTSBURGH

Metabolic evolution of escherichis coli strains that produce organic acids

This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
Owner:PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED

Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer

The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR / CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and / or chemotherapy who may benefit from ATR / CHEK1 pathway inhibition, as well as methods of treating said patients.
Owner:UNIVERSITY OF PITTSBURGH

Detection Panel and kit for pan-cancerous detection or targeted medication based on second generation sequencing and application

The invention discloses a detection Panel and kit for pan-cancerous detection or targeted medication based on second generation sequencing and application of the detection Panel and kit. The detectionPanel comprises a target gene region used for detecting pan-cancerous mutation burden and mutation sites related to targeted medication, and an exon region related to pan-cancerous mutation sites. According to the invention, a liquid (blood) biopsy method is adopted, and a combined determination method is used for carrying out genetic change and protein biomarkers; the detection Panel not only can identify the existence of relatively early cancers, but also can locate origin organs of the cancers, has higher sensitivity, can better carry out combined detection, and provides more accurate support for treatment diagnosis of targeting drugs, chemotherapeutic drugs or immune drugs; and by designing and integrating common areas of different mutation-type information, the uniformity of the Panel is improved, the overall data volume of the Panel is reduced, and the cost is reduced.
Owner:合肥诺为尔基因科技服务有限公司

Metabolic evolution of escherichia coli strains that produce organic acids

This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
Owner:PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED

Soil improvement material component for improving vegetable biomass

The invention relates to the technical field of vegetable planting, discloses a soil improvement material component for improving vegetable biomass, and aims to break through the current situation that vegetable biomass is improved through chemical fertilizer application or genetic change. The soil improvement material component comprises biochar and compost according to a mass ratio of the biochar to the compost of 1:0.3-2, wherein the biochar is prepared by crushing garden plant branches and calcining the crushed branches at a low temperature in an anoxic environment, the garden plant branches are soaked in a sodium bicarbonate solution before preparation, and the compost is prepared by mixing branches of arbors and shrubs as a compost material with nitrogen, stacking and fermenting. Thesoil improvement material component provided by the invention can effectively improve the vegetable biomass and reasonably utilize garden plant wastes.
Owner:HANGZHOU BOTANICAL GARDEN

Use of mixed duplex oligonucleotides to effect localized genetic changes in plants

The invention concerns the use of duplex oligonucleotides about 25 to 30 base pairs to introduce site specific genetic alterations in plant cells. The oligonucleotides can be delivered by mechanical (biolistic) systems or by electroporation of plant protoplasts. Thereafter plants having the genetic alteration can be generated form the altered cells. In specific embodiments the invention concerns the alteration in the gene that encode acid invertase, UDP-glucose pyrophosphorylase, polyphenol oxidase, O-methyl transferase, cinnamyl alcohol dehydrogenase, ACC synthase and ACC oxidase or etr-1 or homolog of etr-1, and plants having isolated point mutations in such genes.
Owner:ARNTZEN CHARLES +3

Compositions and methods for transferring biomolecules to wounded cells

The invention provides novel methods and compositions for introduction, transfer or delivery of one or more biomolecules into wounded recipient plant cell(s). Methods for production of a wounded recipient cell culture and the creation of one or more mutations, edits, transgenic insertions, or other genetic changes in the recipient cell(s) are also provided. Product cells produced by such methods, and resulting cells and regenerated plants, plant parts, and progeny plants are further provided. Molecular and genetic analyses, analysis of phenotypes and traits, and use of screenable and selection markers, are also provided to confirm transfer of the biomolecule in to the recipient cell(s) and generation of the mutation, edit, transgenic insertion, or other genetic change in the recipient cell(s), and / or progeny thereof, and in plants or plant parts developed or regenerated from the foregoing.
Owner:MONSANTO TECH LLC

Use of Transcriptome Modifying Agents and Chemotherapy or Radiotherapy Against Cancer

The use of transcriptome-modifying agents is disclosed in order to prevent malignant cells from undergoing the necessary genetic changes in order to combat cell insult and survive chemotherapy or radiotherapy. The combination of transcriptome-modifying agents comprises agents that inhibit the DNA methylation machinery plus a substance that inhibits histone deacetylation. A treatment kit is disclosed which includes an effective dose of hydralazine and valproic acid or a salt of same in the case of magnesium valproate, which is intended for use with radiotherapy or chemotherapy in the treatment of patients cancer.
Owner:UNIV NAT AUTONOMA DE MEXICO

Method and apparatus for assessing patient response to treatment

The invention relates to monitoring a patient's response to treatment. To facilitate monitoring a patient's response to a treatment, the invention provides a method to identify a set of trends in each of the genetic changes having similar genetic changes over time, and to analyze the sets to determine a patient's response to a treatment.
Owner:KONINKLJIJKE PHILIPS NV

Cutting propagation method for coniferous trees

The invention belongs to the technical field of vegetative propagation of plants and particularly relates to a cutting propagation method for needle-leaved trees. Preferentially, the needle-leaved trees are Torreya jackii Chun. The method particularly comprises steps as follows: (1) building of full-sunshine automatic spraying and cutting pool; (2) collecting and processing of cuttings; (3) cutting; (4) culture management after cutting; (5) management after transplanting. The method is simple and easy to implement, the propagation survival rate is high, the genetic change is small, management is convenient, large-scale propagation is facilitated, endangered plant, namely, Torreya jackii Chun can be effectively saved, and the survival environment of the species evolves to the north.
Owner:徐州市贾汪区瓦庄生态农业科技发展有限公司

Probes and a methylation in situ hybridization assay

The disclosure relates to the field of molecular pathology (for example, cancer diagnosis, prognosis, treatment and / or therapy prediction) through the detection of RNA, mutations, copy number changes and determination of the methylation status of specific sequences of the genome of individual patients in hybridization assays (southern blot, ISH, dot blot) including in situ determination of the methylation status of specific sequences of the genome of individual patients in individual cells. More specifically, this disclosure relates to: a) target-specific probes covalently attached to a labeled tail, b) the synthesis method of said the probe, c) the usage of said the probe such as an in situ hybridization-based method to correlate the methylation status of a promoter region of a gene in a biopsy or cytology specimen of a patient to the morphology and localization in that specimen, and d) kits comprising the target-specific probes. The latter method and products allow detection of (epi) genetic changes in specific cell types of histological or cytological (cancer) specimens or on membranes that will contribute to scientific research and that will help physicians to accurately diagnose diseases and / or start an appropriate treatment.
Owner:UNIV GENT

Method for extracting total RNA from hemolymph of procambarus clarkii

The invention belongs to the technical field of preparation technology of RNA samples from aquatic animals, and specifically relates to a method for extracting total RNA from hemolymph of procambarusclarkii. The method includes two main steps of extracting the hemolymph of procambarus clarkii and separating blood cells and extracting the total RNA from the hemolymph samples. The extraction of thetotal RNA can be completed with only a small amount of hemolymph, so that the procambarus clarkii can be still alive after blood drawing, and the observation and study on the genetic changes in the bodies of the procambarus clarkii can be continuously carried out. The extracted total RNA is excellent in quality and little in degradation and can be used for high-throughput sequencing; and the method is low in cost, simple in operation and stable in extraction effect, and can guarantee the activity of the procambarus clarkii while extracting the total RNA from the hemolymph.
Owner:HUAZHONG AGRI UNIV
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