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201 results about "Receptor molecule" patented technology

Receptor Definition. A receptor is a protein which binds to a specific molecule. The molecule it binds is known as the ligand. A ligand may be any molecule, from inorganic minerals to organism -created proteins, hormones, and neurotransmitters. The ligand binds to the ligand-binding site on the receptor protein.

Microelectronic device and method for label-free detection and quantification of biological and chemical molecules

Molecular recognition-based electronic sensor, which is gateless, depletion mode field effect transistor consisting of source and drain diffusions, a depletion-mode implant, and insulating layer chemically modified by immobilized molecular receptors that enables miniaturized label-free molecular detection amenable to high-density array formats. The conductivity of the active channel modulates current flow through the active channel when a voltage is applied between the source and drain diffusions. The conductivity of the active channel is determined by the potential of the sample solution in which the device is immersed and the device-solution interfacial capacitance. The conductivity of the active channel modulates current flow through the active channel when a voltage is applied between the source and drain diffusions. The interfacial capacitance is determined by the extent of occupancy of the immobilized receptor molecules by target molecules. Target molecules can be either charged or uncharged. Change in interfacial capacitance upon target molecule binding results in modulation of an externally supplied current through the channel.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

System, device and method for determining the concentration of an analyte

There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and / or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa). As such, some or all (or substantially all) of the receptor molecules within a given layer may bind with the analyte, which results in a change in the optical properties of one or more of the layers. These layer(s) may be examined or interrogated, via optical techniques, whereby the optical response of the layers and / or, in particular, the substance within the layer(s), may be measured, evaluated and / or analyzed.
Owner:BIO TEX LTD INC

Microelectronic device and method for label-free detection and quantification of biological and chemical molecules

InactiveUS20020012937A1Wide scope of practicalWide scope of worthwhile utilizationBioreactor/fermenter combinationsBiological substance pretreatmentsCapacitanceField-effect transistor
Molecular recognition-based electronic sensor, which is gateless, depletion mode field effect transistor consisting of source and drain diffusions, a depletion-mode implant, and insulating layer chemically modified by immobilized molecular receptors that enables miniaturized label-free molecular detection amenable to high-density array formats. The conductivity of the active channel modulates current flow through the active channel when a voltage is applied between the source and drain diffusions. The conductivity of the active channel is determined by the potential of the sample solution in which the device is immersed and the device-solution interfacial capacitance. The conductivity of the active channel modulates current flow through the active channel when a voltage is applied between the source and drain diffusions. The interfacial capacitance is determined by the extent of occupancy of the immobilized receptor molecules by target molecules. Target molecules can be either charged or uncharged. Change in interfacial capacitance upon target molecule binding results in modulation of an externally supplied current through the channel.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

Emission ratiometric indicators of phosphorylation by C-kinase

InactiveUS20050026234A1Facilitate its translocationPeptide/protein ingredientsAntibody mimetics/scaffoldsNucleotideFluorophore
A chimeric phosphorylation indicator (CPI) as provided herein can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. Where the phosphorylatable domain is phosphorylatable by protein kinase C (PKC), the CPI is a c-kinase activity reporter (CKAR). Donor and acceptor molecules may be, independently, fluorescent proteins such as non-oligomerizing fluorescent proteins. A CPI can contain a phosphorylatable polypeptide and a fluorescent protein; the phosphorylatable polypeptide may be contained within the sequence of the fluorescent protein, or the fluorescent protein may be contained within the sequence of the phosphorylatable polypeptide. The spatiotemporal properties of the PKC signal pathway may be tested with CKAR, calcium-sensing fluorophores and FRET-based translocation assays. Polynucleotides encoding such CPIs, and kits containing the indicators and / or the polynucleotides, are provided. A method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.
Owner:RGT UNIV OF CALIFORNIA +1

Fermentative production of acetone from renewable resources by means of novel metabolic pathway

The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalysed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase.A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
Owner:EVONIK OPERATIONS GMBH

Naphthyl-based phenazine receptor molecule, test paper and synthesis thereof, and application of receptor molecule in identification of Fe<3+> and H2PO4<->

The invention relates to a synthesis method of a receptor molecule used for identifying H2PO4<-> and Fe<3+>. The receptor molecule treats a naphthalene ring as a fluorescence signal report group, uses an oxygen atom in a hydroxy group and nitrogen atoms in an imidazolyl group as binding sites of Fe<3+>, and has a strong complexing ability on Fe<3+>, H2PO4<-> and Fe<3+> can form Fe(H2PO4)3 inorganic salt, so Fe<3+> and H2PO4<-> can be continuously fluorescently identified. Results of fluorescence titration experiments show that the receptor has a high detection sensitivity to each of Fe<3+> and H2PO4<->, and the lowest detectable limits reach 0.29ppm and 0.19ppm respectively. The invention also relates to a receptor molecule supported colorimetric test paper. The colorimetric test paper can conveniently and fast fluorescently detect Fe<3+> and H2PO4<->, and has a very good application prospect in the detection fields of Fe<3+> and H2PO4<->.
Owner:NORTHWEST NORMAL UNIVERSITY
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