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35results about How to "Improve learning and memory impairment" patented technology

Tubiflorous desert cistanche prepn containing phenethyl alcohol glycoside and its prepn process and use

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.
Owner:JIANGSU KANION PHARMA CO LTD

Scorpion venom heat-resisting polypeptide, and preparing method and applications thereof

InactiveCN104341495AGood effectDefine pharmacodynamic activity and pharmacodynamic targetsNervous disorderPeptide/protein ingredientsDiseaseMedicine
The invention provides a scorpion venom heat-resisting polypeptide, and a preparing method and applications thereof, and belongs to the field of polypeptide and preparation thereof. The scorpion venom heat-resisting polypeptide which is safer is obtained by removing heat-resisting and heat-labile toxic components mainly from the scorpion venom of buthus martensii kirsch (BmK). The polypeptide is used for preventing and treating intractable epilepsy, Parkinson's disease (PD), Alzheimer's disease (AD), and other diseases, has a common function target, and has respective special medicine effects. Preparation of the polypeptide is stable in process, simple and controllable.
Owner:张万琴

Chinese medicine preparation for treating senile dementia and preparation thereof

A Chinese medicine for treating senile dementia, dizziness, disturbed sleep, etc is prepared from fleece flower root, lotus leaf, cistanche, earthworm and uniflower swisscentaury root through respective extracting, and proportional mixing.
Owner:安徽雷允上药业有限公司

Method for preparing shiny-leaved yellowhorn total saponins and application of shiny-leaved yellowhorn total saponins

The invention belongs to the technical field of medicines, and relates to a novel method for preparing shiny-leaved yellowhorn total saponins from shiny-leaved yellowhorn and an application of the shiny-leaved yellowhorn total saponins. According to the method, a coarse extract of the shiny-leaved yellowhorn is directly separated and purified by a macroporous resin method to obtain shiny-leaved yellowhorn total saponins; the yield of the total saponins is over 5 percent, and the content of the total saponins in a product is over 60 percent and far higher than that in products prepared by other processes. The prepared shiny-leaved yellowhorn total saponins can be applied to preparation of medicines or health-care products for preventing and treating memory deterioration, hypophrenia and cranial nerve injury caused by neurodegenerative diseases and acute and chronic cerebral injury diseases, and can be used for treating cerebral diseases caused by alzheimer disease, acute disease and subacute stage of cerebral arterial thrombosis, vascular dementia and other ischemia and hypoxia of neurodegenerative diseases and acute and chronic cerebral injury diseases.
Owner:SHENYANG PHARMA UNIVERSITY

ShRNA (Short Hairpin Ribonucleic Acid) kit for treating animal model suffered from alzheimer disease

The invention relates to a shRNA (Short Hairpin Ribonucleic Acid) kit for treating an animal model suffered from an alzheimer disease. The kit internally comprises shRAN slow virus expression plasmid vector concentrated liquor capable of specifically suppressing a caspase-3 gene, and shRAN slow virus expression plasmid vector concentrated liquor as negative control, wherein the shRAN comprises sequences of SEQ ID No.1 and SEQ ID NO.2 in a sequence table. Compared with other means, the shRAN sequence or a reagent obtained therefrom can specifically and conveniently suppress the expression of disease-related proteins at high efficiency when entering the body of the animal model in a certain manner and lead disease-related genes to be silent, thereby achieving the treatment purpose; and therefore, the kit provided by the invention can be used for gene therapy for the animal model suffered from the alzheimer diseases.
Owner:SHANXI MEDICAL UNIV

Puerarin derivative and synthetic method and application thereof

A puerarin derivative and a synthetic method and an application thereof belong to the field of cerebrovascular diseases. Selectivity of a vascular dementia therapeutic target is improved by decorating puerarin. The puerarin derivative is indicated through a formula (1) which is as follows. By means of a chemical synthetic method, products are applied to treatment of vascular dementia. Fat solubility and water solubility of the puerarin are improved, receptor selectivity of the puerarin is improved, osmotic pressures inside and outside brain cells are balanced, cellular swelling caused by inflammatory injury is improved, a pharmacologic action of the puerarin itself of improving microcirculation and cholinergic nerve system functions is highlighted, and learning and memory disorders caused by damage caused by ischemia reperfusion are avoided.
Owner:HARBIN UNIV OF COMMERCE

Application of curcumin in preparing medicine for treating IIIV-1 relevant cognitive disorder

The present invention provides the application of curcumin in preparing medicine for treating HIV-1 relevant cognitive disorder. Curcumin may be used in preparing medicine for treating HIV-1 relevant cognitive disorder alone or through combination with other memory improving medicine. Experiment shows that curcumin can improve the memory capacity of rat with memory disorder caused by HIV-1gp120, with curcumin in low dosage (50 mg / kg) possessing higher effect.
Owner:JINAN UNIVERSITY

Medicine for treating alzheimer's disease

InactiveCN101120946AReduce the number of age spotsReduced tau protein levelsOrganic active ingredientsNervous disorderEvodiamineActive component
The present invention provides a medicine for presenile dementia treatment, which takes dehydrogenation evodiamine as the active component. Studies proves that the dehydrogenation evodiamine has an inhibiting effect in notable pathological change of presenile dementia patients, which can not only reduce the senile plaque quantity of the presenile dementia, but also can reduce the phosphorylation tau protein level, therefore learning and memory impairment are dramatically improved. The medicine is an effective medicine for presenile dementia prevention and treatment.
Owner:HUAZHONG UNIV OF SCI & TECH

Application of pseudobulubs cremastrae seu pleiones' effective part in treatment of senile dementia

The invention relates to an effective part extracted from the traditional Chinese medicine pseudobulubs cremastrae seu pleiones (with plant root in Pleione bulbocodioides and Pleione yunnanensis), a preparation method, and application thereof in treatment of senile dementia and vascular dementia. Animal tests prove that the effective part can obviously improve the learning and memory disorder of scopolamine induced mouse cholinergic impairment analog dementia animal models, can enhance the recognition capability of common carotid artery ligation induced vascular dementia rats on new objects, and can improve the object recognition disorder and spatial learning and memory disorder caused by vascular dementia. With antioxidant capacity, the pseudobulubs cremastrae seu pleiones' effective part can reach the effect of delaying degenerative changes of nerve cells by reducing oxidative damage response.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI

TAT-LBD-PEP fusion protein and application of TAT-LBD-PEP fusion protein in treatment of central nervous system lesion

InactiveCN103130898ASolve the problem of not being able to penetrate the blood-brain barrierImprove targetingNervous disorderPeptide/protein ingredientsNervous systemMyelin
The invention discloses TAT-LBD-PEP fusion protein and application of the TAT-LBD-PEP fusion protein in treatment of central nervous system lesion. The TAT-LBD-PEP fusion protein is combined with myelin inhibiting factors MAG, Nogo-66 and OMgp, accordingly the axon regenerative capacity is promoted through antagonism PirB effect, and the TAT-LBD-PEP fusion protein has the advantages of being high transduction efficiency and easily transmitting a blood-spinal barrier and a blood brain barrier, can transduce targeting to a hurt region and has the enrichment effect on an ischemic region. The problems that additional harm of nervous tissues is caused by the protein injection in a micro-injection mode or other injection modes and macromolecule cannot transmit the blood-spinal barrier and the blood brain barrier are solved, and the shortcoming that corresponding biological concentration cannot be met is overcome, and the targeting is transduced to the ischemic region through a ligand binding domain (LBD). The TAT-LBD-PEP fusion protein can be prepared in large-scale mode, is low in cost and high in activity, and is used for treatment of various brain and spinal cord injury including cerebral ischemia hypoxia, cerebral hemorrhage, cerebral trauma, spinal cord injury and the like and promoting regeneration of nervous tissues and neural functional recovery.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Composition for preventing and/or delaying old people with mild cognitive impairment and use method thereof

InactiveCN106389740APrevention and/or delay of mild cognitive impairmentEasy to solveOrganic active ingredientsNervous disorderDiseaseCannabis
The invention discloses a composition for preventing and / or delaying old people with mild cognitive impairment and a use method thereof; the composition comprises the following components in parts by weight: 3000-6000 parts of a coffee powder, 0.2-0.4 part of folic acid, 15000-30000 parts of coconut oil, 15000-30000 parts of semen cannabis, and 3-5 parts of melatonin, wherein the coffee powder contains 3.6-4.2 wt% of caffeine. The composition can improve the antioxidant capacity of brain tissues and prevents the brain tissues from being damaged by free radicals. Animal experiments indicate that the composition can effectively improve learning and memory impairment in Alzheimer's disease model mice; human body test-meal experiments indicate that the old people with mild cognitive impairment take the composition at a specific point in time, and have a significant improving effect on memory improvement. With regular effective taking of the composition, the old people with mild cognitive impairment can be prevented from suffering from Alzheimer's disease, or the incidence time can be delayed.
Owner:王全峰

Umbilical cord mesenchymal stem cell modified by Nrf2 gene as well as preparation method and application thereof

The invention relates to the technical field of stem cells, in particular to umbilical cord mesenchymal stem cell modified by a Nrf2 gene as well as a preparation method and an application thereof. The invention discloses the umbilical cord mesenchymal stem cell modified by the Nrf2 gene. The umbilical cord mesenchymal stem cell modified by the Nrf2 gene is the umbilical cord mesenchymal stem cellfor overexpression of the Nrf2. The resistance of the Nfr2 gene modified UCMSC to nerve injury is enhanced, the oxidative stress can be effectively antagonized, and the Nfr2 gene modified UCMSC can effectively promote the UCMSC to be converted into neural stem cells compared with the unmodified UCMSC. The UCMSC modified by the Nfr2 gene is transplanted into a dementia mouse body; the Nfr2 gene modified UCMSC can significantly improve learning and memory impairment of dementia mice, protect oxidative damage of brain tissues of the dementia mice, reduce activity of hippocampus AChE and NO in the brains of the dementia mice and inhibit release of inflammatory factors in the hippocampus tissues in the brains of the senile dementia mice. The technical support is provided for preparing a medicine for treating senile dementia by the stem cell.
Owner:李陶 +1

Traditional Chinese medicine composition for preventing and treating vascular dementia

The invention discloses a traditional Chinese medicine composition for preventing and treating vascular dementia. The traditional Chinese medicine composition for preventing and treating vascular dementia comprises ginseng, gastrodia elata, Euonymus alatus and Ligusticum wallichii. The composition can be prepared into Chinese herbal preparation crude drug for preventing and treating vascular dementia. The ginseng and the Ligusticum wallichii are extracted with alcohol, the gastrodia elata and the Euonymus alatus are extracted with water, the obtained alcohol extract and the obtained water extract are mixed, the mixture is dried under vacuum and then is pulverized to obtain the final product, and the composition can be directly taken orally or is prepared into other dosage forms such as granules, capsules, soft capsules, electuaries, pills and decocted extracts. The composition is completely prepared from natural medicinal plants, does not contain hormones, and does not contain other chemical synthetic products such as pigment, and even if a patient orally takes the composition continuously, no toxic and side effect is performed on the human body. The traditional Chinese medicine composition contains various easily absorbable ingredients such as ginsenoside, chuanxiongol, chuanxiongzine, gastrodin and quercetin, can be effectively used for treating the vascular dementia, increases cerebral blood flow, reduces cerebral vascular resistance, improves body immunocompetence, and has effects of tonifying deficiency, promoting intelligence, suppressing the hyperactive liver, subsiding Yang, dispelling blood stasis and dredging collaterals.
Owner:XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI

Folium cortex eucommiae effective position, and preparation method and application thereof

The invention relates to a preparation method of a folium cortex eucommiae effective position. The method comprises the following steps of performing ultrasound or scattered extraction on crushed folium cortex eucommiae by 30 to 80-percent ethyl alcohol; after the extraction liquid concentration, performing adsorption by macroporous adsorption resin; then, sequentially performing water washing, 20-60-percent ethyl alcohol gradient elution; merging elution liquid collected in gradient elution; performing concentration and drying to obtain the folium cortex eucommiae effective position. Through experiments, the folium cortex eucommiae effective position has the obvious protection effect on the mouse brain nerve DNA injury induced by alcohol; through the protection mechanism, the anti-oxidization function of the mouse brain tissues can be enhanced; the body is protected from further injury by free radicals; the folium cortex eucommiae effective position can be used for preparing brain nerve protection health care products, food or medicine.
Owner:HENAN UNIVERSITY

Medicinal composite for treating Alzheimer's disease

The invention discloses a medicinal composite for treating Alzheimer's disease. The medicinal composite for treating the Alzheimer's disease comprises procyanidine and cysteine, wherein the mass ratio of the procyanidine to the cysteine is (0.1-10):1, preferably (1-3):1; and the procyanidine is preferably lotus procyanidine. The medicinal composite for treating the Alzheimer's disease can improve the oxidation resistance of brain tissue, avoid free radical injury to the brain tissue, inhibit MAO-B and AchE activity and enhance the oxidation resistance of brain and hippocampal anti-oxidation system and serum so as to improve the learning and memory function. According to animal tests, the medicinal composite for treating the Alzheimer's disease can effectively improve mouse learning and memory injury induced by ethanol and scopolamine, and the curative effect is more excellent than that of piracetam and procyanidine.
Owner:HUAZHONG AGRICULTURAL UNIVERSITY

The use of new cornus glycosides in the preparation of medicaments for the treatment of Alzheimer's disease

The invention relates to a new application of split iridoid derivatives in the field of pharmacy, in particular to the application of split ring iridoid derivatives in the preparation of drugs for preventing and treating neurodegenerative diseases. In the treatment of neurodegenerative diseases, this type of product can significantly increase the activity of nerve cells and exert an obvious neuroprotective effect. The protective effect on the SH‑SY5Y cell model damaged by hydrogen peroxide is stronger than that of loganin, Morroniside can significantly improve the learning and memory impairment of aging individuals, and significantly increase the total antioxidant capacity in brain tissue.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

A kind of preparation method and application of total saponins of Xingguan fruit

The invention belongs to the technical field of medicines, and relates to a novel method for preparing shiny-leaved yellowhorn total saponins from shiny-leaved yellowhorn and an application of the shiny-leaved yellowhorn total saponins. According to the method, a coarse extract of the shiny-leaved yellowhorn is directly separated and purified by a macroporous resin method to obtain shiny-leaved yellowhorn total saponins; the yield of the total saponins is over 5 percent, and the content of the total saponins in a product is over 60 percent and far higher than that in products prepared by other processes. The prepared shiny-leaved yellowhorn total saponins can be applied to preparation of medicines or health-care products for preventing and treating memory deterioration, hypophrenia and cranial nerve injury caused by neurodegenerative diseases and acute and chronic cerebral injury diseases, and can be used for treating cerebral diseases caused by alzheimer disease, acute disease and subacute stage of cerebral arterial thrombosis, vascular dementia and other ischemia and hypoxia of neurodegenerative diseases and acute and chronic cerebral injury diseases.
Owner:SHENYANG PHARMA UNIVERSITY

Puerarin derivatives and their synthetic methods and applications

A puerarin derivative and a synthetic method and an application thereof belong to the field of cerebrovascular diseases. Selectivity of a vascular dementia therapeutic target is improved by decorating puerarin. The puerarin derivative is indicated through a formula (1) which is as follows. By means of a chemical synthetic method, products are applied to treatment of vascular dementia. Fat solubility and water solubility of the puerarin are improved, receptor selectivity of the puerarin is improved, osmotic pressures inside and outside brain cells are balanced, cellular swelling caused by inflammatory injury is improved, a pharmacologic action of the puerarin itself of improving microcirculation and cholinergic nerve system functions is highlighted, and learning and memory disorders caused by damage caused by ischemia reperfusion are avoided.
Owner:HARBIN UNIV OF COMMERCE

A traditional Chinese medicine composition for improving memory and mild cognitive impairment and preparation method thereof

The invention provides a traditional Chinese medicine composition for improving memory and mild cognitive impairment. The traditional Chinese medicine composition comprises 40-80 parts of thinleaf milkwort root-bark, 40-80 parts of grass leaf sweetflag rhizome, 40-80 parts of ginseng, 80-120 parts of tall gastrodia tuber, 80-120 parts of papermulberry fruit, 80-120 parts of ginkgo leaves and 0.01-3 parts of borneol. The traditional Chinese medicine composition can achieve the effects of obviously increasing the number density and surface density of synapse of the molecular layer of mouse hippocampal CA1, obviously enhancing the SOD activities of central cerebral cortex and hippocampus, reducing the content of lipofuscin of the neuron, obviously improving the learning and memory impairment of spontaneous senile dementia model mice, obviously enhancing the activity and fiber density of NOS1 of the central cerebral cortex and hippocampus and obviously up-regulating the contents of SS, AVP and ACTH of the cerebral cortex and hippocampus, especially the content of SS. The traditional Chinese medicine composition can achieve the effect of obviously improving the clinical symptoms of memory and cognitive impairment and has definite curative effects and great application prospects.
Owner:深圳市锦泰医药科技合伙企业有限合伙 +1

Imino-urea derivatives

The present invention relates to the field of medicines, and in particular to an imino-urea derivative containing a furan structure and a composition thereof. The derivative and the composition thereof can be used in the manufacture of a medicament for treating a disease pathologically characterized by indoleamine 2,3-dioxygenase-mediated tryptophan metabolic pathway. The present invention also relates to a method for preparing the derivative and an intermediate thereof.
Owner:LUNAN PHARMA GROUP CORPORATION

Application of rhizoma bletillae active part in treating senile dementia

The invention relates to an active part extracted from Chinese herb rhizome bletillae, a preparation method of the active part and an application of the active part in treating Alzheimer's disease (AD) and vascular dementia (VD). The animal test shows that the active part can apparently improve the memory acquisition disorder of cholinergic injury imitative dementia mouse caused by scopolamine, can improve the spatial learning and memory disorder of AD mouse caused by intracerebroventricular injection of Abeta and the spatial learning and memory disorder of the VD mouse caused by bilateral cervical general artery permanent ligation, and has an effect for apparently improving the animal learning memory disorder.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI

A kind of traditional Chinese medicine composition for preventing and treating vascular dementia

The invention discloses a traditional Chinese medicine composition for preventing and treating vascular dementia. The traditional Chinese medicine composition for preventing and treating vascular dementia comprises ginseng, gastrodia elata, Euonymus alatus and Ligusticum wallichii. The composition can be prepared into Chinese herbal preparation crude drug for preventing and treating vascular dementia. The ginseng and the Ligusticum wallichii are extracted with alcohol, the gastrodia elata and the Euonymus alatus are extracted with water, the obtained alcohol extract and the obtained water extract are mixed, the mixture is dried under vacuum and then is pulverized to obtain the final product, and the composition can be directly taken orally or is prepared into other dosage forms such as granules, capsules, soft capsules, electuaries, pills and decocted extracts. The composition is completely prepared from natural medicinal plants, does not contain hormones, and does not contain other chemical synthetic products such as pigment, and even if a patient orally takes the composition continuously, no toxic and side effect is performed on the human body. The traditional Chinese medicine composition contains various easily absorbable ingredients such as ginsenoside, chuanxiongol, chuanxiongzine, gastrodin and quercetin, can be effectively used for treating the vascular dementia, increases cerebral blood flow, reduces cerebral vascular resistance, improves body immunocompetence, and has effects of tonifying deficiency, promoting intelligence, suppressing the hyperactive liver, subsiding Yang, dispelling blood stasis and dredging collaterals.
Owner:XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI

TAT-LBD-PEP fusion protein and application of TAT-LBD-PEP fusion protein in treatment of central nervous system lesion

The invention discloses TAT-LBD-PEP fusion protein and application of the TAT-LBD-PEP fusion protein in treatment of central nervous system lesion. The TAT-LBD-PEP fusion protein is combined with myelin inhibiting factors MAG, Nogo-66 and OMgp, accordingly the axon regenerative capacity is promoted through antagonism PirB effect, and the TAT-LBD-PEP fusion protein has the advantages of being high transduction efficiency and easily transmitting a blood-spinal barrier and a blood brain barrier, can transduce targeting to a hurt region and has the enrichment effect on an ischemic region. The problems that additional harm of nervous tissues is caused by the protein injection in a micro-injection mode or other injection modes and macromolecule cannot transmit the blood-spinal barrier and the blood brain barrier are solved, and the shortcoming that corresponding biological concentration cannot be met is overcome, and the targeting is transduced to the ischemic region through a ligand binding domain (LBD). The TAT-LBD-PEP fusion protein can be prepared in large-scale mode, is low in cost and high in activity, and is used for treatment of various brain and spinal cord injury including cerebral ischemia hypoxia, cerebral hemorrhage, cerebral trauma, spinal cord injury and the like and promoting regeneration of nervous tissues and neural functional recovery.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
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