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Application of white and effective parts in the treatment of senile dementia

An effective part and technology of vascular dementia, which is applied in the field of prevention and treatment of Alzheimer's disease and vascular dementia, and can solve problems such as side effects, limited therapeutic effect, and single effect of senile dementia

Active Publication Date: 2021-07-06
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned drug treatment senile dementia effect is single, and therapeutic effect is limited, has certain side effect

Method used

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  • Application of white and effective parts in the treatment of senile dementia
  • Application of white and effective parts in the treatment of senile dementia
  • Application of white and effective parts in the treatment of senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 extraction method

[0029] Add 100g of medicinal materials, add water to soak, extract by percolation, use 3 liters, combine percolation liquid, recover water under reduced pressure, concentrate, filter to obtain extract 1, dry to obtain sample 1 (A).

[0030] 100g of medicinal materials, add 15 times the amount of 75% ethanol to soak, extract by dipping three times, each time for 1.0 hour, combine the extracts, extract the ethanol under reduced pressure until there is no alcohol smell, concentrate, filter to obtain extract 2, dry, and obtain Sample 2(B).

[0031] 100g of medicinal material is soaked in 12 times the amount of 95% ethanol, heated and refluxed for three times, each time for 1.0 hour. Combine the extracts, recover the ethanol from the extracts under reduced pressure until there is no alcohol smell, concentrate, filter to obtain extract 3, and dry to obtain sample 3 (C).

Embodiment 2

[0032] Example 2 Purification method 1-reverse phase silica gel chromatography

[0033] The extract 2 in Example 1, the solvent was recovered under reduced pressure and concentrated to a liquid extract, and the above-mentioned concentrated extract was mixed with reversed-phase silica gel or diatomaceous earth (the ratio of sample to reversed-phase silica gel was 1:2.5), reversed-phase Purified by silica gel chromatography (the ratio of sample to reverse-phase silica gel is 1:80), eluted with water, 10% ethanol and 30% ethanol solvent, 50% ethanol eluted, recovered solvent under reduced pressure, filtered, dried, white and effective Site 1 (T-1).

Embodiment 3

[0034] Embodiment 3 refining method 2-solvent extraction method

[0035] Extract 2 in Example 1, the solvent was recovered under reduced pressure, filtered, the filtrate was extracted with ethyl acetate (volume ratio 1:1), and then extracted 5 times with n-butanol (volume ratio 1:1), filtered, and dried. Debai and effective part 2 (T-2).

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Abstract

The present invention relates to the effective part extracted from the traditional Chinese medicine Baiji, its preparation method and its use in treating Alzheimer's Disease (AD) and vascular dementia (VD). It has been confirmed by animal experiments that this effective part can significantly improve the memory acquisition impairment of scopolamine-induced cholinergic impairment in dementia mice; improve the space of AD rats induced by intracerebroventricular injection of Aβ and VD rats induced by permanent ligation of bilateral common carotid arteries. Learning and memory impairment has obvious improvement effect on animal learning and memory impairment.

Description

Technical field: [0001] The present invention relates to the effective part extracted from the traditional Chinese medicine Baiji, the preparation method of the effective part, the pharmaceutical composition containing the effective part, and the effective parts containing the effective part and the pharmaceutical composition in the prevention and treatment of Alzheimer's disease. Dementia disease (AD) and vascular dementia (VD). Background technique: [0002] With the development of society, the prolongation of human life span and the increasingly serious phenomenon of social aging, the prevalence of senile dementia has increased significantly, and it has become the fourth leading cause of death. Senile dementia mainly includes Alzheimer's disease (Alzheimer's Disease, AD) and vascular dementia (Vascular dementia, VD). Alzheimer's disease is a progressive neurodegenerative disease, mainly manifested as neuropsychiatric symptoms such as progressive memory impairment, cognit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P25/28
CPCA61K36/898A61K2236/331A61K2236/333A61K2236/55
Inventor 李帅张建军石建功徐瑞明韩少伟
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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