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Application of rhizoma bletillae active part in treating senile dementia

An effective part and technology of vascular dementia, which is applied in the field of prevention and treatment of Alzheimer's disease and vascular dementia, and can solve the problems of single effect, side effects and limited therapeutic effect of senile dementia

Active Publication Date: 2017-08-29
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned drug treatment senile dementia effect is single, and therapeutic effect is limited, has certain side effect

Method used

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  • Application of rhizoma bletillae active part in treating senile dementia
  • Application of rhizoma bletillae active part in treating senile dementia
  • Application of rhizoma bletillae active part in treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 extraction method

[0029] Add 100g of medicinal materials, add water to soak, extract by percolation, use 3 liters, combine percolation liquid, recover water under reduced pressure, concentrate, filter to obtain extract 1, dry to obtain sample 1 (A).

[0030] 100g of medicinal materials, add 15 times the amount of 75% ethanol to soak, extract by dipping three times, each time for 1.0 hour, combine the extracts, extract the ethanol under reduced pressure until there is no alcohol smell, concentrate, filter to obtain extract 2, dry, and obtain Sample 2 (B).

[0031] 100g of medicinal material is soaked in 12 times the amount of 95% ethanol, heated and refluxed for three times, each time for 1.0 hour. Combine the extracts, recover the ethanol from the extracts under reduced pressure until there is no alcohol smell, concentrate, filter to obtain extract 3, and dry to obtain sample 3 (C).

Embodiment 2

[0032] Example 2 Purification method 1-reverse phase silica gel chromatography

[0033] The extract 2 in Example 1, the solvent was recovered under reduced pressure and concentrated to a liquid extract, and the above-mentioned concentrated extract was mixed with reversed-phase silica gel or diatomaceous earth (the ratio of sample to reversed-phase silica gel was 1:2.5), reversed-phase Purified by silica gel chromatography (the ratio of sample to reverse-phase silica gel is 1:80), eluted with water, 10% ethanol and 30% ethanol solvent, 50% ethanol eluted, recovered solvent under reduced pressure, filtered, dried, white and effective Site 1 (T-1).

Embodiment 3

[0034] Embodiment 3 refining method 2-solvent extraction method

[0035] Extract 2 in Example 1, the solvent was recovered under reduced pressure, filtered, the filtrate was extracted with ethyl acetate (volume ratio 1:1), and then extracted 5 times with n-butanol (volume ratio 1:1), filtered, and dried. Debai and effective part 2 (T-2).

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Abstract

The invention relates to an active part extracted from Chinese herb rhizome bletillae, a preparation method of the active part and an application of the active part in treating Alzheimer's disease (AD) and vascular dementia (VD). The animal test shows that the active part can apparently improve the memory acquisition disorder of cholinergic injury imitative dementia mouse caused by scopolamine, can improve the spatial learning and memory disorder of AD mouse caused by intracerebroventricular injection of Abeta and the spatial learning and memory disorder of the VD mouse caused by bilateral cervical general artery permanent ligation, and has an effect for apparently improving the animal learning memory disorder.

Description

Technical field: [0001] The present invention relates to the effective part extracted from the traditional Chinese medicine Baiji, the preparation method of the effective part, the pharmaceutical composition containing the effective part, and the effective parts containing the effective part and the pharmaceutical composition in the prevention and treatment of Alzheimer's disease. Dementia disease (AD) and vascular dementia (VD). Background technique: [0002] With the development of society, the prolongation of human life span and the increasingly serious phenomenon of social aging, the prevalence of senile dementia has increased significantly, and it has become the fourth leading cause of death. Senile dementia mainly includes Alzheimer's disease (Alzheimer's Disease, AD) and vascular dementia (Vascular dementia, VD). Alzheimer's disease is a progressive neurodegenerative disease, mainly manifested as neuropsychiatric symptoms such as progressive memory impairment, cognit...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P25/28
CPCA61K36/898A61K2236/331A61K2236/333A61K2236/55
Inventor 李帅张建军石建功徐瑞明韩少伟
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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