The invention relates to a preparation method of
terpenoid and
lignan substances in
eucommia ulmoides
bark or
eucommia ulmoides leaves and an application of the
terpenoid and
lignan substances in preparation of
senile dementia and AD (Alzheimer
disease) treatment drugs or healthcare food. The prepared
terpenoid substance in the
eucommia ulmoides
bark or the
eucommia ulmoides leaves is one or more of 1-deoxy-
delta4,5-eucommiol, 2,3-dyhydroxyl-
delta4,5-eucommiol, 5-hydroxyl-3,4-dihydroxymethyl-2-hydroxyethyl-cyclohex- 1-
enone-2'-O-beta-D-glucopyranoside), (6R, 7E, 9R)-megastigma-4,7-dien-3-one-9-O-[beta-D-xylopyranos-yl-(1'-6')-beta-D-glucopyranoside, (6S, 7E, 9R)-megastigma-4,7-dien-3-one-9-O-[beta-D-xylopyranos-yl-(1'-6')-beta-D-glucopyranoside] and the like. The prepared
lignan substance in the
eucommia ulmoides bark or the
eucommia ulmoides leaves is one or more of
pinoresinol-4,4'-O-beta-D-bis(glucopyranoside), 8-hydroxyl-
pinoresinol-4'-O-beta-D-glucopyranoside, lariciresinol-4,4'-O-beta-D- bis(glucopyranoside) and the like. The terpenoid and lignan substances have common or similar structural units such as eucommiol, megastigmane
sesquiterpene, bisepoxylignans, single-
epoxy lignans and the like, thereby having the similar
treatment effect in a
human body.