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Medicine for preventing and treating Alzheimer's disease (AD)

A technology of drugs and compounds, applied in the field of medicine, can solve problems such as undiscovered effects

Pending Publication Date: 2020-01-24
INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its role in the prevention and treatment of AD has not been found so far

Method used

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  • Medicine for preventing and treating Alzheimer's disease (AD)
  • Medicine for preventing and treating Alzheimer's disease (AD)
  • Medicine for preventing and treating Alzheimer's disease (AD)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0039] 1. Compound Preparation

[0040] After the fruit body of Inonotus obliquus is crushed into powder, it is leached three times with 95% ethanol aqueous solution, and the obtained leaching solution is filtered, combined and concentrated to form an extract. After that, add water and stir to form a suspension, and then extract with petroleum ether, ethyl acetate, and n-butanol, and extract each extraction layer until the extract is colorless. Each extract layer was evaporated and concentrated to make an extract for later use.

[0041] Take the extract from the ethyl acetate layer, pass it through a decompression column (silica gel H), and use petroleum ether: ethyl acetate (1:0 → 1:1) → chloroform: methanol (20:1 → 0:1) system gradient elution , and the resulting fractions were spot plate concentrated and combined to obtain 20 fractions (Fr.1-Fr.20).

[0042] Fr.6 and Fr.7 were combined (17.086g) and passed through a reversed-phase column, and eluted with a gradient of 50%...

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Abstract

The invention relates to the technical field of medicine, in particular to a medicine for preventing and treating Alzheimer's disease (AD). Research indicates that a compound shown in a formula I caninhibit activity of acetylcholinesterase and butyrylcholinesterase and protect nerve cells, thereby indicating that the compound can be used for preparing food and / or medicines for treating and / or preventing the AD. The compound is derived from medicinal fungus inonotus obliquus, has small side effects through verification and shows no physiological toxicity after gavage in 10 times dose.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for preventing and treating senile dementia. Background technique [0002] With the progress of society and the improvement of people's living standards, people's life expectancy is getting longer and longer. However, the incidence of some elderly high-morbidity such as neurodegenerative diseases is also increasing year by year. Senile dementia, also known as Alzheimer's disease (AD), is a type of degenerative disease, mainly manifested as degeneration of brain function, such as learning and memory loss, visual-spatial function damage (patients are prone to getting lost), Personality changes (apathy or irritability). With the increase of human life expectancy, AD has become one of the leading causes of death in developed countries. In developing countries, with the aging of the population, the proportion of AD patients is also increasing year by year, which brings ...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P25/28A61P25/00
CPCA61K31/575A61P25/28A61P25/00
Inventor 王昊戴好富陈志宝梅文莉魏艳梅
Owner INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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