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Pill composition used for preventing and treating Alzheimer disease and preparation method thereof

A composition and senile technology, applied in the direction of drug combination, sugar-coated pills, pill delivery, etc., can solve the problems of EGCG drop pill composition for the prevention and treatment of senile dementia, etc., and achieve quality controllable, convenient use, Overcome the effect of easy oxidation

Inactive Publication Date: 2011-01-26
上海强圣医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In a word, so far, there is no EGCG drop pill composition and other public information for the prevention and treatment of senile dementia both at home and abroad.

Method used

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  • Pill composition used for preventing and treating Alzheimer disease and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1E

[0033] The preparation of embodiment 1EGCG dropping pill composition 1

[0034] Prescription: EGCG 50g

[0035] Stearic acid 50g

[0036] Polyethylene Glycol-6000 100g

[0037] Vitamin E 0.5g

[0038] Preparation method: a. Weigh stearic acid and polyethylene glycol-6000 respectively, heat and melt them in a water bath at 85°C, cool to 75°C, weigh EGCG, and mix with polyethylene glycol-6000 and stearin Add EGCG at a ratio of 1:3 to the acid matrix, and finally add vitamin E, keep stirring at 65°C until uniform, and set aside.

[0039] b. Take the spare heat preservation EGCG and matrix mixture, adjust the temperature of the cooling liquid to 25°C to make the weight of the dropping pill reach 30mg±2mg, drop it into the simethicone cooling liquid at a uniform speed, and the dropping liquid will shrink, form and solidify into a pill , take it out, blot dry the simethicone oil with filter paper, and dry it for 5 hours with the natural wind passing through the...

Embodiment 2E

[0040] The preparation of embodiment 2EGCG dropping pill composition 2

[0041] Prescription: EGCG 15g

[0042] Stearic acid 5g

[0043] Polyethylene Glycol-6000 60g

[0044] tert-butyl-4-hydroxyanisole 0.015g

[0045] Preparation method: Same as the above method, after heating and melting stearic acid and polyethylene glycol-6000 matrix, add EGCG and tert-butyl-4-hydroxyanisole to mix well, put it in an incubator, and control the temperature at 80°C Keep warm, drop it into the liquid paraffin condensate at a uniform speed, make it condense into a spherical shape, take out and absorb the liquid paraffin to get the finished product, and dry it. The product obtained has a qualified release degree and good roundness.

Embodiment 3E

[0046] The preparation of embodiment 3EGCG dropping pill composition 3

[0047] Prescription: EGCG 20g

[0048] Stearic acid 10g

[0049] Polyethylene glycol-6000 25g

[0050] Poloxamer 40g

[0051] Alpha Lipoic Acid 0.15g

[0052] Preparation method: Same as the above method, heat and melt polyethylene glycol-6000, stearic acid and loxamer base, add EGCG and lipoic acid to mix well, put it in an incubator, control the temperature at about 70°C Drop it into the liquid paraffin condensate to make it condense into a spherical shape, take out and blot the liquid paraffin to get the finished product, and dry it. The obtained product has a qualified release degree and good roundness.

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Abstract

The invention discloses a pill composition used for preventing and treating Alzheimer disease and a preparation method thereof, in particular a pill composition used for preventing and treating the Alzheimer disease, which is prepared from an active ingredient (-)-epigallocatechin gallate (EGCG) and pharmaceutically acceptable accessories, and a preparation method for the pill composition. The invention has the outstanding characteristic of providing the pill composition which is safe, effective, quality-controllable and convenient to use for patients suffering from the Alzheimer disease.

Description

technical field [0001] The invention relates to a composition for preventing and treating senile dementia and a preparation method thereof, specifically an active ingredient (-)-epigallocatechin gallate (EGCG for short, the same below) and a pharmaceutically acceptable auxiliary material The drop pill composition for preventing and treating senile dementia comprises a preparation method of the drop pill composition. Background technique [0002] Entering the 21st century, the world is entering an era of aging, and senile dementia (also known as Alzheimer's disease, referred to as AD) has become the fourth major disease after cardiovascular and cerebrovascular diseases, tumors and other diseases. At present, the prevalence of senile dementia in the population over 65 years old is about 5%, and the global AD patients are estimated to be around 20-25 million; unlike most other diseases, the pathogenesis of senile dementia is extremely complicated, and it is not clear This reas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/28A61K31/353A61P25/28
Inventor 饶品昌程美君黎俊曾良珍
Owner 上海强圣医药科技有限公司
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