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Medicinal composition for treating Alzheimer's disease and preparation method and application of medicinal composition

A composition and drug technology, applied in the field of pharmaceutical compositions for treating Alzheimer's disease and their preparation, can solve the problems of improving AD symptoms, limited improvement of clinical symptoms, unsatisfactory long-term efficacy and the like

Inactive Publication Date: 2017-05-24
田金洲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently on the market are used to increase the level of acetylcholine, but the long-term efficacy is not satisfactory, and the improvement of clinical symptoms is limited
In addition, although many Aβ-targeted drugs can significantly reduce the Aβ level in the brain of AD animals, they have not been proved to have the effect of improving AD symptoms in human clinical trials (N Engl J Med 2013; 369:341 -350; N Engl J Med 2014; 370:322-333)

Method used

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  • Medicinal composition for treating Alzheimer's disease and preparation method and application of medicinal composition
  • Medicinal composition for treating Alzheimer's disease and preparation method and application of medicinal composition
  • Medicinal composition for treating Alzheimer's disease and preparation method and application of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The preparation of embodiment 1 pharmaceutical composition

[0068] Add 8 times the amount of water to Acorus calamus (150g), extract for 10 hours, collect volatile oil (the extraction rate of volatile oil is 1.26%), and collect the remaining liquid medicine and dregs after extracting the volatile oil in separate devices. Add the volatile oil to the saturated aqueous solution of β-CD (calculated by weight ratio, W 挥发油 :W β-CD =1:8), stirred at 50°C for 2 hours, placed at low temperature for 24 hours, filtered, and dried the obtained filter cake at 40°C to obtain the clathrate of volatile oil of Acorus calamus. Take the dregs after extracting the volatile oil and mix them with ginseng stems and leaves (290g), Poria cocos (430g), Rehmannia glutinosa (860g), Cornus officinalis (860g), Zhiyuanzhi (150g), fried jujube kernels (430g) and Baiziren (430g) Add 18 times of water and decoct at 60°C for 3 times, each time for 1 hour, filter, combine the filtrate, combine the filt...

Embodiment 2

[0069] The preparation of embodiment 2 granules

[0070] Add excipients (1:1) to the pharmaceutical composition prepared in Example 1 to make granules. (as ginsenoside Rg 1 and ginsenoside Re content are quality inspection indicators, and the active ingredient content of the unit preparation is 0.85%)

Embodiment 3

[0071] The preparation of embodiment 3 pills

[0072] Add appropriate amount of sodium carboxymethyl starch and microcrystalline cellulose to the pharmaceutical composition prepared in Example 1 to adjust the total amount to 1000 g, wherein 577 grams of the pharmaceutical composition, mix well, add an appropriate amount of 70% ethanol as a wetting agent, mix Uniform, pelletized, dried (below 40°C), subpackaged to obtain. (as ginsenoside Rg 1 and ginsenoside Re content are the investigation indexes, and the active ingredient content of the unit preparation is about 0.97%)

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Abstract

The invention provides a medicinal composition for treating the Alzheimer's disease and a preparation method and application of the medicinal composition. Specifically, the invention provides the medicinal composition which is prepared from the following traditional Chinese medicines: ginseng, poria cocos, rehmannia, dogwood, polygala tenuifolia, rhizoma acori graminei, jujube kernels and platycladi seeds. The invention further provides a preparation method and application of the medicinal composition. The medicinal composition is capable of remarkably inhibiting over phosphorylation of downstream tau protein and increasing the expression level of CaMKII, and has long-term effectiveness and security in treatment on senile dementia, particularly the Alzheimer's disease.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating Alzheimer's disease, a preparation method and application thereof. Background technique [0002] The prevalence of dementia in the elderly population in my country is about 7.3%, which is the country with the largest number of dementia in the world, and 60-80% of them are caused by Alzheimer's disease (Alzheimer's disease, AD). Alzheimer's disease is a neurodegenerative disease closely related to aging. The number of normal brain cells decreases, brain atrophy, and pathological metabolite deposition occurs at the same time, which affects normal brain function. The main clinical symptoms are memory loss and language ability decline. , Behavioral ability declines, and eventually develops and loses the ability to live. In 1906, German doctors first reported Alzheimer's disease and confirmed the neuropathological features of the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/28
CPCA61K36/076A61K36/14A61K36/258A61K36/40A61K36/69A61K36/725A61K36/804A61K36/888A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 田金洲时晶
Owner 田金洲
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