Application of cobra neurotoxin monomer molecules in treatment of senile dementia

Abstract

The invention discloses application of cobra neurotoxin monomer molecules in treatment of senile dementia. The senile dementia, also known as Alzheimer disease, is a senile disease with progressive memory disorder, obstacle of judgment and reasoning ability as well as dyskinesia as main clinical features. Evidence shows that strong focal inflammatory responses exist in the brains of the patients with the senile dementia, and activated microglia and astrocytes exist near senile plaques; and the activated microglia and astrocytes can express a plurality of inflammatory cytokines, including interleukin-1[beta] (IL-1[beta]), tumor necrosisfactor-alpha (TNF-alpha) and the like. Therefore, experts suggest that neurodegeneration may be caused by inappropriate activation of immune and inflammatoryreactions in the brain; and super-strong immune reactions can attack nerve tissue "in the wrong direction", thereby causing neuron damage and death. In order to solve the problems, the invention discloses a group of cobra neurotoxin monomer molecules which can inhibit increase of contents of related inflammatory factors, namely the IL-1[beta]) and the TNF-alpha, in the hippocampus of rats with the senile dementia, as well as significantly shorten escape latency of the rats with the senile dementia after treatment in Morris water maze experiment.

Description

technical field [0001] The invention relates to a group of cobra neurotoxin monomer molecules capable of inhibiting the level of inflammatory factors in the hippocampal brain tissue of senile dementia rats and improving the learning and memory ability of senile dementia rats and a method for treating senile dementia, belonging to the field of biopharmaceuticals. Background technique [0002] Senile dementia, also known as Alzheimer's disease (Alzheimer disease, AD), is an senile disease characterized by progressive memory impairment, judgment and reasoning impairment, and motor impairment. Dementia is an acquired and persistent intellectual disability syndrome caused by brain dysfunction. The incidence and prevalence of dementia increase with age. With the increasingly serious problem of population aging, AD has become the fourth leading cause of death in humans. [0003] The etiology of senile dementia is still unclear, and its pathogenesis is complicated. At present, rese...

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Problems solved by technology

[3,4] Therefore, some people put forward the hypothesis that although the initiating factors of neuronal degeneration in patients are different, and thus the outcome of different neuropathological damages, they may initiate the cascade reaction of inflammatory cytokines This similar process leads to neuron damage, and the release of a large number of inflammatory cytokines in the central nervous system of patients may aggravate the production of amyloid peptides, the accumulation of amyloid peptides in blood vessels, and the damage of white matter in the brain, thus causing a series of vicious circle of

[5] And it is this synergy that leads to fatal consequences

[6] In a study of how black mambas (cobra) venoms lead to high mortality, scientists found that potassium channel blocking activity is only one of them, and that there are various pathways, with different toxins acting in different Synthetic toxicity induced at the organ level is the concern for high mortality

[9] Cobra snake venom, as a mixture, has complex ingredients, difficult quality control, and the possibility of synergy between toxins is very high

[0010] In addition, technicians also try to treat neurological diseases with cobra neurotoxin mixtures. Neurotoxin mixtures may have a higher level of safety than snake venoms because they have reduced as much as possible cardiotoxins, cytotoxins, phospholipase A2, etc. A series of toxins reduces the severe toxicity of mixed snake venoms due to synergistic effects, but they are still a mixture of several neurotoxins, which still have the possibility of causing synergistic effects. For example, a synergistic effect of a cobra neurotoxin mixture may cause respiratory depression

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