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Application of magnolia sieboldii extract in preparation of anti-depression product

A technology of Magnolia serrata and its extract is applied to the application field of Magnolia serrata extract in the preparation of antidepressant products, which can solve the problem of not finding the application of Magnolia serrata extract, shorten the immobility time of TST, improve the quality of life, and improve the quality of life. The effect of expression

Active Publication Date: 2021-07-13
HUAANTANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of Tiannv Magnolia extract in the field of antidepressant has not been found yet

Method used

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  • Application of magnolia sieboldii extract in preparation of anti-depression product
  • Application of magnolia sieboldii extract in preparation of anti-depression product
  • Application of magnolia sieboldii extract in preparation of anti-depression product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment is the preparation of Magnolia leaf essential oil

[0036] This example adopts the preparation method of Example 1 in the application of patent CN 105708760 A Magnolia extract as a bacteriostatic agent to prepare Magnolia leaf essential oil. The specific preparation steps are as follows: take Magnolia leaves and crush them to 20 meshes, and put them in 4 series In the steam distillation reaction kettle, disperse evenly, add a net cover, pass in water vapor, open the condenser, react for 1 hour, collect the extract, separate oil and water, and obtain the essential oil extracted from the leaves of Magnolia magnolia.

Embodiment 2

[0038] This example establishes a mouse model for acute depression induced by reserpine

[0039] Principle: Reserpine inhibits central nervous system activity by depleting catecholamine and 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT) storage in brain tissue, which can cause body temperature drop, upper eyelid ptosis, anhedonia, and weight loss in rodents. Alleviation, decreased exercise capacity, etc.

[0040] Modeling: 5-week-old male KM mice (30±5g) were fed adaptively for one week before modeling. Reserpine is prepared and used now, and the prepared concentration is 0.6mg / mL. Except for the blank control group, the other groups are injected intraperitoneally according to the amount of 0.1mL / 10g of mouse body weight, and the dosage is 6mg / kg. Mice were given a single intraperitoneal injection of reserpine (6 mg / kg), which resulted in depressive symptoms lasting 72 hours after the injection. The blank group was given i.p. injection of DMSO / normal saline on the same day,...

Embodiment 3

[0043] This embodiment carries out forced swimming test (FST)

[0044]Put the mouse into a transparent glass tank with a diameter of 25 cm and a height of 30 cm, filled with 15 cm high water, the water temperature is 21-25 °C, the total recording time is 360 s, and the recorded data is within 120-360 s. The percentage of time the mouse is floating or slightly moving, which is used to reflect the degree of helplessness of the mouse.

[0045] figure 1 It is the histogram of the antidepressant-FST immobility time of this embodiment (compared with the model group, *Pfigure 1 It can be seen that compared with the model group, the swimming immobility time of the blank group, the positive control group, and the high-concentration and low-concentration administration groups of Magnolia leaf essential oil were all significantly reduced. group most notably.

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Abstract

The invention relates to the technical field of plant extracts, in particular to application of a magnolia sieboldii extract in preparation of an anti-depression product. The magnolia sieboldii extract disclosed by the invention has an excellent anti-depression effect, and experimental results show that the magnolia sieboldii extract can effectively shorten the FTS immobility time and the TST immobility time of a depressive mouse; the number of hippocampal neurons in brain tissues of the mouse is increased; the expression quantity of the BDNF protein in the brain tissue is improved.

Description

technical field [0001] The invention relates to the technical field of plant extracts, in particular to the application of Magnolia magnolia extract in the preparation of antidepressant products. Background technique [0002] According to data from the World Health Organization, depression ranks fifth among the top ten diseases in the world, second only to major diseases such as AIDS and heart disease, and seriously affects people's quality of life. For depression, among the common treatment methods, drug treatment is the most widely used, and the effect is relatively better. However, the current antidepressant drugs can cause irritation to the stomach, and also have adverse effects on the human immune system, bringing many side effects to people, such as dizziness, nausea, high blood pressure, constipation, etc. Overdose of drugs can cause acute poisoning and even death , Therefore, the current use of drugs to treat depression has a greater risk. [0003] Non-drug treatme...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61P25/24A61K8/92A61Q19/00A61K127/00
CPCA61K36/575A61K9/0043A61K9/007A61K9/0014A61P25/24A61K8/922A61Q19/00
Inventor 唐明慧艾勇宋妮何廷刚陈晓露梁乐怡
Owner HUAANTANG BIOTECH GRP CO LTD
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