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Composition for preventing and/or delaying old people with mild cognitive impairment and use method thereof

A technology for cognitive impairment and mild elderly people, applied in the fields of health care products and food, can solve the problems of unknown causes, no effective prevention or treatment of MCI, difficult diagnosis, etc., to improve antioxidant capacity, improve learning and memory impairment, The effect of improving the effect

Inactive Publication Date: 2017-02-15
王全峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

MCI is an early stage of senile dementia. The specific cause of MCI is unknown and difficult to diagnose. At present, there is no effective preparation or method for preventing or treating MCI.

Method used

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  • Composition for preventing and/or delaying old people with mild cognitive impairment and use method thereof
  • Composition for preventing and/or delaying old people with mild cognitive impairment and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Experimental animals: 70 Kunming Alzheimer's disease model mice, SPF grade, male and female, weighing (20±2) g, were provided by the Animal Center of Dalian Medical University. The Alzheimer's disease mouse model is obtained by conventional methods, specifically: observe the general state of the Kunming mice, grab the Kunming mice, anesthetize the Kunming mice with 10% chloral hydrate, fix the mice, Under sterile conditions, inject 5 μl of condensed Aβ into the bilateral ventricle of the mouse at one time with a micro-injector 1-42 (80pmol / μl), leave the needle for 2 minutes, wrap the mouse, let the mouse rest fully, and prevent infection. At the same time, the same method was used to inject the same amount of normal saline into the bilateral cerebral ventricle of the mice in the control group.

[0030] 2. Grouping and administration of experimental animals: Alzheimer's disease mice were randomly divided into 6 groups according to body weight and gender, namely mode...

Embodiment 2

[0051] Determination of Aβ, IL-6 and IL-12 protein content in mouse hippocampus:

[0052] Two hours after the end of the Morris water maze test in Example 1, the mice in each group were decapitated on the ultra-clean workbench, the brain tissue skin was removed, the craniotomy was performed, and the complete mouse brain tissue was taken out and placed on the ice platform. The brainstem and cerebellum were removed, and the hippocampus tissues of the mice in each group were quickly collected, homogenized, placed in a refrigerator at 4°C, centrifuged at 5000rpm for 10 minutes, the supernatant of the hippocampus tissue was drawn, aliquoted, and stored at -20°C. According to the instructions of the enzyme-linked immunosorbent assay kit, the absorbance of each well was measured, and the contents of Aβ, IL-6 and IL-12 proteins in the hippocampal tissue of the mouse were obtained. The results are shown in Table 2.

[0053] From the analysis of the results in Table 2, it can be seen th...

Embodiment 3

[0059] 1. Experimental animals and grouping and administration of experimental animals: see Example 1.

[0060] Control group, model group, hemp seed + coconut oil group: gavage with normal saline at 9:00;

[0061] Coffee group: at 9:00 gavage solution of high coffee coffee, the gavage volume is 764mg high coffee coffee / kg;

[0062] Folic acid group: at 9:00, use folic acid gavage solution, the gavage volume is 52 μg folic acid / kg;

[0063] Melatonin group: 20:00 gavage solution with melatonin, the gavage volume is 637 μg melatonin / kg;

[0064] Combination group: 9:00 gavage with coffee and folic acid mixed gavage solution, the gavage volume is 764 mg coffee / kg, 52 μg folic acid / kg); 20:00 gavage with melatonin gavage solution, gavage volume is 637 μg melatonin Vegetables / kg.

[0065] Wherein, the intragastric solution of the coffee group, the folic acid group, the melatonin group and the combination group is prepared by dissolving the corresponding components in physiologica...

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Abstract

The invention discloses a composition for preventing and / or delaying old people with mild cognitive impairment and a use method thereof; the composition comprises the following components in parts by weight: 3000-6000 parts of a coffee powder, 0.2-0.4 part of folic acid, 15000-30000 parts of coconut oil, 15000-30000 parts of semen cannabis, and 3-5 parts of melatonin, wherein the coffee powder contains 3.6-4.2 wt% of caffeine. The composition can improve the antioxidant capacity of brain tissues and prevents the brain tissues from being damaged by free radicals. Animal experiments indicate that the composition can effectively improve learning and memory impairment in Alzheimer's disease model mice; human body test-meal experiments indicate that the old people with mild cognitive impairment take the composition at a specific point in time, and have a significant improving effect on memory improvement. With regular effective taking of the composition, the old people with mild cognitive impairment can be prevented from suffering from Alzheimer's disease, or the incidence time can be delayed.

Description

technical field [0001] The invention relates to the technical fields of food and health products, in particular to a composition for preventing and / or delaying the aging mild cognitive impairment (MCI) and its application method. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is a progressive and fatal neurodegenerative disease. and behavioral disorders. Clinically, it is characterized by generalized dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. [0003] AD is one of the most common diseases in the elderly, and the World Health Organization (WHO) estimates that the prevalence of AD in the elderly population over 65 years old is 4% to 7%. The prevalence of AD is closely related to age, and the prevalence rate doubles for every 6.1 years of age increase on average; in the elderly population over 85 years old, the prevalence rate of AD ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P25/28A61P25/00A61P37/04A23L33/00A23L33/10A23L33/15A23L33/115A61K31/519A61K31/4045
CPCA61K36/74A23V2002/00A61K31/4045A61K31/519A61K36/60A61K36/889A61K2300/00A23V2200/322
Inventor 王全峰曹传海袁波张晓影王泽青霍江浩
Owner 王全峰
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