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Application of pseudobulubs cremastrae seu pleiones' effective part in treatment of senile dementia

An effective part, the technology of Arrowhead mushroom, which is applied in the field of medicine, can solve the problems that there are no research reports on the treatment of senile dementia with Arrowhead mushroom

Inactive Publication Date: 2014-12-03
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been no research reports on the treatment of senile dementia with Shanzi mushroom

Method used

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  • Application of pseudobulubs cremastrae seu pleiones' effective part in treatment of senile dementia
  • Application of pseudobulubs cremastrae seu pleiones' effective part in treatment of senile dementia
  • Application of pseudobulubs cremastrae seu pleiones' effective part in treatment of senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Shanzi mushroom medicinal material (derived from Suanlan or Yunnan Suanlan) 1kg, soaked in 8 times the amount of 50% ethanol, heated and refluxed for three times, 1.0 hour each time. The extract is decompressed to recover ethanol and concentrated to an alcohol-free solution, filtered, and the filtrate is passed through the treated D-101 macroporous adsorption resin (the weight of the medicinal material: the volume of the resin is 1:1), and firstly use 8 times the volume of the resin column with water and 4 times the volume of the resin column was eluted sequentially with 15% ethanol, and then eluted with 8 times the volume of the resin column with 40% ethanol, and the 40% ethanol eluate was recovered under reduced pressure, and evaporated to dryness under reduced pressure to obtain the organic acid benzyl Effective part of ester glycoside.

Embodiment 2

[0029] Arrowhead mushroom medicinal material (derived from Suanlan or Yunnan Suanlan) 1kg, add 12 times the amount of 75% ethanol to soak, heat and reflux extract three times, 1.0 hour each time. Recover ethanol from the extract under reduced pressure and concentrate to extract, mix the sample with silica gel or diatomaceous earth (the ratio of sample to silica gel or diatomaceous earth is 1:1~2), and perform normal phase silica gel chromatography (the ratio of sample to silica gel is 1:1: 50~100) refined, 5 times the volume of petroleum ether-acetone (100:0~1:1) gradient elution to remove fat-soluble impurities, and then 5 times the column volume of chloroform, chloroform-methanol (10:1), and chloroform-methanol (5:1) elution, collected chloroform-methanol (5:1) eluted part and evaporated to dryness under reduced pressure to obtain the effective part of benzyl ester glycoside of Arrowhead organic acid.

Embodiment 3

[0031] Add 12 times the amount of 75% ethanol to 1 kg of Shanzi mushroom medicinal material (Dulan or Yunnan), soak it in 75% ethanol, heat and reflux extract three times, each time for 1.0 hour. Recover ethanol from the extract under reduced pressure and concentrate it to the extract. Mix the above-mentioned concentrated extract with reversed-phase silica gel or diatomaceous earth (the ratio of sample to reversed-phase silica gel is 1:2~5), reverse-phase silica gel chromatography (sample and reversed-phase silica gel) Reversed-phase silica gel (ratio: 1:80-200) refined, eluted with 4 times column volume of water, 10% ethanol and 30% ethanol solvent, then eluted with 3 times column volume of 50% ethanol, evaporated to dryness under reduced pressure, and obtained The active part of the organic acid benzyl ester glycoside of arrowhead mushroom.

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Abstract

The invention relates to an effective part extracted from the traditional Chinese medicine pseudobulubs cremastrae seu pleiones (with plant root in Pleione bulbocodioides and Pleione yunnanensis), a preparation method, and application thereof in treatment of senile dementia and vascular dementia. Animal tests prove that the effective part can obviously improve the learning and memory disorder of scopolamine induced mouse cholinergic impairment analog dementia animal models, can enhance the recognition capability of common carotid artery ligation induced vascular dementia rats on new objects, and can improve the object recognition disorder and spatial learning and memory disorder caused by vascular dementia. With antioxidant capacity, the pseudobulubs cremastrae seu pleiones' effective part can reach the effect of delaying degenerative changes of nerve cells by reducing oxidative damage response.

Description

technical field [0001] The present invention relates to the effective part extracted from the traditional Chinese medicine Arrowhead Arrowhead (the plant comes from Suanlan and Yunnan Suanlan), the preparation method of the effective part, the pharmaceutical composition containing the effective part, and the effective part containing the effective part The invention and the application of the pharmaceutical composition thereof in the prevention and treatment of senile dementia and vascular dementia belong to the technical field of medicine. Background technique [0002] With the development of society, the prolongation of human life span and the increasingly serious phenomenon of social aging, the prevalence of senile dementia has increased significantly, and it has become the fourth leading cause of death. Senile dementia mainly includes Alzheimer's disease (Alzheimer'Disease, AD) and vascular dementia (Vascular dementia, VD). Alzheimer's disease is a progressive neurodege...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P25/28
Inventor 李帅张建军石建功崔保松李新娅徐瑞明王晓娟王超冀呈雪
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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