The use of new cornus glycosides in the preparation of medicaments for the treatment of Alzheimer's disease

A new glycoside and drug technology from Cornus officinalis, applied in the field of secoiridoid derivatives, can solve the problems of no neurodegenerative disease reports, achieve good medicinal prospects, no toxic and side effects, and easy to use

Active Publication Date: 2021-07-09
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Currently, Chinese patent applications CN105017353A and CN105017353A disclose preparation methods for split ring iridoids, Chinese patent application CN101704857A discloses a separation and purification process, and Chinese patent applications CN106680399A, CN104991002A, CN105486775A, and CN104147079A disclose content determination methods. See any report on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis

Method used

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  • The use of new cornus glycosides in the preparation of medicaments for the treatment of Alzheimer's disease
  • The use of new cornus glycosides in the preparation of medicaments for the treatment of Alzheimer's disease
  • The use of new cornus glycosides in the preparation of medicaments for the treatment of Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Tablets with cornel glycosides as raw materials.

[0109] Each 1000 tablets contains the following ingredients:

[0110] Cornus officinale glycosides 15g, hydroxypropyl methylcellulose 30g, talc powder 0.4g, lactose 0.2g, magnesium stearate 0.2g, absolute ethanol amount, made into 1000 tablets.

[0111] When preparing the above-mentioned tablet, take cornel glucoside, mix evenly with hydroxypropyl methylcellulose, talcum powder, lactose, and magnesium stearate, add absolute ethanol to make a soft material, pass through a 24-mesh sieve, and make granules. Dry, add magnesium stearate, mix well, and compress into tablets.

Embodiment 2

[0112] Embodiment 2 is the same as embodiment 1 except that hydroxypropyl methylcellulose is 45 g.

Embodiment 3

[0113] Embodiment 3 is the same as embodiment 1 except that hydroxypropyl methylcellulose is 75 g.

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Abstract

The invention relates to a new application of split iridoid derivatives in the field of pharmacy, in particular to the application of split ring iridoid derivatives in the preparation of drugs for preventing and treating neurodegenerative diseases. In the treatment of neurodegenerative diseases, this type of product can significantly increase the activity of nerve cells and exert an obvious neuroprotective effect. The protective effect on the SH‑SY5Y cell model damaged by hydrogen peroxide is stronger than that of loganin, Morroniside can significantly improve the learning and memory impairment of aging individuals, and significantly increase the total antioxidant capacity in brain tissue.

Description

technical field [0001] The present invention relates to the use of split ring iridoid derivatives, in particular to the application of split ring iridoid derivatives in the preparation of drugs for the prevention and treatment of neurodegenerative diseases. Background technique [0002] Alzheimer's disease (AD) is a severe chronic neurodegenerative disease that mainly occurs in old age. The main pathological changes in the brain of patients are amyloid plaques in the forebrain base, hippocampus and cerebral cortex ( senile plaques, SP) deposition, neurofibrillary tangles (neurofibrilla tangles, NFT), loss of neurons and synapses, and cholinergic hypofunction. [0003] Drugs for the treatment of neurodegenerative diseases mainly include antioxidants, anti-inflammatory agents, and anti-apoptotic agents. Among them, most of the therapeutic drugs for Alzheimer's disease are cholinesterase inhibitors, such as tacrine, donepezil, rivastigmine and the like. [0004] Traditional C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P25/28
CPCA61K31/7048A61P25/28
Inventor 张维库续洁琨贺晓丽赫军连雯雯王泽星
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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