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A traditional Chinese medicine composition for improving memory and mild cognitive impairment and preparation method thereof

A technology for mild cognitive impairment and memory improvement, which is applied in the field of medicine, can solve the problems of high toxicity and side effects, and cannot prevent the development of the disease, and achieve the effects of definite curative effect, reducing the content of lipofuscin in neuron cells, and enhancing activity

Active Publication Date: 2020-02-21
深圳市锦泰医药科技合伙企业有限合伙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned drugs are mainly chemical drugs, which have relatively large toxic and side effects
[0004] The 2010 European "Guidelines for the Treatment of AD" pointed out that cholinesterase inhibitors are the first choice for AD drug treatment, which can improve the clinical symptoms of memory and cognitive dysfunction, but cannot prevent the development of the disease process.
However, since memory and mild cognitive impairment may develop into severe AD, long-term medication is required, and drug resistance after long-term administration of cholinesterase inhibitors

Method used

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  • A traditional Chinese medicine composition for improving memory and mild cognitive impairment and preparation method thereof
  • A traditional Chinese medicine composition for improving memory and mild cognitive impairment and preparation method thereof
  • A traditional Chinese medicine composition for improving memory and mild cognitive impairment and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Raw materials: Gastrodia elata 100g, polygala 60g, calamus calamus 60g, ginseng 60g, mulberry seeds 100g, ginkgo leaves 100g add 12 times water, reflux extraction for 1 hour, filter, filtrate for later use, add water 10 times to medicinal residues, reflux extraction for 1 hour, Filtrate, combine the filtrates, concentrate, dry, add 0.1 g of borneol, mix well and pack into capsules (it should be understood that this embodiment can also be made into pills, tablets, etc. by the methods commonly used in pharmacy).

Embodiment 2

[0025] Raw materials: Gastrodia elata 100g, polygala 60g, calamus 60g, ginseng 60g, mulberry seeds 100g, ginkgo leaves 100g and borneol 0.1g. Each medicinal material is crushed into fine powder. Add 8-16 times (weight) of 60% ethanol to Polygala, Shichangpu, Ginseng, Gastrodia elata, Chushizi, Ginkgo biloba, etc., decoct for 1 hour, filter, and set aside the filtrate; add 8-16 times (weight) to the filter residue 60% ethanol, decoct for 1 hour, filter, discard the filter residue, combine the previous filtrate, concentrate, dry, and make dry extract powder; mix dry extract powder and borneol fine powder evenly, granulate or pellet, pack Capsules (it should be understood that this embodiment can also be made into pills, tablets, etc. by the methods commonly used in pharmacy).

Embodiment 3

[0027] Raw materials: Gastrodia elata 100g, polygala 60g, calamus 60g, ginseng 60g, mulberry seeds 100g, ginkgo leaves 100g and borneol 0.1g. Add 8-16 times (weight) of 60% ethanol to Polygala, Shichangpu, Ginseng, Gastrodia elata, Chushizi, Ginkgo biloba, etc., decoct for 1 hour, filter, and set aside the filtrate; add 8-16 times (weight) to the filter residue 60% ethanol, decoct for 1 hour, filter, discard the filter residue, combine the previous filtrate, concentrate; add borneol, then add appropriate additives and purified water to adjust to the specified concentration, and make a liquid preparation such as a mixture.

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Abstract

The invention provides a traditional Chinese medicine composition for improving memory and mild cognitive impairment. The traditional Chinese medicine composition comprises 40-80 parts of thinleaf milkwort root-bark, 40-80 parts of grass leaf sweetflag rhizome, 40-80 parts of ginseng, 80-120 parts of tall gastrodia tuber, 80-120 parts of papermulberry fruit, 80-120 parts of ginkgo leaves and 0.01-3 parts of borneol. The traditional Chinese medicine composition can achieve the effects of obviously increasing the number density and surface density of synapse of the molecular layer of mouse hippocampal CA1, obviously enhancing the SOD activities of central cerebral cortex and hippocampus, reducing the content of lipofuscin of the neuron, obviously improving the learning and memory impairment of spontaneous senile dementia model mice, obviously enhancing the activity and fiber density of NOS1 of the central cerebral cortex and hippocampus and obviously up-regulating the contents of SS, AVP and ACTH of the cerebral cortex and hippocampus, especially the content of SS. The traditional Chinese medicine composition can achieve the effect of obviously improving the clinical symptoms of memory and cognitive impairment and has definite curative effects and great application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for improving memory and mild cognitive impairment, a traditional Chinese medicine preparation and a preparation method thereof. Background technique [0002] China has entered an aging population society. Statistics show that by the end of 2015, China's elderly population over the age of 60 had reached 212 million, accounting for 15.5% of the total population. my country has become a large aging country in the world. According to reports, 10% of the elderly over the age of 65 in the world suffer from senile dementia, and the prevalence rate over the age of 80 is as high as 20%. Alzheimer's disease (Alzheimer's disease, referred to as AD) has become the fourth largest killer of human beings after heart disease, cancer, and stroke. Its initial clinical symptoms are memory and cognitive dysfunction, and the age of onset is getting young...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P25/28A61K31/045
CPCA61K31/045A61K36/16A61K36/258A61K36/60A61K36/69A61K36/888A61K36/8988A61K2236/333A61K2300/00
Inventor 梁少瑜吴正治曾永长
Owner 深圳市锦泰医药科技合伙企业有限合伙
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