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146 results about "Optogenetics" patented technology

Optogenetics (from Greek optikós, meaning 'seen, visible') is a biological technique that involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure these manipulation effects in real-time. The key reagents used in optogenetics are light-sensitive proteins. Neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while optical recording of neuronal activities can be made with the help of optogenetic sensors for calcium (GCaMP), vesicular release (synapto-pHluorin), neurotransmitter (GluSnFRs), or membrane voltage (arc lightning, ASAP1). Control (or recording) of activity is restricted to genetically defined neurons and performed in a spatiotemporal-specific manner by light.

Animal behavior test platform regulated by optogenetics

The invention relates to an animal behaviour testing platform for optogenetics regulation and control, used for carrying out a behaviour test on tested animals. The testing platform comprises a central control system, an environmental control system, a behaviour monitoring system, a photoelectric detection, regulation and control system and a case device used for fixing the systems. A standard and integrated behaviour testing platform used for testing animal optogenetics regulation and control is established by combining an optogenetics neural regulation and control technology and electrophysiology and behaviour tests and the like; by virtue of the platform, optogenetics regulation and control as well as behaviour record on the tested animals in certain environment can be realized, thus being easy to understand relation between the animal optogenetics regulation and control and the behaviour and meeting requirements of research on pathogenesis and treatment mechanism of a nervous system and mental diseases.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

Light control and neural information detection system

InactiveCN106108858ARich stimulation modesStimulation parameters are adjustableDiagnostic signal processingDiagnostics using lightOptogeneticsData acquisition
The invention discloses a light control and neural information detection system. The system comprises a light stimulation control module, an electrochemical detection module, an electrophysiological detection module, a synchronous data acquisition module, a main control module and a synchronous control module, wherein the light stimulation control module can be combined with the optogenetics technology to carry out light control via laser fibers or LED lamp electrodes; the electrochemical detection module is used for detecting neurochemical signals; the electrophysiological detection module is connected with a microelectrode array and is used for detecting neural electrophysiological signals; the synchronous data acquisition module is used for synchronously acquiring neural electrochemical and electrophysiological signals; the main control module is used for carrying out synchronous coordinated control on light stimulation and neural signal detection and completing data communication; the synchronous control module is used for completing the functions of man-machine interaction, data processing, display, analysis and storage, and the like. The system can be used for solving the problems that light control and signal detection are difficult in synchronous and experiment operation is fussy in the research on neurosciences.
Owner:INST OF ELECTRONICS CHINESE ACAD OF SCI

System and method for optogenetic therapy

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
Owner:CIRCUIT THERAPEUTICS

Empathy nerve experiment system based on observational fear acquisition

The invention provides an empathy nerve experiment system based on observational fear acquisition. The empathy nerve experiment system based on observational fear acquisition comprises a behavioristics implementation device, a video monitoring device, a physiological signal acquisition device, a light control device and an electric signal acquisition device. The behavioristics implementation device comprises an observational fear acquisition experiment box, and a victim mouse and an observer mouse are put in the observational fear acquisition experiment box in the experiment process. The observational fear acquisition experiment box is used for carrying out an electric shock on the victim mouse. The light control device is used for carrying out specific neuron irradiation on a target region of brain tissue of the victim mouse. The video monitoring device is used for acquiring behavior reactions of the observer mouse. The physiological signal acquisition device is used for acquiring physiological reactions of the observer mouse. The electric signal acquisition device is used for acquiring activity signals of the observer mouse. The empathy nerve experiment system can be used for evaluating the emotional empathy states of animals and exploring relevant neural circuit mechanisms in combination with optogenetics.
Owner:SHENZHEN INST OF ADVANCED TECH
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