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46 results about "Maternal body" patented technology
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Definition of maternal body. The term “maternal body” describes women’s embodied potential for getting pregnant, giving birth, and becoming a mother, with responsibility for nurturing (and perhaps breastfeeding) infant children. Feminist research on organisational cultures has observed how some employers are hostile towards the maternal body.
Fetal monitoring
ActiveUS20100185108A1Consistent measurementConveniently determinedElectrocardiographySensorsObstetricsPartial representation
A system for monitoring a fetus during gestation comprises an input for receiving a plurality of electric signals measured on a surface of a maternal body; and means for providing a fetal electrocardiogram based on the received electric signals and based on an orientation of the fetus, wherein the fetal electrocardiogram represents a projection of a fetal cardiac potential vector according to a predetermined projection direction that is fixed with respect to the fetus. The fetal vector electrocardiogram is projected according to the projection direction. An at least partial representation of a fetal vector electrocardiogram is provided in dependence on the plurality of electric signals and indicative of a time path of an electrical field vector generated by a fetal heart of the fetus.
Owner:NEMO HEALTHCARE
Preparation method of placenta-source decidua parietalis mesenchymal stem cells by separation and refrigeration
InactiveCN105238748ARich resourcesPromote growthDead animal preservationSkeletal/connective tissue cellsMotilitySimple component
The invention provides a preparation method of placenta-source decidua parietalis mesenchymal stem cells by separation and refrigeration. According to the preparation method, puerpera is screened before placenta acquisition, and placenta from healthy mature puerperas volunteers who give birth to baby boys is finally selected as the acquisition target; separation and amplification are carried out for large-scale culture until the third generation, and refrigeration and preservation are carried out; and an intermediate product obtained from the separation process and refrigeration process undergoes a series of quality detections such as maternal detection, and cells are resurrected and washed for later use after refrigeration. There is no obvious reduction of motility rate, and biological functions of cells are complete. The placenta-source decidua parietalis mesenchymal stem cells have a simple component, and the whole process from raw material acquisition to cell preparation is monitored clinically, unitedly and systematically so as to realize a clinic standard product of mesenchymal stem cells. Besides, decidua parietalis comes from mother and is more suitable to be used by maternal body.
Owner:SHANGHAI BIOZONE BIOTECH CO LTD
Fetal monitoring
ActiveUS8332021B2Consistent measurementConveniently determinedElectrocardiographySensorsObstetricsFetal monitoring
Owner:NEMO HEALTHCARE
Biological feedback type delivery physical analgesia device
ActiveCN102940934BAccurate responseContinuous responseElectrotherapyDiagnostic recording/measuringWorkstationElectrical stimulations
Owner:GUANGZHOU SUNRAY MEDICAL APP
Reference product for non-invasive prenatal detection of fetal aneuploid chromosomes
ActiveCN109112209AEasy to makeQuantitatively accurateMicrobiological testing/measurementDNA/RNA fragmentationReference productQuality control
The present invention provides a reference product for non-invasive prenatal detection of fetal aneuploid chromosomes. The reference product comprises: a first fragmented nucleic acid derived from thetissue of a maternal body having normal chromosome ploidy or the cultured cell line genome, and a second fragmented nucleic acid derived from the tissue or the cultured cell line genome of a fetus with positive chromosome aneuploidy, wherein the first fragmented nucleic acid is genetically related to the second fragmented nucleic acid, the first fragmented nucleic acid at least accounts for 70% of the total nucleic acid amount of the reference product, and the second fragmented nucleic acid accounts for 5-30% of the total nucleic acid amount of the reference product. According to the presentinvention, the reference product is easy to prepare, meets clinical practical demands, is used for the research and development and quality control on non-invasive prenatal detection related products,and has important application prospects.
Owner:国家卫生健康委科学技术研究所 +1
Maternal nourishing milkshake powder and preparation method thereof
ActiveCN103999942AEfficient use ofPlay a role in weight controlMilk preparationBiotechnologyIcing sugar
The invention discloses maternal nourishing milkshake powder and a preparation method thereof, and in particular relates to the milkshake powder which is convenient to eat and has an auxiliary protective effect on recovery of a maternal body, belonging to the technical field of special dietary food and milk product processing. The maternal nourishing milkshake powder is characterized by consisting of whole milk powder, skimmed milk powder, whey protein powder, brown powdered sugar, inulin, casein phosphopeptides, soluble soybean polysaccharides and lactoferrin. The maternal nourishing milkshake powder has the advantages that the effects of nutrition complementation and collaborative gain are fully achieved; the market blank is filled; the food, such as vegetables, fruits, millet and red beans, required by puerperae can be supplemented according to individual needs; the maternal nourishing milkshake powder is conveniently and safely eaten, provides comprehensive nutrition, can be favorable to the recovery of the maternal body, and has an auxiliary protective effect on the puerperae and infants; unwell symptoms, such as postpartum constipation and anemia, can be prevented and improved remarkably after the maternal nourishing milkshake powder is eaten; meanwhile, the immunity can be enhanced; the comprehensive health of the puerperae and the infants are maintained; the color, the taste, the stability and the like of the product do not have any adverse influence; hazards and side effects on bodies cannot be caused by taking the maternal nourishing milkshake powder normally.
Owner:李卫平
Method for predicting re-pregnant vaginal birth after cesarean delivery
InactiveCN106264462ABest cut-off scoreQuality improvementDiagnostic recording/measuringSensorsObstetricsReceiver operating characteristic
The invention relates to a method for predicting re-pregnant vaginal birth after cesarean delivery. The method comprises the following steps: S1: collecting a large number of clinical data of pregnant and lying-in women experiencing re-pregnant trial vaginal birth after cesarean delivery; S2: comparing the clinical data of two groups of pregnant and lying-in women, screening independent influence factors for influencing successful re-pregnant trial vaginal birth after cesarean delivery, and calculating an odds ratio (OR) of each influence factor; S3: grading and classifying the independent influence factors, scoring the obtained odds ratios (OR) in combination with Logistic regression analysis so as to establish a predictive scoring table used before the re-pregnant vaginal birth after cesarean delivery; S4: according to the predictive scoring table, scoring the collected independent influence factors of each pregnant and lying-in woman, calculating a total score value, and drawing the total score values of all the pregnant and lying-in women into an ROC (receiver operating characteristic) curve to obtain an optimal critical score value, namely a cut-off point, wherein the cut-off point is a critical score value for judging whether a pregnant woman can accomplish the vaginal birth. By the method, a safe and feasible before-birth predictive scoring model for VBAC (vaginal birth after cesarean delivery) is established.
Owner:福建省妇幼保健院
Method for producing cloned dog
InactiveCN101225382AOvercome the defect of low cloning efficiencyAnimal reproductionFrame fasteningFemale dogNuclear transfer
The invention provides a method for cloning dog, comprising: producing the enucleated oocytes by enucleating the oocytes; transplanting the somatic cell of dog into the enucleated oocytes; producing the nuclear transfer embryos by electrofusion at the optimum condition; and transplanting the nuclear transfer embryos into surrogate maternal body. The said method has high efficiency and great contribution to animal medicine, anthropology and medicine, such as propagation of good breed, heterogeneity and animal in illness model. In addition, the method successfully clones female dog for the first time and can more accurately research the propagation features of the cloning dog.
Owner:SEOUL NAT UNIV R&DB FOUND
Fetal concentration quantification method and device and fetal genotyping method and device
PendingCN110993025AAccurately reflect genetic backgroundImprove scalabilityMedical simulationProteomicsData setPhysiology
The invention provides a fetal concentration quantification method and device and a fetal genotyping method and device. The fetal concentration quantification method comprises the following steps: acquiring sequencing data containing a plurality of SNP sites; recording the mutation frequencies of all SNP sites in the sequencing data, and classifying the SNP sites with the mutation frequency of 1%-25% into a first type of frequency, and classifying the SNP sites with the mutation frequency of 75%-99% into a second type of frequency, wherein the second type of frequency is equal to 1-mutation frequency; calculating a median or a mean value of a data set formed by the two frequencies, wherein the median or the mean value is twice of the median or the mean value to obtain the fetal concentration. Based on differential SNP sites of fetuses and maternal bodies, the fetal concentrations of the male fetus and the female fetus are accurately quantified, and then whether the fetus inherits mutation from the mother or the father under the background of mother mutation or not can be accurately detected in combination with the maternal background provided by the leukocyte sample of the pregnantwoman, so the problem that fetal genotyping is difficult to perform under the background of maternal mutation is solved.
Owner:BEIJING KEXUN BIOTECH CO LTD
Referral index of critically ill pregnant and lying-in women
InactiveCN102008352AReduce deathReduce mortalitySurgeryDiagnostic recording/measuringCritical illnessMortality rate
The invention discloses a referral index of critically ill pregnant and lying-in women, which includes parameter acquisition, a data evaluation system and a referral suggestion. The referral index comprises the steps of: collecting six parameters including the systolic pressure, pulse, breathe, consciousness, platelet count and oxygen saturation of blood of a critically ill pregnant and lying-in woman; evaluating the six parameters according to the data evaluation system and calculating the pre-referral index; and providing a referral suggestion according to the index grade. The pre-referral index is used for the rapid quantitative evaluation of disease severity of critically ill pregnant and lying-in women by basic medical units so that the critically ill pregnant and lying-in women can be immediately transferred based on the referral index, thereby being beneficial to the improvement of rescue level of critical illness, and lowering the mortality rate of pregnant and lying-in women and perinatal fetuses.
Owner:广州医学院第三附属医院
Apparatus and method for monitoring fetus in maternal body
ActiveUS8483810B2Reduce noiseImprove accuracyElectrocardiographyHeart defibrillatorsFetal movementPost processor
An apparatus for monitoring fetal positions and fetal movements is provided. The apparatus includes a plurality of sensors, a signal pre-processor, a signal post-processor, and a fetal position judging processor. The sensors are attached on the abdomen of a maternal body to provide at least three measuring leads. The signal pre-processor receives a plurality of sensing signals from the sensors, and the signal pre-processor reduces noises in the sensing signals and amplifies the sensing signals to output a plurality of characteristic sensing signals. The signal post-processor receives the characteristic sensing signals from the signal pre-processor and separates out a plurality of fetal electrocardiograms (FECGs) corresponding to the leads. The fetal position judging processor analyzes the FECGs to obtain a characteristic waveform for each of the FECGs or directly calculates a fetal heart axis vector with respect to a front-side coordinate of the maternal body according to the FECGs.
Owner:IND TECH RES INST +1
Kit for assisting in detection of placenta implantation and application thereof
InactiveCN109557320AConvenient auxiliary detection meansFast auxiliary detection meansBiological testingObstetricsNormal delivery
The invention applies an agent capable of detecting VEGF-A concentration to detect peripheral blood of pregnant women. The VEGF-A concentration of peripheral serum of a normal delivery pregnant womanbefore delivery is taken as a reference value, peripheral blood of a pregnant woman to be detected is taken as a detection value, and the detection value / reference value is taken as a cutoff value by1.0 to prepare a kit for assisting in the detection of placenta implantation. The kit not only has medium-intensity discrimination performance for pregnant women with placenta implantation and pregnant women with normal delivery, but also has medium-intensity discrimination performance for pregnant women with placenta implantation and pregnant women whose assisting diagnosis result is a false positive by using other methods. The kit provides a convenient and quick assisting detection method. Concentration data obtained by detection is used as a reference value, which can be combined with results of other methods, and is beneficial to improve accuracy of risk screening for pregnant women with placenta implantation.
Owner:THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
Method for rapid expanding propagation of melon germplasm resources
ActiveCN110249929AThe method is simple and fastReduce breeding costsHorticulture methodsPlant genotype modificationPropaguleGermplasm
The invention discloses a method for rapid expanding propagation of melon germplasm resources. According to the method, a plurality of sections of original daughters are obtained as propagules by cutting out the branches on the maternal body of a melon plant, and on the basis of rapidly culturing as many original daughters as possible, the rapid breeding of the melon germplasm resources is completed simply through a process of once reproductive growth and one generation of breeding. Compared with the prior art of multiple generation expanding propagation, the risk of biological mixing and mechanical mixing is significantly reduced, the breeding cost is greatly reduced, and the breeding time is shortened.
Owner:JILIN ACAD OF AGRI SCI
Artificial hair follicle, preparation method therefor and use thereof
The invention provides artificial hair follicle, a preparation method therefor and use thereof. The method comprises: transplanting human pluripotent stem cells into the skin of a heterologous embryoat the hair forming stage; continuously cultivating the embryo transplanted with the human pluripotent stem cells in a heterologous maternal body until the embryo is delivered; and isolating hair follicles in the skin of the embryo transplanted with the human pluripotent stem cells to obtain an artificial hair follicle. The artificial hair follicle obtained by the method according to the embodiment of the invention has a large number, the structural morphology is similar to that of the hair follicle in normal skin, and the artificial hair follicle can be used for hair follicle transplantationof different parts of the human body, such as scalp, eyebrow, beard, body hair, and the like; at the same time, the obtained artificial hair follicles are transplanted back to a pluripotent stem cellprovider without immunological rejection, and the safety is greatly improved.
Owner:SUN YAT SEN UNIV
Placenta microenvironment targeted delivery probe as well as preparation method and application thereof
ActiveCN114224870AStable structureCyclic stabilityNanomedicineColor/spectral properties measurementsAntiendomysial antibodiesTrophoblast
The invention discloses a placenta microenvironment targeted delivery probe as well as a preparation method and application thereof. A) a shell is a lipid bimolecular membrane which is modified by enzyme substrate polypeptide-PEG and is subjected to targeted disintegration under the action of an enzyme which is in contact with placenta tissue interstitial fluid and is highly expressed, and B) an inner core is a drug carrier which is modified by a marker antibody which is specifically and highly expressed on the surface of placenta trophoblast; and C) loading superparamagnetic ferroferric oxide SPIO nanoparticles, a small molecule drug for regulating and controlling the functions of placental trophoblasts, a therapeutic gene or a combination thereof in the drug carrier. The placenta microenvironment targeted delivery probe disclosed by the invention can effectively avoid non-specific drug absorption of other organs outside the placenta of a maternal body and a fetus, so that delivery and function regulation and control of a trophoblast specific drug in the placenta are realized.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Reduced glutathione fluorescent probe with pyrazoline as maternal body
InactiveCN103601679AHigh selectivityHigh sensitivityOrganic chemistryFluorescence/phosphorescenceFluorescenceFluorophotometry
The invention discloses a reduced glutathione fluorescent probe with pyrazoline as a maternal body. The probe is 2-(1, 5-diphenyl-4, 5-dihydro-1H-pyrazole-3-yl)phenyl acrylate. The probe provided by the invention can selectively interact with reduced glutathione, has a fluorescence enhancement effect, can be used for analysis through fluorophotometry and can realize trace detection of reduced glutathione. With high sensitivity, the reduced glutathione fluorescent probe is suitable for wide popularization.
Owner:SHANDONG UNIV
Calf gender-determined reproduction method
InactiveCN101766507AAchieve qualitative breedingIncrease varietyAnimal reproductionRural areaMedicine
The invention discloses a calf gender-determined reproduction method which is used for the artificial reproduction of calves. The technical scheme is that the pH value of the vaginal mucus of a maternal body is determined before mating; when the pH value is larger than 7, the born calves after mating are male calves; and when the pH valve is less than 7, the born calves after mating are female calves. The invention has the advantages that the gender-determined reproduction can be accurately realized, the development of the cattle raising industry is effectively promoted, the progress of the breed improvement is promoted and the economic benefit of cattle raisers is increased; and the technical measures are simple and feasible, and the popularization and the application in rural areas are facilitated.
Owner:赵有权
Genetic chromosome test management system, test management server, client terminal, genetic chromosome test management method, and program
InactiveUS20160378953A1Durable finishMaintain qualityBioreactor/fermenter combinationsBiological substance pretreatmentsBlood collectionManagement unit
The genetic chromosome test management system (10) used for a genetic chromosome test for testing an abnormality of a chromosome contained in fetus-derived nucleated red blood cells includes: an identification information acquisition unit (14) which acquires identification information of a maternal body; a blood collection date and time specification unit (16) which specifies a blood collection date and time; a storage unit (20) which stores the identification information of the maternal body and information of the blood collection date and time; a test progress detection unit (24) which detects a progress condition of a test until at least a specific step one step before a step which is determined as not being affected by removal of nuclei; and a management unit (26) which manages a progress of the test until at least the specific step is completed, based on the detected progress condition.
Owner:FUJIFILM CORP
Fetus electrocardiogram signal extracting method
ActiveCN104161508AReduce dependenceSmall amount of calculationDiagnostic recording/measuringSensorsPotential differenceAbdominal wall
The invention belongs to the technical field of biomedical signal processing, and particularly relates to a fetus electrocardiogram signal extracting method for extracting fetus electrocardiogram signals from mutually mixed electrocardiogram signals of a maternal body and a fetus. The fetus electrocardiogram signal extracting method comprises the steps that firstly, an electrode of test equipment is put on the abdominal wall of the maternal body, potential difference data caused by electrocardiogram conduction are recorded, multiple sets of data are recorded, and multiple paths of mixed electrocardiogram signals of the maternal body and the fetus are obtained; reference signals of the electrocardiogram signals of the maternal body are built, and then the electrocardiogram signals of the maternal body are extracted from the mixed electrocardiogram signals of the maternal body and the fetus through the reference signals; the components related to the extracted electrocardiogram signals of the maternal body are eliminated from the mixed electrocardiogram signals of the maternal body and the fetus, and therefore the purpose of extracting the fetus electrocardiogram signals is realized. The fetus electrocardiogram signal extracting method can effectively extract the fetus electrocardiogram signals from the mixed electrocardiogram signals of the maternal body and the fetus, is small in calculation amount, is low in complexity, is less dependent on parameters, is clear in extracted signals, and realizes the expectant purpose.
Owner:HARBIN ENG UNIV
Portable fetal heart rate monitoring equipment and fetal heart rate monitoring system
PendingCN113940676AReduce volumeMonitor ECG statusDiagnostic recording/measuringSensorsControl engineeringEmergency medicine
The invention provides portable fetal heart rate monitoring equipment and a fetal heart rate monitoring system. The portable fetal heart rate monitoring equipment comprises an electrocardio sensor and a host, wherein the host comprises a main control module, a power management module, a signal collecting front end, a motion monitoring module, a control module and a communication module; and the signal collecting front end is connected with the electrocardio sensor, and the signal collecting front end, the communication module, the control module, the motion monitoring module and the power management module are all connected with the main control module. The portable fetal heart rate monitoring equipment provided by the invention is small in size and can provide long-time data collection. The equipment is convenient to wear and does not interfere with the action of the user. The equipment can monitor the electrocardiogram states of the fetus and the maternal body at the same time, can monitor the motion state of the maternal body at the same time, and can report accidents to a remote cloud service platform in time.
Owner:江苏正心智能科技有限公司
Nanometer delivery system for regulating and controlling functions of microenvironment T cells as well as preparation method and application of nanometer delivery system
ActiveCN114306241APromote proportional changeImprove immune activityEnergy modified materialsGenetic material ingredientsMaternal bodyFetus fetus
The invention discloses a nano delivery system for microenvironment T cell function regulation and a preparation method and application thereof.The delivery system is of a core-shell double-layer structure, and an enzyme substrate polypeptide-PEG modified lipid bimolecular membrane which is disintegrated in a targeted mode under the action of high-expression enzyme in contact with placenta tissue interstitial fluid serves as a shell; a drug carrier modified by an important immunomodulatory cell helper T cell (Th) surface specific high-expression marker antibody in a placenta is used as an inner core, and superparamagnetic ferroferric oxide SPIO nanoparticles, a small molecule drug for regulating and controlling the function of the helper T cell in the placenta, a therapeutic gene or a combination thereof are loaded in the drug carrier. The nano delivery system for regulating and controlling the functions of the T cells in the microenvironment can effectively avoid non-specific drug absorption of other organs outside the placenta of the maternal body and a fetus, so that specific drug delivery and function regulation and control of helper T cells in the placenta are realized.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Gene modification method
ActiveCN109897867ARealize in vivo injectionReduce acquisition timeMicroinjection basedAnimal husbandryMaturation oocyteEmbryo
The invention provides a gene modification method. The gene modification method comprises the step that in-situ micro-injection of a gene modification reagent is conducted on internal immature oocytein a mode animal. The gene modification method is utilized, the micro-injection time is advanced to the period that ova are immature, a method of direct injection in a maternal body is adopted, the oocyte after injection is matured naturally in the maternal body, then discharged and fertilized, mutants with almost all cell genomes being edited can be obtained at the F0 generation, the phenotype consistent with the homozygous mutants and stably-expressed transgenic maps can be seen in injected contemporary embryos, compared with the prior art, the mutant obtaining time is shortened to 2-3 months, and large-scale screening work is not needed.
Owner:TSINGHUA UNIV
Aircraft landing device and method
The invention belongs to the technical field of aviation, and particularly relates to an aircraft landing device and method. The landing device comprises a subsidiary body and a maternal body, wherein the subsidiary body comprises a fixed-wing aircraft, a network connection platform, a connection groove, sensing and responding devices and a movable baffle; the maternal body comprises a multi-rotor aircraft, a service platform, a connection structure and alignment detection devices; the alignment detection devices detect the orientation of the subsidiary body, and meanwhile, the alignment detection devices position the sensing and responding devices of the subsidiary body precisely; when the subsidiary body needs to land, the maternal body lifts off, and the three alignment detection devices respectively are aligned with the three sensing and responding devices to achieve precise positioning; and the connection structure is embedded into the connection groove, the maternal body is connected with the subsidiary body, the maternal body starts a power system, and the maternal body carries the subsidiary body to land. The aircraft landing device and method can utilize the advantages of the multi-rotor aircraft, the multi-rotor aircraft is utilized to combine with the aircraft to manufacture an air runway for take-off and landing of the aircraft, construction of a runway needed by the aircraft is reduced, and popularization of the fixed-wing aircraft is facilitated.
Owner:FOSHAN SHENFENG AVIATION SCI & TECH
Method for on-site collection and fresh preservation of sheep placenta and amniotic fluid
InactiveCN103636737APrevent active ingredient changesMaintain nutrientsMeat/fish preservation by freezing/coolingFrozen storageAnimal science
A sheep placenta not only has rich nutritional value, but also has a cell immune function, a cell repairing function and the like, but active ingredients in the sheep placenta have significant change after the sheep placenta is separated from a maternal body and show a significantly decreasing tendency. The invention discloses a method for on-site collection and fresh preservation of the sheep placenta and an amniotic fluid. The method comprises the steps: preparing double interlayer collection bags each having an outer layer which is a cold medium; respectively filling the amniotic fluid and the sheep placenta into the collection bags for vacuum package; putting into an instant freezer for ultrarapid freezing, and carrying out low-temperature frozen storage; and thawing the frozen-storage amniotic fluid and the frozen-storage sheep placenta by running water or microwaves for follow-up development. The method prevents the change of the active ingredients of the amniotic fluid and the sheep placenta during the collection process, maximizes to maintain nutrient substances and the active ingredients of the amniotic fluid and the sheep placenta, and provides a basic guarantee for deep processing of the amniotic fluid and the sheep placenta. The method has short quick-freezing time, simple process and convenient operation, and is a new technology for retaining the maximum bioactive ingredients of the amniotic fluid and the sheep placenta.
Owner:杨公明
Method for improving meat flavor of filial generation by feeding parent population with low-protein feed
The invention aims to provide a maternal-body low-protein method for improving the meat flavor of offspring. The method takes protein as a main way and improves the nutritive value and meat quality of offspring chicken by changing the amount of feeding a maternal generation. According to fed daily rations in different protein levels (high protein level, normal level and low protein level), 96 egg-laying hens are divided into three daily ration groups at random; when the egg-laying rate of maternal bodies reaches 50 percent, artificial insemination is performed; when the egg-laying rate of the maternal bodies reaches a peak, people begin to collect hatching eggs; and the collected hatching eggs are incubated. The method has the function of improving the meat quality of chicken, wherein the low protein level of the daily rations for the hens can improve the meat flavor of the offspring, and does not change the muscular nutritive value of the offspring at the same time; in addition, the reduction of the protein level of the daily rations for the hens can not affect the liver health and functions of the offspring, but can save raising cost.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Placenta focus specific drug distribution and delivery system as well as preparation method and application thereof
ActiveCN114366819AStable structureCyclic stabilityPowder deliveryEnergy modified materialsAntiendomysial antibodiesTrophoblast
The invention relates to a placenta focus specific drug distribution delivery system and a preparation method and application thereof, and belongs to the technical field of chemical and biomedical engineering.The delivery system is of a core-shell double-layer structure and comprises an outer shell and an inner core; the shell is an enzyme substrate polypeptide-PEG modified lipid bimolecular membrane which is subjected to targeted disintegration under the action of an enzyme which is in contact with placenta tissue interstitial fluid and is highly expressed; the inner core is a drug carrier modified by a marker antibody with high specific expression on the surface of the placenta trophoblast, and superparamagnetic ferroferric oxide SPIO nanoparticles and a small molecule drug or / and a therapeutic gene for regulating and controlling the function of the placenta trophoblast are loaded in the drug carrier. The nano-drug delivery system disclosed by the invention can effectively avoid non-specific drug absorption of other organs outside the placenta of the maternal body and a fetus, so that delivery and function regulation and control of specific drugs of trophoblasts in the placenta are realized.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
A confinement nourishing milk shake powder and preparation method thereof
ActiveCN103999942BEfficient use ofPlay a role in weight controlMilk preparationIcing sugarSide effect
The invention discloses maternal nourishing milkshake powder and a preparation method thereof, and in particular relates to the milkshake powder which is convenient to eat and has an auxiliary protective effect on recovery of a maternal body, belonging to the technical field of special dietary food and milk product processing. The maternal nourishing milkshake powder is characterized by consisting of whole milk powder, skimmed milk powder, whey protein powder, brown powdered sugar, inulin, casein phosphopeptides, soluble soybean polysaccharides and lactoferrin. The maternal nourishing milkshake powder has the advantages that the effects of nutrition complementation and collaborative gain are fully achieved; the market blank is filled; the food, such as vegetables, fruits, millet and red beans, required by puerperae can be supplemented according to individual needs; the maternal nourishing milkshake powder is conveniently and safely eaten, provides comprehensive nutrition, can be favorable to the recovery of the maternal body, and has an auxiliary protective effect on the puerperae and infants; unwell symptoms, such as postpartum constipation and anemia, can be prevented and improved remarkably after the maternal nourishing milkshake powder is eaten; meanwhile, the immunity can be enhanced; the comprehensive health of the puerperae and the infants are maintained; the color, the taste, the stability and the like of the product do not have any adverse influence; hazards and side effects on bodies cannot be caused by taking the maternal nourishing milkshake powder normally.
Owner:李卫平
Fructus schizandrae maternal separation cultivation technology
InactiveCN106962008AIncrease productionImprove survival ratePlant cultivationCultivating equipmentsMaternal bodySchisandra chinensis
The invention discloses a fructus schizandrae maternal separation cultivation technology. The technology is characterized by including the following steps that firstly, planting is conducted, wherein a place with fertile soil is selected on a shady slope with the altitude of 950-1500 meters for planting; secondly, treatment is conducted in the fruit bearing stage, wherein when fructus schizandrae grow to the fruit bearing stage, compost soil which is 20-50 cm thick is arranged on the roots of fructus schizandrae fruits, so that the root separating seedlings take root; thirdly, segmentation is conducted, wherein when the fructus schizandrae grow to the cutting stage, the separating seedlings and maternal bodies are manually segmented, and the segmentation portions are tightened; fourthly, the separating seedlings are treated, wherein the segmented separating seedlings are transplanted and cultivated in a field; fifthly, the maternal bodies are treated, wherein the roots of the segmented maternal bodies are covered with treated compost soil. The technology greatly increases the yield and ensures the survival rate, the growth period is shortened, and the technology has a great significance in the fructus schizandrae cultivation technical field.
Owner:镇坪县草堂春生物制品有限公司
Uterine contraction detection device based on maternal physiological electric signals and method thereof
ActiveCN110974180AContraction suppressionSensorsMeasuring/recording heart/pulse rateAnimal scienceAnatomy
The invention discloses a uterine contraction detection device based on a maternal physiological electric signal and an acceleration sensor and a method thereof, and the device comprises an electrodewhich is in contact distribution with the abdominal body surface of a puerpera and obtains a body surface uterine myoelectric signal; a processor keeps electric signal transmission with the electrodes; the processor comprises a calculation and analysis system; the calculation and analysis system is used for extracting a uterine contraction trend curve from the body surface uterine electromyographysignals obtained by the electrodes and carrying out nonlinear decomposition and reconstruction on the uterine contraction trend curve through an EMD algorithm to obtain an accurate uterine contraction curve; and the scaling correction is carried on the uterine contraction accurate curve by integrating the maternal body position signal and the maternal heart rate data to obtain a final uterine contraction curve.
Owner:SOUTH SUZHOU MEDICAL TECH CO LTD
Microenvironment enzyme targeting combined antibody Fab cell targeting vector as well as preparation method and application thereof
ActiveCN114376974AImpact distributionImpact releasePowder deliveryOrganic active ingredientsTrophoblastSomatic cell
The invention discloses a microenvironment enzyme targeting combined antibody Fab cell targeting vector and a preparation method and application thereof.The targeting vector is of a core-shell double-layer structure, and an enzyme substrate polypeptide-PEG modified lipid bimolecular membrane which is disintegrated in a targeted mode under the action of high-expression enzyme in contact with placenta tissue interstitial fluid serves as a shell; a drug carrier modified by a marker antibody with high specific expression on the surface of placental trophoblast is used as an inner core, and superparamagnetic ferroferric oxide SPIO nanoparticles, small molecule drugs for regulating and controlling the functions of the placental trophoblast, therapeutic genes or a combination of the superparamagnetic ferroferric oxide SPIO nanoparticles, the small molecule drugs and the therapeutic genes are loaded in the drug carrier. The targeting carrier disclosed by the invention can effectively avoid non-specific drug absorption of other organs outside the placenta of a maternal body and a fetus, so that delivery and function regulation and control of specific drugs of trophoblasts in the placenta are realized.
Owner:中山大学南昌研究院
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