Placenta microenvironment targeted delivery probe as well as preparation method and application thereof
A microenvironment and placenta technology, applied in the fields of biomedical engineering and chemistry, can solve problems such as deficiency, and achieve the effects of reducing distribution and release, stabilizing structure, and reducing toxic and side effects
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Embodiment 1
[0047] Synthesis of S1, polyacetylimide grafted polyethylene glycol (PEG-PEI)
[0048] Polyethyleneimine-grafted polyethylene glycol (PEG-PEI) was synthesized by a two-step method. First, the terminal hydroxyl groups of monomethyl ether polyglycol were activated with carbonyldiimidazole, and then reacted with the amino groups of polyethyleneimine to generate PEG. -PEI. The specific operation is as follows: weigh monomethyl ether glycol (8.0 g, Mn=2 kDa) into a reaction flask, dry it in vacuum at 80° C. for 6 h, and add THF (60 mL) under an argon atmosphere to dissolve it. Weigh carbonyldiimidazole (CDI, 6.4g) and another reaction bottle, then slowly drop THF dissolved in mPEG-OH into the CDI bottle with a constant pressure dropping funnel, and stir the reaction overnight at room temperature. Distilled water (0.648 mL) was added to inactivate excess CDI, and stirring was continued for 30 min. Precipitate the solution into a large amount of cold ether, filter and dry in vacuo ...
Embodiment 2-4, comparative example 1-6
[0069] Compared with Example 1, Example 2-4 or Comparative Example 1-6 can be prepared by changing the dosage of polymer, drug and SPIO in Step S3 or omitting a certain step in Steps S3, S4, S5, S6, and S7 , see Table 1 below for details:
[0070] Table 1: Examples and comparative examples
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