The invention relates to a universal preparation method for an active site-electrode structure integrated air electrode. The universal preparation method is characterized in that various polymer microspheres having open internally-communicating hierarchical-pore structures are conjugated with active sites like noble metal groups, transition metal groups, and hetero atom-doped carbon groups in virtue of different treatment methods; the different treatment methods may be one or more selected from the group consisting of a carbon tetrachloride cross-linking method, a concentrated-sulfuric-acid sulfonation method, a carbon dioxide gas activation method, a dopamine coating method, an ammonia gas activation method, a polyaniline coating method, an in-situ precious-metal loading method, an in-situ transition metallide growth method and an in-situ heteroatom doping method. The universal method described in the invention can flexibly conjugate open internally-communicating hierarchical-pore electrode structures containing super-macro pores, macro pores, meso pores and micropores with a plurality of different highly-active catalytic sites by using appropriate methods, so the catalytic performance of the air electrode and the overall performance of a fuel cell and a metal-air battery are improved.