The invention relates to an Oral Delayed
Immediate Release formulation comprising a compressed core containing one or more active substances surrounded with a
coating, wherein release of active substance from the core is caused by rupture of the
coating after a definite
lag-time, said core comprising one or more
immediate release carriers and having no substantial swelling properties upon
exposure to
gastrointestinal fluids. The invention further relates to formulations containing an
Immediate Release formulation combined with one or more Oral Delayed
Immediate Release formulations with different
lag-times and to a method of preparing an Oral Delayed Immediate Release formulation.The Oral Delayed Immediate Release formulation may be used for the application of active substances whenever a certain
lag-time before release is advantageous, such as in be the case of anti-asthmatics, anti-emetics, cardiotonics, vasodilators, anti-vertigo and anti-meniere compounds, anti-hypertensives, sedatives, anti-depressants, anti-
anxiety compounds, cortico-steroids, general anti-inflammatory compounds, anti-inflammatory compounds for gastrointestinal use, anti-ulceratives, analgetics, anti-aritmics, anti-rheumatics, anti-arthritic compounds and anti-
angina compounds.The Oral Delayed Immediate Release formulation may also be used for the application of biological active compounds such as proteins, peptides, enzymes, vaccines and oligonucleotides.