Near-infrared second window emitted micro-molecular rear earth complex fluorescence probe and preparation method thereof

Abstract

The invention belongs to the technical field of biological materials and particularly relates to a near-infrared second window emitted micro-molecular rear earth complex fluorescence probe and a preparation method thereof. The near-infrared second window emitted micro-molecular rear earth complex fluorescence probe comprises a complex coordinated by DOTA (1, 4, 7, 10-tetraazacyclododecan-1, 4, 7,10-tetraacetic acid) and rear earth Ln(III) metal, a complex coordinated by DOTA-NHS (DOTA-n-hydroxysuccinimide) ester and rear earth Ln(III) metal, and a reaction product of Ln-DOTA-NHS and amino-PEG(polyethylene glycol)-folic acid. By changing the functional groups in macrocyclic polyamine structures without affecting the coordinating ability of macrocyclic polyamines and rear earth ions, the near-infrared second window emitted micro-molecular rear earth complex fluorescence probe achieves tumor targeting effects after being specifically combined with tumor surface receptors and meanwhile achieves surgical excision of under the guidance of a near-infrared window. According to the variety of receptors to be modified by the micro-molecular rear earth complex fluorescence probe, the micro-molecular rear earth complex fluorescence probe can specifically target various tumors to achieve antibody-antigen immunoreaction, and through pairing of base pairs of DNA (deoxyribonucleic acid) sequences, to achieve gene expression.

Description

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AI Technical Summary

Benefits of technology

This technology allows for chemical modification or binding between certain molecules that are involved with specific functions within cells called macrocystins (a type of organic compound). These modified structures have been found effective at deliver drugs into cancerous tissues through their interactions with other proteins like histones lining up DNA) by modifying them's interaction capabilities rather than directly interacting with these targets themselves.

Problems solved by technology

This patents describes different types of probes called fluoresceins or phospholipid nanocomplexes that help study cancer cells better than other organs like kidney stones. These probes emit signals at specific frequencies when excited by laser radiation, making them useful tools for medical purposes. However, they still suffer from certain drawbacks including limited biocompatibility, difficulty dissolving during use, lack of selectivity towards particular targets, short lifetimes, and potentially harmful effects upon healthy individuals who may come into contact with them.

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