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Compositions and methods comprising energy absorbing compoundfs for follicular delivery

a technology of compound and follicle, which is applied in the direction of microcapsules, dermatological disorders, drug compositions, etc., can solve the problems of leaving disfiguring scars, and achieve the effect of facilitating compound delivery and compound delivery

Inactive Publication Date: 2013-11-28
THE GENERAL HOSPITAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides methods for treating follicular skin diseases such as acne by applying a formulation containing a light absorbing compound to the skin. The compound can be delivered to the hair follicle, sebaceous gland, sebaceous gland duct, or infundibulum of the skin by mechanical agitation, acoustic vibration, ultrasound, alternating suction and pressure, or microjets, and then exposed to energy activation to treat the disease. The method can also improve the appearance of enlarged pores in the skin and facilitate delivery of the compound to a target volume within the skin by irradiating the skin with light pulses or applying low-energy laser pulses.

Problems solved by technology

Acne may be minor, where only a few comedones or papules are present, or it may be highly inflammatory and leave disfiguring scars.

Method used

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  • Compositions and methods comprising energy absorbing compoundfs for follicular delivery
  • Compositions and methods comprising energy absorbing compoundfs for follicular delivery
  • Compositions and methods comprising energy absorbing compoundfs for follicular delivery

Examples

Experimental program
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Effect test

example 1

Topical Delivery of Nanoshells to the Follicular Epithelium for the Treatment of Follicular Diseases

[0096]An example of massage as a mechanical means of follicular delivery is described. Nanoshell suspension tuned to 800-nm was massaged in an epilated pig skin in an in vivo live pig. Laser energy with parallel contact cooling was applied after wiping off the suspension on the top of the skin. A biopsy was taken, and routine histology was performed. A micrograph of the histology is shown at FIG. 1. Thermal damage to the follicular epithelium and part of the sebaceous gland is noted. Such damage is useful for the treatment of follicular diseases, such as acne.

example 2

Topical Delivery of Nanoshells to the Follicular Epithelium for Laser Hair Removal

[0097]In preparation for laser hair removal, a pig flank was epilated by waxing. Skin was subsequently heated, and a vacuum was applied to empty the follicular contents of the skin. Silica core: gold shell microparticles, of approximate dimensions of 0.150 micrometers diameter coated with PEG were then delivered by massaging. Skin was wiped to remove the material from the top of the skin. This was followed by pulsed laser irradiation at 800 nm. Samples were excised, fixed in formalin, and processed via routine histology (H&E staining). Thermal injury to the follicular structure was noted via histology.

example 3

Light-Pulse Induced Pressure Pulse Facilitated Delivery

[0098]A formulation containing a light-absorbing material is applied on top of skin. This is moved into the infundibulum of the infundibulo-sebaceous unit by methods known in the art, including but not limited to, passive diffusion, heating, mechanical assistance such as pressure pulsing, vibration, acoustic coils, ultrasound, nozzles or a combination of the above. Then, pulses of light are applied with a handpiece with an integrated cooling plate that can be pressed on to the skin. The first pulse(s) of light heat the material, resulting in expansion, with or without steam bubble formation. A pressure pulse is thereby created. Pressure is applied to the skin by the plate during the pressure pulse. Because the pressure cannot escape from the skin, the material flows through low resistance channels within the skin, such as the sebaceous gland duct, to reach the sebaceous gland. This pulse typically has short pulse duration, e.g.,...

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Abstract

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.

Description

RELATED APPLICATION DATA[0001]This application claims the benefit of U.S. provisional patent application Ser. No. 61 / 636,381, filed Apr. 20, 2012, the entire contents of which are incorporated herein by this reference.[0002]This application may contain subject matter that is related to that disclosed and claimed in U.S. patent application publication No. 2012 / 0059307 A2, published on Mar. 8, 2012, the entire contents of which are incorporated herein by this reference.BACKGROUND OF THE INVENTION[0003]Acne vulgaris is a follicular skin disease that is characterized by the appearance of comedones, papules, nodules, and cysts. Comedones are hair follicles that are blocked with a keratin plug. Open comedones, those in which the keratin plug is visible, form “black heads” and closed comedones form “whiteheads” that often progress to inflamed papules, nodules, and cysts. The presence of bacteria in a follicle attracts white blood cells to the follicle, which can cause an inflammatory respo...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K9/50A61K33/242A61K33/243
CPCA61K33/24A61K9/50A61K9/0009A61K9/0014A61K9/5115A61K41/0047A61P17/00A61P17/08A61P17/10A61P43/00A61K33/242A61K33/243
Inventor PAITHANKAR, DILIPBLOMGREN, RICHARDANDERSON, RICHARD ROXFARINELLI, WILLIAM A.DOUKAS-ANDERSON, APOSTOLOS G.
Owner THE GENERAL HOSPITAL CORP
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