The invention discloses an antibacterial active
peptide. An
amino acid sequence of a polypeptide molecule of the antibacterial active
peptide is Ac-RRPVPIIYCNRRKGRCQKM-NH2; a preparation method of theantibacterial active
peptide comprises the following steps: by taking Rink-
MBHA resin as a
solid phase carrier, and adding the Rink-
MBHA resin into a main reaction kettle and carrying out treatment;carrying out
amino acid condensation by adopting a linear synthesis mode, and performing
drying in a vacuum dryer after synthesis to obtain peptide resin; and
cracking the peptide resin to obtain a polypeptide crude product, and purifying the polypeptide crude product to obtain the antibacterial active peptide. The antibacterial active peptide disclosed by the invention is high in
antibacterial activity, has a remarkable
antibacterial effect when the concentration is 10mu g / ml, is wide in antibacterial spectrum, and has a remarkable
antibacterial effect on
escherichia coli,
staphylococcus aureus,
candida albicans and the like; the antibacterial active peptide destroys
cell membranes of
bacteria through a physical effect so as to achieve the antibacterial purpose,
drug resistance is not generated, and the antibacterial active peptide
raw material is low in price, easy to obtain, easy to prepare and produce and capable of bringing a better use prospect.