The invention relates to the field of
chemosynthesis, a trihydrate 3-aminopropyl amine ethyl
thiophosphoric acid(
amifostine)stable
crystal and a preparation method thereof. The method comprises the following steps: step one, according to the
molar ratio of between 1.01 to 1.0 and 1.2 to 1.0, N-(2-bromethyl)-1,3-
propane diamine bi-
hydrobromide and
sodium thiophosphate are dissolved in water, are added with a polar aprotic
solvent as an
accelerant and react at a temperature of between 10 and 40 DEG C; after reaction, the mixture is directly cooled to precipitate a coarse product of trihydrate
amifostine; step two, the coarse product of the trihydrate
amifostine obtained in the step one is subjected to primary recrystallization and purification, is dissolved in the water and is precipitated out through
methanol to obtain
anhydrous amifostine; and step three, the
anhydrous amifostine obtained in the step two is subjected to secondary recrystallization and purification, is dissolved in the water and is decolored through
active carbon; and the trihydrate amifostine
crystal is precipitated out through
ethanol. The purity of the
crystal is more than or equal to 99.5 percent; the content of mercaptan is less than or equal to 0.1 percent; the content of other relevant substances is less than or equal to 0.1 percent; and a product is stable and is suitable for scale production.