126results about How to "Has an immune boosting effect" patented technology

The invention provides compound probiotics fermented Chinese herbal medicine active health care liquid and a preparation method thereof. The health care liquid is prepared by the following raw materials: folium ginkgo, gingko pollen, fructus lycii, tea leaves, bacillus natto, saccharomyces cerevisiae, lactobacilli, acetobacter xylinum, bifidobactirium, white granulated sugar, brown sugar, defatted soy flour, honey, oligosaccharide, sodium chloride, deionized water and the like. The compound probiotics fermented Chinese herbal medicine active health care liquid integrates disease treatment and health care functions of several single products, contains Chinese herbal medicine active ingredients with the functions of preventing and treating hyperlipidemia, hyperglycemia and hypertension, preventing tumors and cancers, enhancing memory, protecting livers, improving immunity, preventing and treating coronary heart diseases, and also contains probiotics groups and metabolic products of the probiotics groups which can regulate balance in the stomach and intestines, resist aging, prolong the life, facilitate digestion, expel toxin for beauty, and prevent and treat thrombi, constipation and diarrhea. The health care liquid integrates health care and treatment, is very wide in market prospect, and conforms to the existing medical viewpoint of people that the prevention, health care, treatment and recovery are combined.

The present invention discloses an antistress health-care preparation for shrimps and crabs. Its composition includes (by wt%) 70%-90% of glucose, 0.5%-1% of rhubarb, 0.5%-1% of garlic, 0.3%-0.5% of astragalus root, 0.3%-0.5% of forsythia fruit, 0.3%-0.5% of vitamin C and 0.3%-0.5% of vitamin E, and the rest is diluent. It can raise immunity and antistress power of aquiculture animals of shrimps and crabs, and can promote their growth. Said invention also provides the application method of said health-care preparation.

The invention discloses a cationic liposome, comprising cationic lipid, neutral phospholipid, polyethylene glycol derivatived phospholipid and mannose or mannan oligosaccharide, wherein a shell-shaped phospholipid bilayer is formed by phospholipid molecules in the the cationic lipid, the neutral phospholipid and the polyethylene glycol derivatived phospholipid; and mannose- or mannan oligosaccharide- modified polyethylene glycol derivatived phospholipid is formed by connecting the mannose or the mannan oligosaccharide with one end of the polyethylene glycol derivatived phospholipid. By adding the mannose- or mannan oligosaccharide- modified polyethylene glycol derivatived phospholipid, targeting property and enrichment in lymph glands of antigen-presenting cells are increased; the cationic liposome has an immunologic enhancement effect; and the immune efficacy of liposome-encapsulated vaccines can be increased. The invention also provides a preparation method of the cationic liposome.

An application of indole-2.3-bione in preparing the antiviral medicine for HIV, influenza virus, hemorrhagic virus and herpes simplex virus and the immunopotentiator is disclosed.

A Chinese medicine for preventing and treating the bacterial and viral diseases of aquatic animals is prepared from 12 Chinese-medicinal materials including astragalus root, Chuan-xiong rhizome, tangerine peel, rhubarb, etc.

The invention discloses a feed additive with immunity enhancement function, a preparation method and an application thereof. The feed additive comprises the following raw materials in parts by weight: Milkvetch root 10-25, isatis root 10-25, Rhizoma Atractylodis 10-25, honeysuckle flower 10-25, Cordyceps Polysaccharide 10-20, Divaricate Saposhnikovia root 5-10, Atractylodes Rhizome 5-10, and transfer factor 3-5. The Milkvetch root, isatis root, Rhizoma Atractylodis, honeysuckle flower, Cordyceps Polysaccharide, Divaricate Saposhnikovia root and Atractylodes Rhizome are compounded to form a traditional Chinese medicine composite, and then the traditional Chinese medicine composite is mixed with the transfer factor to obtain the feed additive. The feed additive is safe, non-toxic, and environmentally friendly without residues. The feed additive can enhance the immunity of livestock and poultry, effectively prevent and treat bacterial and viral diseases of livestock and poultry, increase the feed intake of piglets, promote the growth of piglets, and improve the growth performance of piglets and the feed conversion ratio.

The present invention is a medicine for treating infantile anorexia, especially is a medicine prepared by mixing biological preparation and Chinese traditional medicine for treating infantile anorexia. Its component mainly includes Alpha-mannan peptides 10-40%, and invigorating vital energy strengthening the spleen Chinese traditional medicine 60-90%. Its component also includes Alpha-mannan peptides 10-40%, invigorating vital energy strengthening the spleen Chinese traditional medicine 30-60%, and regulating vital energy strengthening the spleen resolving dampness Chinese traditional medicine 10-40%. Its component also includes Alpha-mannan peptides 10-40%, invigorating vital energy strengthening the spleen Chinese traditional medicine 10-40%, regulating vital energy strengthening the spleen resolving dampness Chinese traditional medicine 10-30%, and promoting blood and qi circulation Chinese traditional medicine 10-40%. The medicine for treating infantile anorexia is a Chinese Western composite preparation, combines the current medicine with traditional medicine scientifically, exerts their cooperating function, and has full comprehensive curative effect for infantile anorexia, and has no toxic and side effects.

The invention discloses multi-strain co-immobilization fermented mulberry fruit vinegar and a preparation method thereof. The preparation method comprises the steps of mulberry fruit selecting, washing, juicing, enzymolysis, filtering and centrifugation, ingredient adjustment, pasteurization, cooling, co-immobilization alcoholic fermentation, immobilization acetic bacterium fermentation, purifying, filtering, sterilization, ultrafiltration membrane purifying and filling to obtain a finished object. According to the multi-strain co-immobilization fermented mulberry fruit vinegar and the preparation method thereof, the problems that a large number of mulberry fruits are mature in the mature season, storage is hard, traditional fruit vinegar fermentation operation is complex, and strains are prone to be inactivated can be effectively solved. The mulberry fruits can be subjected to batch fruit vinegar production, the production period is shortened, the production capacity is improved, the prepared mulberry fruit vinegar is clear and transparent, stable in color and amaranthine, and has the special faint scent of the mulberry fruits, and the taste is gentle and mellow. Compared with traditionally fermented fruit vinegar, the fragrance and ingredients are both obviously improved. The advantages of the healthcare effects of enriching blood and nourishing yin, moistening the intestines, delaying aging, blacking hair and improving eyesight, improving skin blood supply and the like are achieved.

The invention discloses an immunity-enhanced nutrient meal and a preparation method thereof. The immunity-enhanced nutrient meal comprises the following raw materials in percentage by weight: 10-60% of black grain puffing powder, 5-20% of sesame oil, 10-30% of bean powder, 5-20% of dextrin, 5-20% of sugar powder, 1-10% of longan powder and 1-5% of ganoderma spore. The nutrient meal provided by the invention can be used conveniently and quickly and can be accepted easily by consumers. The immunity-enhanced nutrient meal which is prepared by taking black rice, black beans, black sesame, longan and the like as raw materials and adopting the modern food processing technology has delicate taste and specific fragrance, simultaneously contains various functional components beneficial to the human body, can be used as a leisure food with good health-care effect, and can also be used as a dietary supplement for enhancing the immunity of the organism.

The invention relates to traditional Chinese medicine compound polysaccharide with a function of synergistically enhancing humoral and cellular immunity. The traditional Chinese medicine compound polysaccharide comprises the following components in parts by mass: 25 parts of lentinan, 50 parts of astragalus polysaccharide and 125 parts of odonopsis pilosula polysaccharide. The optimal dosage of the traditional Chinese medicine compound polysaccharide for oral administration of a mouse is 1 g per kilogram of body weight per day, and the mouse is continuously dosed for 7-10 days; the optimal dosage of the traditional Chinese medicine compound polysaccharide of a pig is 0.111 g per kilogram of body weight per day, and the pig is continuously dosed for 14-21 days. The three polysaccharides are scientifically and reasonably matched and combined to generate complementary and synergetic enhancement functions, the formed polysaccharide composition can comprehensively recover and enhance the immunity of organism, thereby having an obvious immunity enhancement effect, and the components of the traditional Chinese medicine compound polysaccharide are common raw medicinal materials, thereby being good in safety and free of toxic side effect.

The invention relates to a compound metagen solid beverage and a preparation method thereof. The solid beverage is prepared from the following components in percentage by mass: 15-20% of sulforaphane, 20-25% of sodium butyrate, 25-30% of metagen solid powder, 18-22% of an adhesive, 4.5-6.0% of a sweetening agent and 3.5-6.0% of a sour agent, wherein the metagen solid powder comprises lactobacillus paracasei G15 and Q14 powder, lactobacillus rhamnosus powder and bifidobacterium powder; and the four kinds of lactobacillus powder are obtained by drying supernatants of respective bacilli. The metagen solid beverage is especially suitable for crowds with special requirements, such as crowds with hyperlipidemia, crowds with fatty liver and crowds with weight loss.

The invention relates to agaricus bisporus polysaccharide with immunological activity. The agaricus bisporus polysaccharide is heteropolysaccharide consisting of ribose, rhamnose, arabinose, xylose, mannose, glucose and galactose, wherein the mole mass ratio of ribose to rhamnose to arabinose to xylose to mannose to glucose to galactose is 2.08:4.61:2.45:22.25:36.45:89.22:1.55. The preparation method comprises the following steps: carrying out water bath on agaricus bisporus; carrying out ethanol precipitation on extract with ethanol; carrying out deproteinization on ethanol sediments by using a Sevag method; performing ion exchange column chromatography on the obtained crude polysaccharose anion exchange padding; eluting with distilled water, and freeze-drying; and carrying out gel chromatography, eluting with distilled water, and freeze-drying, so as to obtain the agaricus bisporus polysaccharide. The polysaccharide has the characteristic of immunologic enhancement, can be used as an adjuvant therapy medicament for hypoimmunity diseases such as tumour or used as functional health care products and foods which have the effect of improving the immunity.

The invention provides a water-in-oil-water type vaccine adjuvant and application thereof. According to the technical scheme, ingredients which conform to large production demands and have immunopotentiation are preferred, according to a controlled release principle of a water-in-oil-water type microsphere, an adding mode is designed, thus the water-in-oil-water type vaccine adjuvant more effectively directly acts on an immune cell, and the immune potency is improved. Compared with an regular adjuvant in the prior art, the prepared water-in-oil-water type vaccine adjuvant has reasonable controlled release, target and an isolation characteristic, and after poultry is injected with a vaccine, the water-in-oil-water type microsphere timely metabolizes and breaks so as to comprehensively motivate a poultry lymphocyte to generate an antibody. An immune reinforcing agent with a heavy water phase can be lastingly and slowly release in a subsequent immune cell infiltration process to make bioavailability of the immune reinforcing agent maximize, it is shown that an injected part is well absorbed, an injected animal fast generates immunoprotection, and not only short-term immunity can be induced, but also long-term immunity can be induced.

An interleukin-2(IL-2) gene of chicken is disclosed. An eukaryon expression plasmid containing said IL-2 gene is also disclosed, which uses pC as eukaryon expression vector. An immunopotentiator for fowls' vaccine is also disclosed, which is the aqueous solution of said eukaryon expression plasmid or the chicken's interleukin-2 protein expressed in eukaryon cell or animal body. Said immunopotentiator for fowls' DNA vaccines features high bioactivity, low cost and high effect to induce the immune response of cell and body fluid. It also elongate immune duration and reduce the dosage of vaccine.

The invention specifically discloses a microbial inoculant, in particular to a microbial inoculant prepared from swine borne bacillus licheniformis YHSH-02 and the application thereof in livestock breeding. The culture is preserved in CGMCC, 3#, Yard #1, West Beichen Road, Chaoyang District, Beijing, with the preservation number of CGMCC NO. 15454 and the preservation date of 15th, March, 2018. The bacillus licheniformis YHSH-02 is separated from a swine intestinal tract, can generate rich lipopeptides bacilli, antifungal proteins and the like, and can inhibit escherichia coli, pseudomonas aeruginosa, enterococcus faecalis, enterobacter cloacae, pseudomonas aeruginosa, proteusbacillus vulgaris, staphylococcus aureus, salmonella and clostridium. The bacillus licheniformis YHSH-02 obtained from the swine intestinal tract is a biological control potential culture which is high in preventing and treating efficiency and wide in preventing and treating range and can promote growth obviously,and has a good application and development prospect in non-resistant breeding.

The invention discloses compound indigowoad root oral liquid for improving poultry immunity and a preparation method thereof and aims at providing compound indigowoad root oral liquid for improving organism immunity and increases vaccine immunity effect and a preparation method thereof. Each 100 liters of the oral liquid comprises the following components: 0.5 to 20kg of indigowoad root amylose, 0.5 to 20kg of astragalus amylose raw material medicament containing 50 percent of astragalus amylose, 0.5 to 10kg of epimedium amylose raw material medicament containing 50 percent of epimedium amylose, 0.5 to 10kg of morinda extract, 50g of potassium sorbate and the balance of injection water. In the method, an amylose component with immunologic enhancement effect is selected from an indigowoad root medicinal material and mixed with restorative Chinese medicaments with the same immunologic enhancement effect, such as astragalus, epimedium and morinda, to produce a synergetic effect to enhance treatment effect. The oral liquid has good treatment effect on low immunity of poultry caused by disease or breeding conditions and can strengthen immune effect of a vaccine.

The invention belongs to polysaccharide with immunological activity, in particular to a franchet groundcherry fruit stem polysaccharide with immunological activity and a preparation method thereof. The method comprises the following steps of: extracting through a water immersion method; precipitating water immersion liquor extract; deproteinizing by using an enzyme method in combination with a Sevage method; drying to obtain rough polysaccharide; eluting with physiological saline; freeze-drying to obtain polysaccharide Q-WSP; and further purifying through HPLC (High Performance Liquid Chromatography) to obtain WSP (Water Soluble Polysaccharide). The molecular weight of the WSP obtained by using the method is about 7,000Da through HPLC measurement and the components are uniform. Monosaccharide components obtained through gas chromatographic analysis are Rha, Ara, Gal, Glc and GalA. The franchet groundcherry fruit stem polysaccharide has an immunological enhancement effect and can be used for foods and health-care products for improving the immunologic function of the organism. The preparation method is simple and reliable. The franchet groundcherry fruit stem has a wide source and is changed into things of value through development and utilization of the franchet groundcherry fruit stem polysaccharide.

The invention relates to a preparation method of a radix tetrastigme polysaccharide particle with an antitumor function. Radix tetrastigme polysaccharide is the active component, and other pharmaceutical auxiliary materials such as sustained release material, filling agent, adhesive, lubricant, and the like, are added to prepare the particle. Various transplantation tumor mouse models and in-vitro lymphocyte proliferation assay are used to evaluate the effect of radix tetrastigme polysaccharide particle on preventing tumors and enhancing immunity, the effect is good; compared with chemotherapeutic drugs, the side and toxic effects are less, and thus the radix tetrastigme polysaccharide particle has a good application prospect in antitumor aspect. The radix tetrastigme polysaccharide particle is user-friendly, can be directly swallowed or dissolved into water and then eaten, is bad in dustability, adhesiveness, and hygroscopicity, and has a stable drug content.

A Chinese medicine in the form of capsule, stable, particle, or oral liquid for treating pulmonary heart disease is prepared from 3 Chinese medicinal materials including astragalus root, red peony root and psoralea fruit through decocting twice (each time for 1 hr.), filtering, concentrating up to relative density of 1.05-1.15 at 80 deg.C, depositing in alcohol standing still for 24 hr, recovering alcohol, continuously concentrating up to relative density of 1.35-1.40 at 80 deg.C concentrating, mixing with red peony root powder, stirring, drying, pulverizing and granulating.

The invention relates to the technical field of health-care products, specifically to an oyster peptide buccal tablet and a preparation method thereof. The oyster peptide buccal tablet comprises the following components in parts by weight: 10-20 parts of oyster peptide, 5-10 parts of cordyceps militaris, 1-5 parts of ginseng, 2-6 parts of rhizoma polygonati, 4-8 parts of sea buckthorn, 3-6 parts of mulberry, 2-6 parts of Chinese yam, 5-10 parts of Chinese wolfberry, 0.5-3 parts of taurine, 2-6 parts of a flavoring agent and 1-3 parts of an adhesive. The oyster peptide buccal tablet provided bythe invention is convenient to be carried and taken, and has more comprehensive effects. The preparation method for the oyster peptide buccal tablet comprises the following steps: pretreatment of auxiliary materials; mixing and granulating; drying and tabletting. According to the preparation method provided by the invention, substances of the oyster peptide buccal tablet can be more easily absorbed by the human body; and preparation is simple.

The invention provides a transdermal infusion paste preparation for enhancing immunity and a preparation method thereof and relates to a preparation for enhancing the immunity and a preparation method thereof. The transdermal infusion paste preparation for enhancing the immunity is processed by using astragalus, cattail pollen, glossy privet fruit, Chinese angelica, malaytea scurfpea fruit, Indian buead, safflower, pseudoginseng root, tuberfleece flower root, fiveleaf gynostemma herb, indigowoad root, heartleaf houttuynia herb, sweet wormwood herb, nori, leaf of common fig, agaricus, champignon, tremella, hericium erinaceus, lucid ganoderma, royal jelly and propolis as raw materials and by a specific process. The transdermal infusion paste preparation can enhance human immunity, is suitable for senior, children, sick and disabled people with low immunities, has adjuvant therapeutic effect on recurrent diseases caused by low immunity, such as bronchopathy, asthma, allergic disorders, tumor and the like, and is suitable for people with low immunities.

The invention discloses a composition for strengthening the immunity function of an organism and a preparation method thereof. The composition is mainly prepared from the following raw materials in parts by weight: 67-201 parts of glossy ganoderma spore powder, 33.5-100.5 parts of astragalus membranaceus extracts, 25-75 parts of glossy privet fruit extracts, and 17.5-52.5 parts of turmeric extracts. A modern preparation technology is used, and an advanced quality control method is used, so that products are safe, stable and controllable. Animal experiments prove that compared with a preparation made of single glossy ganoderma spore powder and a preparation made of single astragalus membranaceus extracts, the composition disclosed by the invention has more excellent effects of strengthening the immunity of the organisms under the condition of the same dosage, and in addition, the composition does not have any toxic or side effects, so that the composition has higher development and utilization values and market application prospects.

The invention provides a method for preparing probiotics and ginkgo pollen oral solution, which comprises the following steps of: a, putting fresh ginkgo pollen into water, and performing wall breaking treatment on the ginkgo pollen to obtain wall-broken ginkgo pollen; b, respectively inoculating two probiotics of lactobacillus rhamnosus and lactobacillus acidophilus into an MRS liquid seed culture medium, and standing for culture at the temperature of between 30 and 37 DEG C to obtain probiotic seed liquor; c, mixing the wall-broken ginkgo pollen I the step a, sugar, sodium chloride and sodium glutamate, dissolving by adding deionized water, and performing high temperature sterilization to obtain a fermentation medium; and d, combining the two kinds of probiotic seed liquor in the step 2 in a ratio of 1:1, inoculating into the fermentation medium in the step 3 according to 1 to 3 percent of the total inoculum size, sealing by a plastic film, standing for anaerobic culture until the pH of the fermentation medium is reduced to 3.0-3.5, filtering by using gauze, and filling under the aseptic condition to obtain the product.

The invention discloses an oral donkey-hide gelatin preparation and a preparation method thereof, and belongs to the technical field of production of traditional Chinese medicines. The oral donkey-hide gelatin preparation comprises ultrafine donkey-hide gelatin powder, rock sugar, soybean oil, tea oil, yellow rice wine, Jerusalem artichoke, fish bone meal, Radix Astragali, wolfberry fruits, chitosan and a slow release assistant. The preparation method comprises the following steps: preparing a dissolved gelatin solution, blending the dissolved gelatin solution, extracting effective traditionalChinese medicinal health components from the Jerusalem artichoke, Radix Astragali and wolfberry fruits, adding the chitosan to ensure the clearness of the preparation, adding the fish bone meal to supplement calcium element, and adding the slow release assistant to improve the absorption rate of nutrients in the oral donkey-hide gelatin preparation by using the drug effect slow release effect ofthe slow release assistant. The oral donkey-hide gelatin preparation prepared in the invention has an excellent drug absorption efficiency.

The present invention provides a separating and purifying method and an application of codonopsis pilosula oligosaccharides. Inventors find that the codonopsis pilosula oligosaccharides (CPO) can regulate immune activity through a MAPK signaling pathway in vivo and can also regulate macrophage immune activity through the MAPK signaling pathway in vitro.

The invention relates to a novel strain, Lactobacillus fermentum strain, and a use thereof. Specifically, novel Lactobacillus fermentum PL9988, novel Lactobacillus fermentum PL9037, novel Lactobacillus fermentum PL9038, novel Lactobacillus fermentum PL9039 and novel Lactobacillus fermentum PL9040 strains, isolated from adults in a longevity village, and culture fluids thereof: have no antibiotic resistance transfer; have excellent intestinal cell adhesiveness, acid resistance and bile resistance; inhibit harmful pathogenic organisms in intestines; and have an immunity-enhancing effect, an endotoxin shock suppression effect and an antioxidant effect. In particular, Lactobacillus fermentum PL9988 strain significantly satisfies all of the above-mentioned conditions as a probiotic, and thus can be effectively used as a probiotic for intestinal health and defecation improvement and enhancement, or as a health food.

The invention discloses a special clinical nutritional composition for autistic disorder. The special clinical nutritional composition is prepared from the following components according to the weights ratio: 18 to 26 g of protein, 0 to 1 g of fat, 20 to 40 g of carbohydrate, 5 to 15 g of dietary fiber, 0.4 to 0.7 g of major element, 0.1 to 0.4 g of microelement, 0.1 to 0.25 g of probiotics, 1 to2 g of a natural plant compound, 0.5 to 5 g of a component both used as medicine and food and 0.05 to 2 g of a new resource food. The invention further provides a preparation method of the clinical nutritional composition. The clinical nutritional composition provided by the invention can be used for alleviating and improving corresponding symptoms of the autistic disorder from the pathogenesis; meanwhile, the clinical nutritional composition also enhances the self-immunity of children with the autistic disorder and promotes normal growth and development, and nutrient absorption of the children with the autistic disorder, so that a nutrient assisting function on clinical treatment is realized.

A health-care food for regulating immunity and resisting oxidation is prepared from pine needles, ophiopogon root and starch or beta-cyclodextrin through extracting the extract of pine needles or squeezing the pine needle to obtain juice, extracting the active components from ophiopogon root, proportional mixing, and adding starch or beta-cyclodextrin.

The invention relates to the field of immunology, and in particular, relates to a vaccine diluent, wherein the vaccine diluent comprises the raw materials: water for injection, a polymer, and an immunoenhancer optionally added. The preparation method of the vaccine diluent comprises the steps: weighing the raw materials, putting to the bottom of a stainless steel high-pressure reactor, putting a magneton, sealing, and putting the reactor into a water bath with magnetic stirring; setting the water bath temperature, starting up a single-cylinder injection pump, charging carbon dioxide to the pressure required in an experiment, stopping stamping, closing a reactor valve, keeping the internal pressure unchanged, and setting the stirring rate; and after placing at constant temperature in waterbath for a certain time and reaction is performed, relieving the pressure, and thus obtaining the vaccine diluent. The diluent combination after supercritical carbon dioxide treatment is easy for industrialized production of vaccines, and is safe and effective. The prepared diluent can be applied not only to an antigen of a live vaccine, but also to an antigen of an inactivated vaccine or an antigen of a synthetic peptide vaccine.

The invention discloses a mushroom multielemtent functional drink and a preparation method thereof. The drink mainly comprises the following components in parts by weight: 0.15-95 parts of fresh mushroom, 0.1-20 parts of poria cocos, 0.1-20 parts of astragalus mongholicus, 0.1-20 parts of radix polygonati officinalis, 0.1-20 parts of Chinese wolfberry, 0.1-20 parts of hawthorn and 0.1-20 parts of pawpaw. The mushroom multielemtent functional drink is prepared by the method comprising the following steps: adding bee honey, maltitol, protein sugar, lactic acid, citric acid, sodium carboxymethylcellulose, carrageenan, xanthan gelatin, sodium citrate, sodium pyrophosphate, emulsified silicon oil and nisin to the traditional Chinese medicine fresh mushroom juice prepared from the components; evenly stirring the components; adding purified water to dilute solution concentration until 75-85% of the original solution is obtained. The drink in the invention can adjust blood fat, assist to regulate blood sugar level and inhibit cancers, and improve digestive function; in addition, the drink in the invention can be a healthy drink for improving immunity and strengthening physique for healthy persons and has the advantage of unique sweet and sour flavor and faint scent taste.