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792 results about "Immunopotentiation" patented technology

An Immunopotentiation Effect involves stimulation of biologic molecules and complexes, or cellular, cell, or tissue components of a normal immune response.

Compounds for immunopotentiation

Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed. In a preferred embodiment benzopyrimidine derivatives such as ZD-6474, MLN-518, lapatinib, gefitinib or erlotinib are used.
Owner:NOVARTIS VACCINES & DIAGNOSTICS INC

Chinese herbal medicine biological feed additive for livestock and preparation method of Chinese herbal medicine biological feed additive

InactiveCN104824373AGood curative effectSolve the problem of not eatingAnimal feeding stuffBiotechnologyAnimal science
The invention relates to a Chinese herbal medicine biological feed additive for livestock and a preparation method of the Chinese herbal medicine biological feed additive. The prepared Chinese herbal medicine biological feed additive for the livestock comprises the following raw materials in percentage by mass: 20% of probiotics, 10% of an enzyme preparation, 50% of traditional Chinese medicines, 10% of amino acids, 4% of vitamins, 1% of micro elements, 1% of an immunopotentiator, 1% of bacitracin and 3% of glucose. The preparation method comprises the following steps: firstly carrying out expanding culture to revive the probiotics, fermenting the probiotics for 2 days so as to obtain probiotics fermentation liquor; placing the traditional Chinese medicines into the probiotics fermentation liquor for fermentation; and finally mixing the dried fermentation products with other raw materials so as to obtain the Chinese herbal medicine biological feed additive for the livestock. The prepared Chinese herbal medicine biological feed additive for the livestock disclosed by the invention has the advantages of improving the immunity, increasing the utilization rate of the feed, improving environment and the like.
Owner:RUZHOU DEJIN FODDER SALES CO LTD

Use of cell adhesion inhibitor for the mobilization of antigen presenting cells and immune cells in a cell mixture (AIM) from the peripheral blood and methods of use

Disclosed is a method to recover an antigen presenting cells (APCs) and immune cells rich mixture (AIM) from peripheral blood mononuclear cells (PBMC) mobilized with one or more cell adhesion inhibitors for the preparation of an AIM vaccine or an AIM adoptive immunotherapy preparation. In addition, AIM mobilization can be enhanced by priming, simultaneously or in sequence, one or more of a combination of different chemical compounds, cytokines, hormones, growth factors, etc. The interaction of chemokines and chemokine receptors enable tumor cells attachment or in close proximity to antigen presenting cells and immune cells which possess similar receptors in a micro niche environment. Severing the chemokine/chemokine receptor linkage by a cell adhesion inhibitor will release these specifically primed cell mixtures into the peripheral blood. The collection of these cells from the peripheral blood has never been described and is the basis of this invention. AIM cells can either be used alone or better still, be induced into more target specific preparations with additions, modifications and incubation, pre or post cell adhesion inhibitors mobilization, with vaccines, different target specific antigens, peptides, chemotherapeutic agents, oncolytic viral therapeutic agents, cytokines, co-stimulatory molecules, anti-regulatory T cell therapeutic agents, anti-CTLA4, anti-PD1 molecules and other methodologies of immunological enhancement known to the art. The AIM vaccine or AIM adoptive immunotherapy preparation can then be used, but not limited to, the treatment of cancer and other diseases.
Owner:YEUNG ALEX WAH HIN +1

Production and use for taxol and muramic acyl dipeptide conjugate substance of immune reinforcer

Production of paclitaxel and muramic acid dipeptide conjugale as immunopotentiator and its use are disclosed. The process is carried out by combination of solid-phase chemistry and liquid-phase chemistry. It improves water solubility of paclitaxel.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI

Nibea albiflora richardson larvae and juvenile microcapsule feed, as well as processing preparation and feeding method thereof

The invention provides a nibea albiflora richardson larvae and juvenile microcapsule feed which is prepared from white fish meal, euphausiid meal, squid meal, fish protein hydrolysate, feed yeast, alpha-starch, soybean lecithin, papain, fish oil, composite vitamin, composite mineral substance, binder, immunopotentiator, phagostimulant and the like. By adopting the innovated prescription and processing process, the microcapsule feed can fulfill the requirement for nutrition of larvae and juvenile growth, has the advantages of comprehensive nutrition, good palatability, high water stability, low cost and the like, can be produced in batches, is convenient for storing, transporting and feeding, is suitable for industrial breeding production, and adopts a corresponding feeding method, so that the survival rate of nibea albiflora richardson is greatly improved, the shape of the nibea albiflora richardson is increase. The nibea albiflora richardson larvae and juvenile microcapsule feed is suitable for large-scale popularization and application.
Owner:MARINE FISHERIES RES INST OF ZHEJIANG

Injection liquid of thymic peptide alpha 1 and preparation method thereof

Disclosed is a novel preparation of Thymosin alpha-1, which comprises Thymosin alpha-1, medicinal adjuvant and water for injection. The prepared Thymosin alpha-1 injection can be used as an immunity enhancement medicament for the treatment of chronic hepatitis B (HBV), hepatitis C (HCV), hepatocytecancer, melanocarcinoma, infectious disease, self-immune disease and malignant tumor.
Owner:CHENGDU SHENGNUO BIOPHARM

Beta-1,3/1,6-glucan, preparation method therefor, and application thereof in preparing immune enhancement and anti-tumor medicine and functional food

The present invention provide a beta-1,3 / 1,6-glucan, a preparation method therefor, and application thereof in preparing immune enhancement and anti-tumor medicine and functional food. The preparation method comprises: drying and milling antarctic brown algae; after degreasing, water extracting, calcium chloride precipitating and anion exchanging resin purification, obtaining glucan with a beta-1,3-glucose main chain and a beta-1,6-glucose branched chain, wherein a molecular weight thereof is between 5-50 kDa. The beta-glucan prepared by the present invention has an immune enhancement activity, which is indicated by swallow of neutral red by in vitro macrophages and an NO release promoting experiment, and has a tumor growth inhibiting effect and a tumor metastasis inhibiting effect which are indicated by an in vivo animal experiment. According to the present invention, beta-1,3 / 1,6-glucan is prepared by using the antarctic brown algae; is characterized in richness and readily availability of raw material sources, simple preparation process, high product purity, strong bioactivity and easiness for industrialization; and has a prospect of being developed into immune enhancement and anti-tumor medicine.
Owner:MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD

Immunity enhancing agent, inactivated vaccine, and preparation method thereof

The invention provides an immunity enhancing agent, an inactivated vaccine, and a preparation method thereof. The invention relates to the field of biopharmaceutical. The immunity enhancing agent comprises 0.1-21mg/mL of monophosphoryl lipid A, 1.5-125mg/mL of muramyl dipeptide, and 0.7-4.5mg/mL of beta-glucan. The invention also provides the inactivated vaccine comprising the immunity enhancing agent, and a preparation method of the inactivated vaccine. According to the invention, the immunity enhancing agent is mixed with an inactivated antigen solution, such that a water-phase solution is obtained; and the water-phase solution is mixed with an oil-phase solution, such that the inactivated vaccine is obtained. According to the immunity enhancing agent provided by the invention, with a synergetic effect of the components, body immunity level can be improved, and immune response to antigen can be improved, such that antibody level after immunization can be increased, immune window period can be shortened, and vaccine immunization effect can be enhanced. According to the inactivated vaccine comprising the immunity enhancing agent, antibody level after immunization is high, a protection period is long, and immunization window period is short.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES +1
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