705 results about "Signal pathway" patented technology

The present invention provides a tablet computer and a docking station assembly. This docking station comprises a docking assembly for positioning with three degrees of freedom and having a data connector for mechanically supporting and interfacing with the tablet computer. A support member couples the docking assembly to an expansion base. The base includes a number of ports for interfacing with a variety of peripheral devices or power supplies. These varieties of ports mount to a printed circuit board contained within the expansion base. A flexible printed circuit (FPC) combines the signal pathways for the variety of ports, allowing the signal pathways to travel from the printed circuit board and to the data connector. The tablet computing device has a plurality of contact or touch points positioned on the right and left edges of the tablet to facilitate aligning the tablet to the docking assembly in either a landscape or portrait mode.

A stimulator for stimulating the leg or other parts of the body e.g. the leg in a patient with drop foot is provided, the stimulator being controlled by e.g a foot switch but being reliable in use and therefore commanding acceptance by users. The foot switch has to work in adverse environmental conditions and is subject to repeated use so that its characteristics vary with time. The invention provides a functional electrical stimulator for attachment to the leg that has adaptive characteristics and comprises first and second electrodes for attachment to the leg to apply an electrical stimulus, a foot switch for sensing foot rise or foot strike, a circuit responsive to said foot switch for generating stimulation pulses; and means forming part of said circuit for responding to changes in the resistance characteristics of said switch means by adjusting a corresponding response threshold of said circuit.The invention also provides a two-channel stimulator that offers various possibilities for controlling the signals to be supplied to different muscle groups. For example, means may be provided defining a signal pathway between the first and second channels so that the supply of stimulation pulses in one of said first and second channels can be controlled by the state of switch means associated with the other of said first and second channels. In a further embodiment means defining a signal pathway between the first and second channels is arranged so that the supply of stimulation pulses in one of said first and second channels can be controlled by the state of activity of the other of said first and second channels. In a yet further embodiment the first channel has means arranged to cause the stimulation pulses to time-out after a predetermined period and the second channel having no or disabled timing means so that supply of stimulation pulses is continuous in a predetermined state of limb position responsive switch means associated with that channel. The two-channel stimulator can be used e.g., to treat bilateral dropped foot.

The invention provides methods and compositions for modulating the HGF / c-met signaling pathway, in particular by regulating c-met dimerization and / or binding of ligand to c-met using a c-met antagonist that disrupts c-met multimerization.

An electrosurgical apparatus having a feed structure comprising a radiofrequency (RF) channel for conveying RF electromagnetic (EM) radiation from an RF signal generator to a probe and a microwave channel for conveying microwave EM radiation from a microwave signal generator to the probe, wherein the RF channel and microwave channel comprise physically separate signal pathways, wherein the feed structure includes a combining circuit having an input connected to the signal pathway on the RF channel, another input connected to the signal pathway on the microwave channel, and an output connected to a common signal pathway for conveying the RE EM radiation and EM radiation separately or simultaneously to the probe, and wherein the microwave channel includes a waveguide isolator connected to isolate the signal pathway on the microwave channel from the RF EM radiation.

The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an RTK pathway. The invention also provides a method of using such status information to select patients responsive to pathway-specific drugs, and more particularly, to methods for measuring ErbB receptors and receptor complexes and using such information to select patients responsive to ErbB pathway-specific drugs. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more complexes formed in RTK activation. After binding, molecular tags are released and separated from the assay mixture for analysis.

A method is provided that includes receiving a request from a communication device to establish a communication session with a mobile station, the mobile station being operable to roam between a private and a public network. The mobile station is signaled via a cellular data network that a call is being initiated for the mobile station. Signaling information may be exchanged with a voice gateway such that one or more voice circuits are established. A signaling pathway may be established between an Internet protocol private branch exchange (IP PBX) and the mobile station via the cellular data network. The establishment of the signaling pathway is substantially concurrent with the establishment of one or more of the voice circuits. One or more features associated with a private network are delivered to the mobile station during the communication session as an end user moves between the public and private networks.

The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an RTK pathway. The invention also provides a method of using such status information to select patients responsive to pathway-specific drugs, and more particularly, to methods for measuring ErbB receptors and receptor complexes and using such information to select patients responsive to ErbB pathway-specific drugs. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more complexes formed in RTK activation. After binding, molecular tags are released and separated from the assay mixture for analysis.

The invention relates to a culture medium comprising an inhibitor of the BMP signaling pathway; and an inhibitor of the TGF / activin / nodal signaling pathway and to a method for obtaining a population of neural precursors using said culture medium.

The invention discloses an electronic device and a signal processing method thereof. The method includes that a first signal pathway module in the electronic device receives radiofrequency signals through a main set of antennas and transmits the received radiofrequency signals to at least one radio frequency module for processing, or transmits at least one radiofrequency signals sent by the at least one radio frequency module and sends the radiofrequency signals through the main set of antennas; a second signal pathway module receives radiofrequency signals through a diversity antenna used by the second signal pathway module and sends the radiofrequency signals to at least one radio frequency module for processing; a GPS signal pathway module receives GPS signals through a GPS antenna used by the GPS signal pathway module and sends the GPS signals to at least one radio frequency module for processing; and at least one radio frequency module receives GPS signals through the GPS signal pathway module and at least one signal pathway module in the second signal pathway module. The influence of multipath effect of GPS signals on reception performance of the GPS signals on reception performance of GPS signals during reception of GPS signals.

A system and method for integrating the call control signaling pathway with data network access components. A call control server agent is resident on a network device that provides a first interface from an access network to a packet-switched data network. The call control server agent receives data session initiation requests and passes the requests to the call control server agent. The call control server agent also performs proxy server functions and provides a source of information relating to data sessions directly to the access network.

A system and method for integrating the call control signaling pathway with data network access components. A call control server agent is resident on a network device that provides a first interface from an access network to a packet-switched data network. The call control server agent receives data session initiation requests and passes the requests to the call control server agent. The call control server agent also performs proxy server functions and provides a source of information relating to data sessions directly to the access network.

The invention provides a method of determining whether tumor cells or tissue is responsive to treatment with an ErbB pathway-specific drug. In accordance with the invention, measurements are made on such cells or tissues to determine values for total ErbB receptors of one or more types, ErbB receptor dimers of one or more types and their phosphorylation states, and / or one or more ErbB signaling pathway effector proteins and their phosphorylation states. These quantities, or a response index based on them, are positively or negatively correlated with cell or tissue responsiveness to treatment with an ErbB pathway-specific drug. In one aspect, such correlations are determined from a model of the mechanism of action of a ErbB pathway-specific drug on an ErbB pathway. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more complexes formed in ErbB pathway activation. After binding, molecular tags are released and separated from the assay mixture for analysis.

According to the present invention, the gene for IL-13, an anti-inflammatory cytokine, was shown to be a target of prostacyclin (PGI2)-activated Peroxisome proliferator-activated receptor (PPAR) δ. Furthermore, the PGI2-PPARδ signaling pathway was revealed to regulate the expression of IL-13 gene in human vascular endothelial cells, and controls inflammatory responses induced by proinflammatory cytokines through the production of IL-13 in an autocrine or paracrine manner. Thus, the present invention provides a method for treating or preventing inflammatory disorders, which comprises administering a therapeutically effective amount of PPARδ agonist into a subject. Furthermore, the present invention provides a method for treating or preventing inflammatory disorders, which comprises administering a prostacyclin synthase gene or a protein encoded by the gene into a subject.

The present invention relates to cyclic peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also relates to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.

Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the directed differentiation of stem cells and neuronal progenitor cells. The present disclosure relates to novel methods of in vitro differentiation of stem cells and neural progenitor cells to produce several type neuronal cells and their precursor cells, including cortical interneurons, hypothalamic neurons and pre-optic cholinergic neurons. The present disclose describes the derivation of these cells via inhibiting SMAD and Wnt signaling pathways and activating SHH signaling pathway. The present disclosure relates to the novel discovery that the timing and duration of SHH activation can be harnessed to direct controlled differentiation of neural progenitor cells into either cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons. The present disclosure also relates to compositions of cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons, and their precursors, that are highly enriched and can be used in variety of application. These cells can be used therapeutically to treat neurodegenerative and neuropsychiatric disorders, and can be used for disease modeling and drug screening.

Signaling paths and communication sessions, such as voice-over-IP sessions, can be established in substantially shorter and predictable time periods than previously thought possible over carrier-based, peer-to-peer networks (P2P). Instead of requiring a signaling pathway to traverse a large number of hops / nodes, novel architectures permit a signaling pathway to traverse a few designated host and anchor nodes that are part of a core of a P2P network. The novel architectures and related methods also make it possible to easily manage and maintain P2P networks.

The invention includes an apparatus and method for testing an electronic signal path. The apparatus includes a signal generator (102) configured to inject a test signal into the electronic signal path at an injection point when coupled to the signal path. The apparatus further includes a detector (104) coupled to the signal generator and configured to receive a combined signal at the injection point when coupled to the electronic signal path and determine an autocorrelation of the combined signal. The apparatus further includes an analyzer coupled to the detector and configured to determine a characteristic of the electronic signal path from the autocorrelation. The method includes injecting (902) a test signal into the electronic signal path an injection point, receiving (904) a combined signal from the electronic signal path at the injection point, determining (906) an autocorrelation of the combined signal, and estimating (908) a characteristic of the electronic signal path from the autocorrelation.

Methods of and apparatuses for matching the signal delay, clock timing, frequency response, gain, offset, and / or transfer function of signal pathways in electrical circuits such as, for example, time-interleaved and pipelined circuits using analog-valued floating-gate MOSFETs are disclosed. The methods and apparatuses disclosed are applicable to a variety of circuits, including but not limited to, sample-and-hold or track-and-hold circuits, quadrature mixers, analog-to-digital converters (ADCs), digital-to-analog converters (DACs), analog or digital filters, and amplifiers.

The present invention relates to methods for the induction and a cell to enter the Islet 1+ (Isl1+) lineage and methods for expansion of cells of islet 1+ lineage. One aspect of the present invention relates to methods to induce a cell to enter the islet 1+ lineage, and more particularly to a method to induce a cell to enter a the Isl1+ lineage to become an Isl1+ progenitor that is capable of differentiating along multiple different lineages such as a endothelial lineage, a smooth muscle lineage or a cardiac lineage. In particular, one embodiment present invention relates to methods to induce a cell to enter the Isl1+ lineage by inhibiting a wnt signalling pathway in the cell. Another aspect of the present invention relates to methods to expand a cell of the Isl1+ lineage, such as a Isl1+ progenitor by activating a wnt signalling pathway in the Isl1+ progenitor. Another aspect of the present invention relates to use of cells of the isl1+ lineage in subjects for therapeutic and preventative treatment of cardiovascular diseases.

The invention relates to a cell model obtained after targeted knockout of a rabbit BMP2 gene based on CRISPR / Cas9 and application thereof, belonging to the technical field of molecular biology and biomedicine. According to the invention corresponding oligos are synthesized for three targeting sites of the rabbit BMP2 gene on the design principles of CRISPR / Cas9 and are constructed on px458 vectors; and a CRISPR / Cas9 system is constructed directed at the three targeting sites in rabbit mesenchymal stem cells, and the CRISPR / Cas9 system can effectively knock out the rabbit BMP2 gene, is easy to operate and has high rabbit BMP2 gene knockout efficiency. The cell model disclosed in the invention can greatly promote research related to the functions and signaling pathways of the BMP2 gene.

The invention provides methods and compositions for modulating the HGF / c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.