147results about How to "Reliable response" patented technology

The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1 / PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

By using monitoring data, feedback data, and pooling of failure data from a plurality of electronic devices, real-time failure prediction and diagnoses of electronic systems operating in a network environment can be achieved. First, the diagnostic system requests data on the state of a machine and / or its components and collections thereof as part of the machine's normal operation. Secondly, real-time processing of the data either at the machine site or elsewhere in the distributed network allows for predicting or diagnosing system failures. Having determined and / or predicted a system failure, a communication to one or more remote observers in the network allows the remote observers to view the diagnostic information and / or required action to repair the failure. Furthermore, interrogation of either the particular electronic system, or a database containing data on similar electronic systems by the diagnostic server allows the diagnostic server to refine original diagnoses based on this population data to achieve a comprehensive failure predication / diagnosing system.

The present invention relates to a novel non-invasive perfusion / resistance status monitor system and methods of using the same, and more specifically, a vascular perfusion status monitor system receiving and processing signals from at least two pulse oximeter probes, where each of the at least two pulse oximeter probes are situated at advantageously different locations in a patient. Novel pulse oximeter probes are configured to be placed, respectively, across the lip or cheek, across the septum or nares of the nose, and on the tongue. These probes are fabricated to provide signals to estimate arterial oxygen saturation. Conventional oximeter probes also can be configured to function according to the novel methods of determining differences in peripheral blood flow and / or resistance described herein.

The disclosure provides a method for immunotherapy of a cancer patient, comprises administering to the patient an Ab that inhibits signaling from the PD-1 / PD-L1 signaling pathway, or a combination of such Ab and an anti-CTLA-4 Ab. This disclosure also provides a method for immunotherapy of a cancer patient comprising selecting a patient who is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the patient that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering an anti-PD-1 Ab to the selected subject. The disclosure additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

A method for providing an expanded name service for an industrial automation system, wherein name-address assignments between device names and communication network addresses are registered in a name service system to provide an expanded name service for an industrial automation system, where device names registered in the name service system have a hierarchical structure represented by a tree structure, where assignments between device names and plant identification codes are additionally registered in the name service system, where the plant identification codes are registered within the same tree structure as the device names, and where end nodes that are respectively assigned to the plant identification codes in the tree structure comprise either a reference to end nodes which are respectively assigned to the device names or intermediate nodes for plant identification codes comprise a reference to intermediate nodes that are respectively assigned to plant units.

The invention discloses a temperature sensing cooker capable of being used for various cooking ranges. The temperature sensing cooker comprises a pot body and a temperature sensing color change device in contact connection with the pot body, wherein the temperature sensing color change device comprises a plurality of temperature sensing color change bodies with non-overlapped color change temperature ranges, i.e., the plurality of color change bodies correspond to different cooking ranges. If open fire cooking ranges such as coal gas cooking ranges or natural gas cooking ranges are used for heating the temperature sensing cooker, when the pot bottom reaches the target temperature, the temperature sensing color change bodies of the pot body change the color; if electric cooking ranges such as induction cookers or electric ceramic cookers are used for heating, when the pot bottom reaches the target temperature, the temperature of the located pot body position of the temperature sensing color changing device is different front the temperature of the pot body; at the moment, the other corresponding temperature sensing color change body changes the color. The temperature sensing cooker has the advantages that when various different cooking ranges are used for heating, the temperature sensing cooker can correctly and timely reflect whether the pot bottom reaches the target temperature or not so that a user can master the cooking level; the generation of fume is reduced; the applicability to different cooking ranges is improved.

This disclosure provides a method for treating a subject afflicted with a lung cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an anti-cancer agent which is an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity; and (b) another anti-cancer agent. The other anti-cancer agent can be a platinum-based doublet chemotherapy, an EGFR-targeted tyrosine kinase inhibitor, bevacizumab, an anti-Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) antibody, or any other therapy used to treat lung cancer in the art or disclosed herein.

A moving contact assembly for a high-current interruption electric power switching apparatus has an inner carrier for the contact fingers that is rigidly held in a withstand position in an outer carrier by a spring biased cam follower pin engaging a cam profile on the inner carrier and configured to positively seat an inner carrier stop against an outer carrier stop on the outer carrier and to rapidly drive the inner carrier to a blow open position in response to a fault. The cam profile has an extended width divided between spaced apart cam profile sections to absorb the high closing and withstand forces. An abutment on the outer carrier resists bowing of the cam follower pin between the cam profile sections. Complementary convex and concave partial cylindrical surfaces on the inner carrier and a gas shield on the moving assembly carrier body maintain an arc gas seal during blow open.

This disclosure provides a method for treating a subject afflicted with a renal cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an anti-cancer agent which is an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity; and (b) another anti-cancer agent. The other anti-cancer agent may be an anti-angiogenic tyrosine kinase inhibitor or an anti-Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) antibody. The disclosure also provides a kit for treating a subject afflicted with a renal cancer, the kit comprising a dosage of an anti-PD-1 antibody, a dosage of another anti-cancer agent which is an anti-angiogenic tyrosine kinase inhibitor or an anti-CTLA-4 antibody, and instructions for using the anti-PD-1 antibody and the other anti-cancer agent in any of the disclosed methods for treating a renal cancer.

A method for responding to an existing or incipient surge condition of a turbocharger coupled to an engine of a motor vehicle is provided. The method comprises receiving a signal responsive to an operating condition of the turbocharger and adjusting one or more operating parameters of the motor vehicle when a power of the signal, integrated over a pre-selected range of non-zero frequencies, exceeds a pre-selected threshold. Other embodiments provide related systems for responding to an existing or incipient surge condition of a turbocharger.

The invention discloses a near space balloon system safety release method. The method comprises an unfolding stage, an inflation stage and a let-fly stage. By adopting the method, the windward area of a balloon is small in the inflation stage, an obvious wind-catching phenomenon is not caused, a set of hoists is adopted for multi-point constraint, the state of the balloon is controlled, thus the balloon is fixed safely and reliably, the wind resistance ability is high, thus the whole release process of a balloon system can be completely carried out in an external field, and a shelter place or a large-area ground is not needed; a descent control device is adopted, so that the liftoff speed of a nacelle and the relative speed between the nacelle and the balloon are lowered and the balloon system is lifted off safely; in the release process of the balloon, release can be performed only under the condition that rope belts are at a straightened state between the balloon and the nacelle, the balloon can be released without waiting for completely lifting off the ground, one person can complete initiation of all rope cutters in release operation, the operation is quick, and the response is timely and reliable; the release process is safe and smooth, and the method can be surely applied to releasing large-scale near space balloon systems with the load being higher than 100 kg.

The present invention relates to a method and an apparatus for simultaneously assessing the functional status of component parts of the nervous system by presenting sparse stimuli to one or more parts of the sensory nervous system. Sparse stimuli consist of temporal sequences of stimulus conditions presented against a baseline null stimulus condition, where the non-null stimulus condition, or conditions, are presented relatively infrequently. The low probability of encountering a stimulus differing from a baseline or null stimulus condition in sparse stimulus sequences insures that gain control mechanisms within the nervous system will increase the neural response magnitude and also bias the measured responses to those neurone populations having such gain controls. The consequently increased response amplitudes ensure more reliably recorded responses than are obtained with non-sparse stimuli.

The invention discloses a comprehensive security monitoring method and a comprehensive security monitoring system based on a sentry. The comprehensive security monitoring method includes the following implementation steps: 1) setting a sleep pulse critical value, a life weak pulse critical value and a human movement sign critical value; and 2) collecting pulse and human movement signs of sentry security personnel in real time. Security monitoring alarm is achieved according to three factors of the pulse, the human movement signs and manually triggered alarm, a sentry site video is collected through a camera during the triggered alarm, and alarm and the site video collected by the camera are sent to a monitoring center. The comprehensive security monitoring system comprise the monitoring center and at least one sentry unit, the sentry unit comprises a video monitoring unit, a sentry base station and at least one security personnel terminal, the video monitoring unit comprises the camera with a rotary platform, and the security personnel terminal comprises a pulse sensor, an attitude sensor, an alarm button, a terminal controller and a terminal wireless module. The comprehensive security monitoring method and the comprehensive security monitoring system based on the sentry have the advantages of being good in security, high in reliability, accurate in video monitoring and simpleand convenient to use.

Assessment of one of the sensory nervous systems of a human subject using patterns of null and non-null stimuli. Parts of the visual system for example, are presented with two simultaneous sequences of stimuli. Each sequence is varied over time between a null stimulus and one or more less frequent non-null stimuli. The variation of each sequence is also controlled so that neighbouring parts of the sensory system are less likely to receive simultaneous non-null stimuli. The stimuli are therefore sparse both in time and in some other aspect, typically a spatial dimension. One or more responses of the subject are measured and weight functions are determined for assessment of the sensory system.

A moving contact assembly for a high-current interruption electric power switching apparatus has an inner carrier for the contact fingers that is rigidly held in a withstand position in an outer carrier by a spring biased cam follower pin engaging a cam profile on the inner carrier and configured to positively seat an inner carrier stop against an outer carrier stop on the outer carrier and to rapidly drive the inner carrier to a blow open position in response to a fault. The cam profile has an extended width divided between spaced apart cam profile sections to absorb the high closing and withstand forces. An abutment on the outer carrier resists bowing of the cam follower pin between the cam profile sections. Complementary convex and concave partial cylindrical surfaces on the inner carrier and a gas shield on the moving assembly carrier body maintain an arc gas seal during blow open.

The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.

Methods, apparatus, and compositions calibrate a bio-photonic scanner detecting selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a processor, memory, and scanner. The scanner directs light nondestructively onto tissue in vivo, then receives back a radiant response through a system of mirrors and lenses back into the detector. Software for controlling the scanner and processing its output may be calibrated using a synthetic material to mimic the radiant response of tissue. Calibration may account for background fluorescence and elastic scattering, mimicking skin tissue materials having substantially no Raman scattering response of interest. Dopants may be added to the matrix of white scan material to mimic selected molecular structures in tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film and other materials.

The invention discloses an alarm and protection system for preventing water induction in an intake tube of an automobile engine, comprising a water induction detection device and an alarm and protection circuit (7). The water induction detection device comprises a floater chamber (3), a floater (4) which is arranged in the floater chamber (3) and vertically moves with the rising and lowering of water level, a fixed electrode which is arranged at the top part of the interior of the floater chamber (3), a floating electrode (21) which is arranged at the top part of the floater (4) and can be in electric contact with the fixed electrode, a water inlet (5) arranged at the lower part of the side wall of the floater chamber (3) and an air outlet which is arranged at the upper part of the side wall of the floater chamber (3). The alarm and protection circuit (7) comprises an alarm device which is connected with the fixed electrode and an engine control circuit (23) which is connected with the alarm device. The alarm and protection system of the invention has superior performance, quick response, reliability, simple structure and comparatively low cost.

A pharmaceutical combination comprising (a) CDK4 / 6 inhibitor (b) a B-Raf inhibitor, and optionally (c) a MEK 1 / 2 inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

The invention discloses a harvesting and vanning manipulator, comprising a matured vegetable input machine (1); the upper part of the matured vegetable input machine (1) is provided with a harvesting manipulator (2), and the side face of the harvesting manipulator (2) is provided with an empty dinner plate output machine (3) and a harvesting box conveyer (4). The harvesting and vanning manipulator can mainly realize the conveying of the dinner plate grown with matured vegetable to a limit position by means of the matured vegetable input machine, and keep motionless, harvest the vegetables in the dinner plate by the harvesting manipulator, and fill in the harvesting box conveyed by the harvesting box conveyer; the empty dinner plate is shifted to the dinner plate output machine through a disk shifting mechanism in the harvesting manipulator, thereby recycling empty dinner plate and realizing the full automatic of harvesting and vanning of matured vegetables. The harvesting and vanning manipulator is reasonable in layout of a driving belt, compact in structure, complete in function and strong in compatibility.

A method for responding to an existing or incipient surge condition of a turbocharger coupled to an engine of a motor vehicle is provided. The method comprises receiving a signal responsive to an operating condition of the turbocharger and adjusting one or more operating parameters of the motor vehicle when a power of the signal, integrated over a pre-selected range of non-zero frequencies, exceeds a pre-selected threshold. Other embodiments provide related systems for responding to an existing or incipient surge condition of a turbocharger.

The invention discloses an air renewing system in an automobile cab. The air renewing system comprises a signal detection module, a control module, an executing module, a solar energy supply module and an energy storage module, wherein the output end of the signal detection module is connected with the input end of the control module, the output end of the control module is connected with the input end of the executing module, the input end of the executing module is connected with the output end of the solar energy supply module, and the output end of the executing module is connected with the input end of the energy storage module. The solar energy is utilized for driving an automobile air conditioner to exchange air inside and outside an automobile under the condition that an automobile anti-theft system is started through monitoring the on-off signals of the anti-theft system, the temperature inside and outside the automobile, the storage battery state signal and the automobile air conditioner air inlet door state, so the air in the automobile is renewed and cooled.

A method, apparatus, and set of compositions are disclosed for calibrating a bio-photonic scanner. The scanner detects selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a computer, including processor and memory connecting to the scanner, including an illuminator to direct light nondestructively onto tissue in vivo, a detector to detect an intensity of a radiant response of the tissue to the light, and a probe to direct light onto the subject and receive a radiant response back into the detector. The apparatus is calibrated using a synthetic material to mimic the radiant response of live tissue, correcting for background fluorescence and elastic scattering. Dopants in a matrix of synthetic material mimic selected molecular structures of tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film powdered and mixed.

The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.

A safety system for a mobile anhydrous ammonia fertilizer application system is configured to be remotely actuated closed by the operator in the event of a leak in the system, and to automatically shutdown the system in the event of an actual or impending nurse tank breakaway.

Assessment of one of the sensory nervous systems of a human subject using patterns of null and non-null stimuli. Parts of the visual system for example, are presented with two simultaneous sequences of stimuli. Each sequence is varied over time between a null stimulus and one or more less frequent non-null stimuli. The variation of each sequence is also controlled so that neighboring parts of the sensory system are less likely to receive simultaneous non-null stimuli. The stimuli are therefore sparse both in time and in some other aspect, typically a spatial dimension. One or more responses of the subject are measured and weight functions are determined for assessment of the sensory system.

An oil supply structure for a continuously variable valve timing apparatus wherein a plurality of bimetal blocks change in shape based on oil temperature in an oil supply pipe, whereby, when an oil temperature rises, oil pressure supplied to a variable valve timing apparatus is automatically increased to provide the variable valve timing apparatus with a reliable response over an entire operating range.